机构

• 上海药物研究所 [17]
• 金属研究所 [2]
• 青海盐湖研究所 [2]
• 广州生物医药与健康研... [2]
• 物理研究所 [1]
• 中国科学院大学 [1]
• 更多

采集方式

• OAI收割 [27]
• iSwitch采集 [2]

内容类型

• 期刊论文 [29]

发表日期

• 2025 [2]
• 2024 [3]
• 2022 [4]
• 2021 [2]
• 2020 [6]
• 2019 [3]
• 更多

学科主题

• Chemistry [2]

筛选

浏览/检索结果: 共29条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Development of novel epoxyketone macrocyclic peptidyl proteasome inhibitors through OPA-mediated one-step cyclization of unprotected peptides 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2025, 卷号: 156, 页码: 16 作者:  Zeng, Gongruixue;  Xu, Gaoya;  Gao, Lixin;  Zheng, Xiaoli;  Chi, Xinglong   |  收藏  |  浏览/下载：9/0  |  提交时间：2025/04/01 Proteasome inhibitors  Macrocycle  Stability  Anti-cancer activities   Auto-RapTAC: A Versatile and Sustainable Platform for the Automated Rapid Synthesis and Evaluation of PROTAC 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2025, 页码: 15 作者:  Chen, Jiexuan;  Wu, Mingfei;  Mo, Jun;  Hong, Ju;  Wang, Wei   |  收藏  |  浏览/下载：13/0  |  提交时间：2025/04/01 Exploration of novel 20S proteasome activators featuring anthraquinone structures and their application in hypoxic cardiomyocyte protection 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2024, 卷号: 115, 页码: 10 作者:  Yu, Qian;  Gao, Lixin;  Xu, Linhao;  Han, Yubing;  Cao, Yu   |  收藏  |  浏览/下载：11/0  |  提交时间：2024/12/11 Single-cell sequencing reveals the heterogeneity of pancreatic neuroendocrine tumors under genomic instability and histological grading 期刊论文  OAI收割 ISCIENCE, 2024, 卷号: 27, 期号: 9, 页码: 18 作者:  Ye, Zeng;  Zhou, Yan;  Hu, Yuheng;  Li, Qiang;  Xu, Zijin   |  收藏  |  浏览/下载：11/0  |  提交时间：2024/11/05 tumor cells  CNV neutral tumor cells  neuroendocrine cells  profile   Discovery of a Highly Potent and Selective BRD9 PROTAC Degrader Based on E3 Binder Investigation for the Treatment of Hematological Tumors 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 28 作者:  Duan, Haiting;  Zhang, Jingyu;  Gui, Renzhao;  Lu, Yang;  Pang, Ao   |  收藏  |  浏览/下载：7/0  |  提交时间：2024/08/20 Structure-based rational design enables efficient discovery of a new selective and potent AKT PROTAC degrader 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 238, 页码: 15 作者:  Zhu, Cheng-Liang;  Luo, Xiaomin;  Tian, Tian;  Rao, Zijian;  Wang, Hanlin   |  收藏  |  浏览/下载：40/0  |  提交时间：2022/08/16 AKT  Protein kinase B  PROTAC  Chemical degrader  Rational design   Structural Feature Analyzation Strategies toward Discovery of Orally Bioavailable PROTACs of Bruton's Tyrosine Kinase for the Treatment of Lymphoma 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 13, 页码: 9096–9125 作者:  Zhang, Jingyu;  Che, Jinxin;  Luo, Xiaomin;  Wu, Mingfei;  Kan, Weijuan   |  收藏  |  浏览/下载：47/0  |  提交时间：2024/03/21 Design, synthesis and biological evaluation of sulfonamides inhibitors of XPO1 displaying activity against multiple myeloma cells 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 235 作者:  Qu, Bingxue;  Xu, Yongjin;  Lu, Yang;  Zhuang, Weihao;  Jin, Xinxin   |  收藏  |  浏览/下载：43/0  |  提交时间：2022/12/23 XPO1  Multiple myeloma  MM.1S  N-phenylsulfonamide  Oral administration   Discovery of seneciobipyrrolidine derivatives for the amelioration of glucose homeostasis disorders through 4E-BP1/Akt/AMPK signaling activation 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 228, 页码: 25 作者:  Che, Jinxin;  Ma, Canliang;  Lu, Jialiang;  Chen, Binhui;  Shi, Qiuqiu   |  收藏  |  浏览/下载：47/0  |  提交时间：2022/06/15 Seneciobipyrrolidine  Phenotypic screening  Glucose homeostasis  Proteomic analysis  L6 myotubes  4E-BP1   Advancing COVID-19 diagnosis with privacy-preserving collaboration in artificial intelligence 期刊论文  OAI收割 NATURE MACHINE INTELLIGENCE, 2021, 卷号: 3, 期号: 12, 页码: 1081-1089 作者:  Bai, Xiangd;  Wang, Hanchen;  Ma, Liya;  Xu, Yongchao;  Gan, Jiefeng   |  收藏  |  浏览/下载：78/0  |  提交时间：2022/01/18