机构

• 上海药物研究所 [8]
• 上海生物化学与细胞生... [8]
• 合肥物质科学研究院 [7]
• 昆明动物研究所 [3]
• 化学研究所 [2]
• 自动化研究所 [2]
• 更多

采集方式

• OAI收割 [33]
• iSwitch采集 [1]

内容类型

• 期刊论文 [34]

发表日期

• 2024 [2]
• 2023 [4]
• 2022 [3]
• 2021 [6]
• 2019 [2]
• 2018 [2]
• 更多

学科主题

• Oncology [3]
• Respirator... [2]
• Science & ... [2]
• Biotechnol... [1]
• Cell Biolo... [1]
• Chemistry,... [1]
• 更多

筛选

浏览/检索结果: 共34条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers 期刊论文  OAI收割 CANCER LETTERS, 2024, 卷号: 582, 页码: 15 作者:  Lu, Xuxiu;  Yu, Rilei;  Li, Zhen;  Yang, Mengke;  Dai, Jiajia   |  收藏  |  浏览/下载：13/0  |  提交时间：2024/04/07 Acquired resistance  Cancer  NSCLC  JC-010a  SHP2   Design, Synthesis, and Biological Evaluation of Potent and Selective PROTAC Degraders of Oncogenic KRASG12D 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 2, 页码: 1147-1167 作者:  Zhou, Chuan;  Fan, Zisheng;  Gu, Yuejiao;  Ge, Zhiming;  Tao, Zhaofan   |  收藏  |  浏览/下载：10/0  |  提交时间：2024/02/27 From bench to bedside: current development and emerging trend of KRAS-targeted therapy 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 页码: 18 作者:  Chen, Yi;  Liu, Qiu-pei;  Xie, Hua;  Ding, Jian   |  收藏  |  浏览/下载：28/0  |  提交时间：2024/01/16 KRAS mutation  KRAS(G12C) inhibitor  Pan-KRAS inhibitor  SHP2 allosteric inhibitor  SOS1 inhibitor  combination therapy   Genomic and transcriptomic profiling indicates the prognosis significance of mutational signature for TMB-high subtype in Chinese patients with gastric cancer 期刊论文  OAI收割 JOURNAL OF ADVANCED RESEARCH, 2023, 卷号: 51, 页码: 121-134 作者:  Cheng, Yanan;  Bu, Dechao;  Zhang, Qiaoling;  Sun, Rebecca;  Lyle, Stephen   |  收藏  |  浏览/下载：6/0  |  提交时间：2023/12/04 Gastric cancer  Comprehensive genomic profiling  TMB  Mutational signature  Tumor metabolism   Covalent inhibitor targets KRasG12C: A new paradigm for drugging the undruggable and challenges ahead 期刊论文  OAI收割 GENES & DISEASES, 2023, 卷号: 10, 期号: 2, 页码: 403-414 作者:  Li, Hui-yu;  Qi, Wei-liang;  Wang, Yu-xiang;  Meng, Ling-hua   |  收藏  |  浏览/下载：117/0  |  提交时间：2023/10/17 Biomarkers  Covalent KRasG12Cinhibitors  Drug resistance  Human cancers  KRASG12Cmutation   Design, Synthesis, and Bioevaluation of Pyrido[2,3-d]pyrimidin-7-ones as Potent SOS1 Inhibitors 期刊论文  OAI收割 ACS MEDICINAL CHEMISTRY LETTERS, 2023, 页码: 183-190 作者:  Liu, Meiying;  Zhou, Guizhen;  Su, Wenhong;  Gu, Yuejiao;  Gao, Mingshan   |  收藏  |  浏览/下载：7/0  |  提交时间：2024/03/27 KRAS mutation  SOS1-KRAS interaction  SOS1 inhibitor  combination therapy   Safety and Efficacy of D-1553 in Patients with KRAS G12C Mutated Non-Small Cell Lung Cancer: A Phase 1 Trial 期刊论文  OAI收割 JOURNAL OF THORACIC ONCOLOGY, 2022, 卷号: 17 作者:  Lu, S.;  Jian, H.;  Zhang, Y.;  Song, Z.;  Zhao, Y.   |  收藏  |  浏览/下载：22/0  |  提交时间：2022/12/23 Non-small cell lung cancer  KRAS G12C mutation  Small molecular inhibitor   Multimodule characterization of immune subgroups in intrahepatic cholangiocarcinoma reveals distinct therapeutic vulnerabilities 期刊论文  OAI收割 JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 卷号: 10, 期号: 7, 页码: 14 作者:  Lin, Jian;  Dai, Yuting;  Sang, Chen;  Song, Guohe;  Xiang, Bin   |  收藏  |  浏览/下载：35/0  |  提交时间：2022/08/30 tumor microenvironment  cytotoxicity  immunologic  drug therapy  combination   p Proteogenomic characterization identifies clinically relevant subgroups of intrahepatic cholangiocarcinoma 期刊论文  OAI收割 CANCER CELL, 2022, 卷号: 40, 期号: 1, 页码: 70-+ 作者:  Dong, Liangqing;  Lu, Dayun;  Chen, Ran;  Lin, Youpei;  Zhu, Hongwen   |  收藏  |  浏览/下载：33/0  |  提交时间：2022/06/15 Genomic alterations in biliary tract cancer predict prognosis and immunotherapy outcomes 期刊论文  OAI收割 JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 卷号: 9 作者:  Chen, Xiaofeng;  Wang, Deqiang;  Liu, Jing;  Qiu, Jingrong;  Zhou, Jun   |  收藏  |  浏览/下载：78/0  |  提交时间：2022/01/10 immunotherapy  tumor microenvironment  biomarkers  tumor  genetic markers