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浏览/检索结果: 共340条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序作者升序作者降序题名升序题名降序发表日期升序发表日期降序 Conformational restriction enables discovering a series of chroman derivatives as potent and selective NaV1.8 inhibitors with improved pharmacokinetic properties 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 293, 页码: 24 作者:  Li, Na;  Wang, Linlin;  Hu, Xinyuan;  Xu, Haiyan;  Yang, Bowen   |  收藏  |  浏览/下载：1/0  |  提交时间：2025/08/20 Voltage-gated sodium channel 1.8  Conformational restriction  Pharmacokinetic  Structure-activity relationship  Analgesic   EP240801a/XRF 240801B: An X-Ray Flash Detected by the Einstein Probe and the Implications of Its Multiband Afterglow 期刊论文  OAI收割 ASTROPHYSICAL JOURNAL LETTERS, 2025, 卷号: 988, 期号: 1 作者:  Jiang, Shuai-Qing;  Xu, Dong;  Hoof, Agnes P. C. van;  Lei, Wei-Hua;  Liu, Yuan   |  收藏  |  浏览/下载：20/0  |  提交时间：2025/07/28 Contrastive learning-based drug screening model for GluN1/GluN3A inhibitors 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2025, 页码: 13 作者:  Li, Kun;  Zeng, Yue;  Xiong, Yi-da;  Wu, Hao-chen;  Fang, Sui   |  收藏  |  浏览/下载：3/0  |  提交时间：2025/08/20 drug-target affinity prediction  virtual screening  contrastive learning  graph neural network  N-methyl-D-aspartate (NMDA) receptors  GluN3A subunit.   Structure-Based Discovery of a Series of Novel MAT2a Inhibitors 期刊论文  OAI收割 ACS MEDICINAL CHEMISTRY LETTERS, 2025, 页码: 5 作者:  Zhou, Yushan;  Wang, Li;  Ren, Ruyue;  Zhang, Junjie   |  收藏  |  浏览/下载：10/0  |  提交时间：2025/05/27 MAT2a  MTAP  Synthetic lethality  Allosteric inhibitor  Structure-activity relationship   Design of Selective BRD4 Inhibitors for the Treatment of Autosomal Dominant Polycystic Kidney Disease 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2025, 页码: 18 作者:  Yang, Yueyue;  Liu, Hongli;  Yuan, Haoxing;  Lyu, Kaikai;  Zhong, Haiyang   |  收藏  |  浏览/下载：29/0  |  提交时间：2025/04/01 Structure-Based Rational Design and Evaluation of BET-Aurora Kinase Dual-Inhibitors for Treatment of Cancers 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 21 作者:  Lyu, Kaikai;  Ren, Ying;  Mou, Jie;  Yang, Yunfang;  Pan, Yaoyao   |  收藏  |  浏览/下载：21/0  |  提交时间：2025/02/28 Design and development of a series of 4-(piperazin-1-yl)pyrimidines as irreversible menin inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 280, 页码: 20 作者:  Luo, Menglan;  Ye, Yunfei;  Tang, Lu;  Kan, Weijuan;  Chen, Lin   |  收藏  |  浏览/下载：33/0  |  提交时间：2024/11/26 Menin  Covalent inhibitor  Antitumor  Degradation   FAPM: functional annotation of proteins using multimodal models beyond structural modeling 期刊论文  OAI收割 BIOINFORMATICS, 2024, 卷号: 40, 期号: 12, 页码: 12 作者:  Xiang, Wenkai;  Xiong, Zhaoping;  Chen, Huan;  Xiong, Jiacheng;  Zhang, Wei   |  收藏  |  浏览/下载：119/0  |  提交时间：2025/01/14 Optimization and Biological Evaluation of Novel 1H-Pyrrolo[2,3-c]pyridin Derivatives as Potent and Reversible Lysine Specific Demethylase 1 Inhibitors for the Treatment of Acute Myelogenous Leukemia 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 24, 页码: 22080-22103 作者:  Jiang, Hong;  Li, Cong;  Li, Na;  Sheng, Li;  Wang, Jingkai   |  收藏  |  浏览/下载：34/0  |  提交时间：2025/01/14 Structural mechanism of human HCN1 hyperpolarization-activated channel inhibition by ivabradine 期刊论文  OAI收割 JOURNAL OF BIOLOGICAL CHEMISTRY, 2024, 卷号: 300, 期号: 11, 页码: 9 作者:  Che, Tong;  Zhang, Wei;  Cheng, Xinyu;  Lv, Sijia;  Zhang, Minqing   |  收藏  |  浏览/下载：44/0  |  提交时间：2024/11/26