中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [25]
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期刊论文 [92]
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Discovery and optimization of Menin-MLL inhibitors targeting acute myeloid leukemia
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2026, 卷号: 307, 页码: 15
作者:
Xiao, Qitao
;
Wang, Yuxian
;
Shen, Zheyuan
;
Mo, Jun
;
Li, Cong
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2026/04/01
MLL-R AML
Menin inhibitor
thieno[2
d ]pyrimidine
Machine learning
Skin-penetrating peptides derived from computational simulation improve transdermal absorption and facilitate topical treatment of melanoma
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2026, 卷号: 16, 期号: 2, 页码: 1140-1154
作者:
Du, Sanjiang
;
Wang, Hanlin
;
Geng, Feiyang
;
Zhang, Zongxu
;
Liu, Chenghao
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2026/04/01
Cell-penetrating peptides
Cutaneous administration
Computational simulation
Melanoma
Floxuridine
AlphaFold
Transdermal drug delivery
Penetratin
Temporal and spatial variations of redox conditions in the middle Triassic Chang 7 member of the Yanchang formation, Ordos Basin, North China
期刊论文
OAI收割
MARINE AND PETROLEUM GEOLOGY, 2025, 卷号: 182, 期号: 0, 页码: 12
作者:
Liu, Hanlin
;
Huang, Yuangeng
;
Zhao, Xiangdong
;
Wang, Wei
;
Qiu, Xincheng
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2025/12/02
Yanchang formation
Pyrite framboids
Element geochemistry
Biomarker
Organic matter
Rational engineering of degradation tail-driven CELMoD-antibody conjugates for precision malignancy therapy
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 12, 页码: 6510-6528
作者:
Guo, Yu
;
Song, Yi
;
Wang, Hanlin
;
Lu, Yang
;
Zhang, Jingyu
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2026/01/29
Degrader-antibody conjugate
Antibody-drug conjugate
Cereblon E3 ligase modulator
Immunomodulatory drug
Molecular glue
Targeted protein degradation
Multiple myeloma
Hematologic malignancy
Temporal and spatial variations of redox conditions in the middle Triassic Chang 7 member of the Yanchang formation, Ordos Basin, North China
期刊论文
OAI收割
MARINE AND PETROLEUM GEOLOGY, 2025, 卷号: 182, 页码: 12
作者:
Liu, Hanlin
;
Huang, Yuangeng
;
Zhao, Xiangdong
;
Wang, Wei
;
Qiu, Xincheng
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2025/12/19
Yanchang formation
Pyrite framboids
Element geochemistry
Biomarker
Organic matter
Assessment of flood risk in jinsha river basin based on land use value and PSR model
期刊论文
OAI收割
PHYSICS AND CHEMISTRY OF THE EARTH, 2025, 卷号: 141, 页码: 104139
作者:
Chen, Xiao
;
Zhai, Ran
;
Fang, Wen
;
Xu, Liwen
;
Liang, Lili
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2025/12/19
Flood
Risk assessment
PSR model
Basin flooding
Grey relation analysis
Design, synthesis, and evaluation of Menin-targeting compounds for the treatment of acute Myelocytic leukemia (AML)
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 296, 页码: 17
作者:
Mo, Jun
;
Wang, Yuxian
;
Pan, Youlu
;
Xiao, Qitao
;
Zhao, Jinyi
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2025/08/20
Menin
High binding affinity
Anti-proliferation activity
AML
Discovery of a Selective and Potent BCL6 PROTAC with Efficacious Antiproliferative Activity for the Treatment of Diffuse Large B-Cell Lymphoma
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 19, 页码: 20180-20206
作者:
Yu, Xiaoli
;
Liao, Xueyan
;
Zhang, Jingyu
;
Wang, Hanlin
;
Li, Xian
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2025/12/04
GLS1-RNA Polymerase II Axis Mediates Glutamine-Dependent Hepatoprotective Effects on Alcoholic Liver Disease in High-Protein Diets
期刊论文
OAI收割
ADVANCED SCIENCE, 2025, 页码: 16
作者:
Wu, Wenbiao
;
Jiang, Haowen
;
Liu, Yichang
;
Peng, Chang
;
Wang, Hanlin
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/12/04
alcoholic fatty liver disease
GLS1
hepatic lipogenesis
high-protein diets
RNA polymerase II
Depositional environments of the organic-rich shales from the Lower Cretaceous Dalazi Formation in the Yanji and Luozigou Basins of Northeast China
期刊论文
OAI收割
MARINE AND PETROLEUM GEOLOGY, 2025, 卷号: 179, 页码: 12
作者:
Zhao, Xiangdong
;
Wang, Wei
;
Liu, Hanlin
;
Hu, Yongliang
;
Zhao, Xianye
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/10/16
Ferruginous conditions
The Dalazi Formation
Iron speciation
Organic-rich shales
Cretaceous