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Comprehensive multi-omics analysis elucidates colchicine-induced toxicity mechanisms and unveils the therapeutic potential of MLN4924 and kinase inhibitors
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 13
作者:
Zhai, Lin-hui
;
Jia, Xing-long
;
Chen, Yu-lu
;
Liu, Mu-yin
;
Zhang, Jing-dan
  |  
收藏
  |  
浏览/下载:73/0
  |  
提交时间:2024/12/25
colchicine
MLN4924
multi-omics analysis
phosphoproteomics
ubiquitinomics
kinase inhibitor
Mass balance, metabolism, and pharmacokinetics of [
14
C]amdizalisib, a clinical-stage novel oral selective PI3Kδ inhibitor for the treatment of non-hodgkin's lymphoma, in healthy Chinese volunteers
期刊论文
OAI收割
FRONTIERS IN PHARMACOLOGY, 2024, 卷号: 15, 页码: 13
作者:
Zhao, Chun-Yang
;
Zhang, Li-Jun
;
Sun, Chan
;
Yu, Cheng-Yin
;
Wang, Jian
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/01/06
amdizalisib
PI3K delta kinase
metabolism
mass balance
metabolite identification
pharmacokinetics
safety
Circulating metabolites of
Borneolum syntheticum
(Bingpian) ameliorate atherosclerosis in ApoE
-/-
mice via inhibiting macrophage foam-cell formation
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 18
作者:
He, Rong-rong
;
Ma, Chuan-rui
;
He, Xin
;
Dong, Yan-xi
;
Li, Hui
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/11/26
Borneolum syntheticum
Bingpian
borneol
isoborneol
metabolism
atherosclerosis
Three-dimensional reconstruction of Late Miocene
Trapa
from eastern Zhejiang Province, China: Insights into its phytogeography and evolution
期刊论文
OAI收割
JOURNAL OF PALAEOGEOGRAPHY-ENGLISH, 2024, 卷号: 13, 期号: 4, 页码: 954-970
作者:
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2025/03/28
Trapa
Late miocene
Shengxian formation
Three-dimensional reconstruction
Phytogeographic history
Evolutionary history
19
F qNMR based pharmacokinetics, metabolism and mass balance studies of SARS-CoV-2-3CL protease inhibitor simnotrelvir (SIM0417) in humans
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 11
作者:
Wang, Ze-yu
;
Ren, Yong-mei
;
Hu, Shu-wei
;
Zhang, Nai-xia
;
Dong, Meng-xiao
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/11/05
COVID-19
simnotrelvir
F-19 qNMR
pharmacokinetics
metabolism
mass balance.
Heterozygous variants in USP25 cause genetic generalized epilepsy
期刊论文
OAI收割
BRAIN, 2024, 页码: 16
作者:
Fan, Cui-Xia
;
Liu, Xiao-Rong
;
Mei, Dao-Qi
;
Li, Bing-Mei
;
Li, Wen-Bin
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/10/09
genetic generalized epilepsy
USP25
gain of function
loss of function
Transcriptomic decoding of regional cortical vulnerability to major depressive disorder
期刊论文
OAI收割
COMMUNICATIONS BIOLOGY, 2024, 卷号: 7, 期号: 1, 页码: 12
作者:
Zhu, Jiajia
;
Chen, Xiao
;
Lu, Bin
;
Li, Xue-Ying
;
Wang, Zi-Han
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/09/10
Luteolin-7-diglucuronide, a novel PTP1B inhibitor, ameliorates hepatic stellate cell activation and liver fibrosis in mice
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 12
作者:
Tang, Bi-xi
;
Zhang, Yong
;
Sun, Dan-dan
;
Liu, Qin-yi
;
Li, Cong
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2024/09/26
liver fibrosis
phytochemical
luteolin 7-diglucuronide
HSC activation
PTP1B
Sepsis Biomarkers: Advancements and Clinical Applications-A Narrative Review
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 卷号: 25, 期号: 16, 页码: 30
作者:
He, Rong-Rong
;
Yue, Guo-Li
;
Dong, Mei-Ling
;
Wang, Jia-Qi
;
Cheng, Chen
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/10/21
sepsis
biomarkers
diagnosis
prognosis
clinical applications
Regulation of Glandular Size and Phytoalexin Biosynthesis by a Negative Feedback Loop in Cotton
期刊论文
OAI收割
ADVANCED SCIENCE, 2024, 页码: 11
作者:
Wu, Wen-Kai
;
Nie, Gui-Bin
;
Lin, Jia-Ling
;
Huang, Jia-Fa
;
Guo, Xiao-Xiang
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/07/12
cotton
jasmonate
pigment gland
VQ domain