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浏览/检索结果: 共91条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers 期刊论文  OAI收割 CANCER LETTERS, 2024, 卷号: 582, 页码: 15 作者:  Lu, Xuxiu;  Yu, Rilei;  Li, Zhen;  Yang, Mengke;  Dai, Jiajia   |  收藏  |  浏览/下载：13/0  |  提交时间：2024/04/07 Acquired resistance  Cancer  NSCLC  JC-010a  SHP2   EPHA2 feedback activation limits the response to PDEδ inhibition in KRAS-dependent cancer cells (vol 41, pg 270, 2020) 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2024, 页码: 2 作者:  Chen, Yue-hong;  Lv, Hao;  Shen, Ning;  Wang, Xiao-min;  Tang, Shuai   |  收藏  |  浏览/下载：19/0  |  提交时间：2024/03/06 Design, Synthesis, and Biological Evaluation of Potent and Selective PROTAC Degraders of Oncogenic KRASG12D 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 2, 页码: 1147-1167 作者:  Zhou, Chuan;  Fan, Zisheng;  Gu, Yuejiao;  Ge, Zhiming;  Tao, Zhaofan   |  收藏  |  浏览/下载：9/0  |  提交时间：2024/02/27 Targeting ST8SIA6-AS1 counteracts KRASG12C inhibitor resistance through abolishing the reciprocal activation of PLK1/c-Myc signaling 期刊论文  OAI收割 EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2023, 卷号: 12, 期号: 1, 页码: 22 作者:  Wang, Yafang;  Yao, Mingyue;  Li, Cheng;  Yang, Kexin;  Qin, Xiaolong   |  收藏  |  浏览/下载：7/0  |  提交时间：2024/01/26 KRAS(G12C)  c-Myc  PLK1  LncRNA  ST8SIA6-AS1  Drug resistance   From bench to bedside: current development and emerging trend of KRAS-targeted therapy 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 页码: 18 作者:  Chen, Yi;  Liu, Qiu-pei;  Xie, Hua;  Ding, Jian   |  收藏  |  浏览/下载：27/0  |  提交时间：2024/01/16 KRAS mutation  KRAS(G12C) inhibitor  Pan-KRAS inhibitor  SHP2 allosteric inhibitor  SOS1 inhibitor  combination therapy   Tetrandrine synergizes with MAPK inhibitors in treating KRAS-mutant pancreatic ductal adenocarcinoma via collaboratively modulating the TRAIL-death receptor axis 期刊论文  OAI收割 PHARMACOLOGICAL RESEARCH, 2023, 卷号: 197, 页码: 12 作者:  Tang, Shuai;  Duan, Yichen;  Yuan, Tao;  Hu, Yutinh;  Yuan, Liang   |  收藏  |  浏览/下载：8/0  |  提交时间：2023/12/11 KRAS  Pancreatic ductal adenocarcinoma  MAPK pathway  Tetrandrine  TRAIL  Death receptors   Genomic and transcriptomic profiling indicates the prognosis significance of mutational signature for TMB-high subtype in Chinese patients with gastric cancer 期刊论文  OAI收割 JOURNAL OF ADVANCED RESEARCH, 2023, 卷号: 51, 页码: 121-134 作者:  Cheng, Yanan;  Bu, Dechao;  Zhang, Qiaoling;  Sun, Rebecca;  Lyle, Stephen   |  收藏  |  浏览/下载：6/0  |  提交时间：2023/12/04 Gastric cancer  Comprehensive genomic profiling  TMB  Mutational signature  Tumor metabolism   Dominant neoantigen verification in hepatocellular carcinoma by a single-plasmid system coexpressing patient HLA and antigen 期刊论文  OAI收割 JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2023, 卷号: 11, 期号: 4, 页码: 16 作者:  Chen, Pu;  Chen, Dongbo;  Bu, Dechao;  Gao, Jie;  Qin, Wanying   |  收藏  |  浏览/下载：6/0  |  提交时间：2023/12/04 Liver Neoplasms  Antigens  Neoplasm  Immunotherapy  Immunoassay  Immunogenicity  Vaccine   Discovery of a Potent, Cooperative, and Selective SOS1 PROTAC ZZ151 with In Vivo Antitumor Efficacy in KRAS-Mutant Cancers 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 6, 页码: 4197-4214 作者:  Zhou, Zehui;  Zhou, Guizhen;  Zhou, Chuan;  Fan, Zisheng;  Cui, Rongrong   |  收藏  |  浏览/下载：1/0  |  提交时间：2024/03/27 Covalent inhibitor targets KRasG12C: A new paradigm for drugging the undruggable and challenges ahead 期刊论文  OAI收割 GENES & DISEASES, 2023, 卷号: 10, 期号: 2, 页码: 403-414 作者:  Li, Hui-yu;  Qi, Wei-liang;  Wang, Yu-xiang;  Meng, Ling-hua   |  收藏  |  浏览/下载：117/0  |  提交时间：2023/10/17 Biomarkers  Covalent KRasG12Cinhibitors  Drug resistance  Human cancers  KRASG12Cmutation