机构

• 上海药物研究所 [17]
• 广州生物医药与健康研... [6]
• 武汉病毒研究所 [1]

采集方式

• OAI收割 [23]
• iSwitch采集 [1]

内容类型

• 期刊论文 [24]

发表日期

• 2024 [5]
• 2023 [4]
• 2022 [5]
• 2017 [2]
• 2015 [3]
• 2013 [4]
• 更多

学科主题

• Pharmacolo... [4]
• Biochemist... [2]
• Chemistry [2]

筛选

浏览/检索结果: 共24条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 An updated patent review of SOS1 inhibitors (2022-present) 期刊论文  OAI收割 EXPERT OPINION ON THERAPEUTIC PATENTS, 2024, 页码: 15 作者:  Zhou, Guizhen;  Zhou, Chuan;  Ma, Xinyi;  Xu, Jiahang;  Zhou, Zehui   |  收藏  |  浏览/下载：3/0  |  提交时间：2024/12/11 SOS1  KRAS  cancer  inhibitor  drug discovery   Design, Synthesis, and Biological Evaluation of 2,4-Diaminopyrimidine Derivatives as Potent CDK7 Inhibitors 期刊论文  OAI收割 ACS MEDICINAL CHEMISTRY LETTERS, 2024, 页码: 8 作者:  Zhang, Hualin;  Tu, Yutong;  Tao, Zhaofan;  Gao, Lixin;  Huang, Shengjie   |  收藏  |  浏览/下载：9/0  |  提交时间：2024/08/22 CDK7 inhibitor  2,4-diaminopyrimidine  selectivity  anticancer   Design, synthesis, and bioevaluation of SOS1 PROTACs derived from pyrido [2,3- d ]pyrimidin-7-one-based SOS1 inhibitor 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 107, 页码: 9 作者:  Wang, Kun;  Zhou, Zehui;  Ma, Xinyi;  Xu, Jiahang;  Xu, Wangyang   |  收藏  |  浏览/下载：21/0  |  提交时间：2024/07/12 SOS1  KRAS mutation  PROTAC  Anti-cancer activity   Design, Synthesis, and Bioevaluation of Transcriptional Enhanced Assocciated Domain (TEAD) PROTAC Degraders 期刊论文  OAI收割 ACS MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 15, 期号: 5, 页码: 631-639 作者:  Li, Huajie;  Ge, Zhiming;  Lin, Kexin;  He, Wei;  Chu, Qinyu   |  收藏  |  浏览/下载：39/0  |  提交时间：2024/06/27 Hippo pathway  TEAD  PROTAC  Selectivity   Design, Synthesis, and Biological Evaluation of Potent and Selective PROTAC Degraders of Oncogenic KRASG12D 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 2, 页码: 1147-1167 作者:  Zhou, Chuan;  Fan, Zisheng;  Gu, Yuejiao;  Ge, Zhiming;  Tao, Zhaofan   |  收藏  |  浏览/下载：25/0  |  提交时间：2024/02/27 Discovery of ARD-1676 as a Highly Potent and Orally Efficacious AR PROTAC Degrader with a Broad Activity against AR Mutants for the Treatment of AR plus Human Prostate Cancer 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 18, 页码: 13280-13303 作者:  Xiang, Weiguo;  Zhao, Lijie;  Han, Xin;  Xu, Tianfeng;  Kregel, Steven   |  收藏  |  浏览/下载：23/0  |  提交时间：2023/12/08 Stimuli-activatable PROTACs for precise protein degradation and cancer therapy 期刊论文  OAI收割 SCIENCE BULLETIN, 2023, 卷号: 68, 期号: 10, 页码: 1069-1085 作者:  Gao, Jing;  Yang, Lei;  Lei, Shumin;  Zhou, Feng;  Nie, Huijun   |  收藏  |  浏览/下载：21/0  |  提交时间：2023/10/17 PROTAC  Stimuli-activatable prodrug  Precise protein degradation  Nanomedicine  Combinatory therapy   Discovery of a Potent, Cooperative, and Selective SOS1 PROTAC ZZ151 with In Vivo Antitumor Efficacy in KRAS-Mutant Cancers 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 6, 页码: 4197-4214 作者:  Zhou, Zehui;  Zhou, Guizhen;  Zhou, Chuan;  Fan, Zisheng;  Cui, Rongrong   |  收藏  |  浏览/下载：24/0  |  提交时间：2024/03/27 Design, Synthesis, and Bioevaluation of Pyrido[2,3-d]pyrimidin-7-ones as Potent SOS1 Inhibitors 期刊论文  OAI收割 ACS MEDICINAL CHEMISTRY LETTERS, 2023, 页码: 183-190 作者:  Liu, Meiying;  Zhou, Guizhen;  Su, Wenhong;  Gu, Yuejiao;  Gao, Mingshan   |  收藏  |  浏览/下载：23/0  |  提交时间：2024/03/27 KRAS mutation  SOS1-KRAS interaction  SOS1 inhibitor  combination therapy   Engineered bioorthogonal POLY-PROTAC nanoparticles for tumour-specific protein degradation and precise cancer therapy 期刊论文  OAI收割 NATURE COMMUNICATIONS, 2022, 卷号: 13, 期号: 1, 页码: 14 作者:  Gao, Jing;  Hou, Bo;  Zhu, Qiwen;  Yang, Lei;  Jiang, Xingyu   |  收藏  |  浏览/下载：60/0  |  提交时间：2022/08/30