机构

• 上海药物研究所 [142]
• 上海应用物理研究所 [3]
• 新疆理化技术研究所 [2]
• 广州生物医药与健康研... [2]
• 昆明植物研究所 [1]

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• OAI收割 [150]

内容类型

• 期刊论文 [148]
• 会议论文 [2]

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• 2024 [10]
• 2023 [22]
• 2022 [10]
• 2021 [10]
• 2020 [14]
• 2019 [6]
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学科主题

• Cell Biolo... [2]
• Chemistry [1]
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浏览/检索结果: 共150条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Potency Prediction of Covalent Inhibitors against SARS-CoV-2 3CL-like Protease and Multiple Mutants by Multiscale Simulations 期刊论文  OAI收割 JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2024, 卷号: 64, 期号: 24, 页码: 9501-9516 作者:  Xiong, Muya;  Nie, Tianqing;  Li, Zhewen;  Hu, Meiyi;  Su, Haixia   |  收藏  |  浏览/下载：4/0  |  提交时间：2025/01/06 Covalent DNA-Encoded Library Workflow Drives Discovery of SARS-CoV-2 Nonstructural Protein Inhibitors 期刊论文  OAI收割 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2024, 页码: 14 作者:     |  收藏  |  浏览/下载：6/0  |  提交时间：2024/12/25 Discovery of Novel Nonpeptidic and Noncovalent Small Molecule 3CLpro Inhibitors as anti-SARS-CoV-2 Drug Candidate 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 15, 页码: 12760-12783 作者:  Jiang, Zhidong;  Feng, Bo;  Chen, Lu;  Nie, Tianqing;  Chen, Shizhao   |  收藏  |  浏览/下载：15/0  |  提交时间：2024/09/26 PPIA dictates NRF2 stability to promote lung cancer progression 期刊论文  OAI收割 NATURE COMMUNICATIONS, 2024, 卷号: 15, 期号: 1, 页码: 20 作者:  Lu, Weiqiang;  Cui, Jiayan;  Wang, Wanyan;  Hu, Qian;  Xue, Yun   |  收藏  |  浏览/下载：23/0  |  提交时间：2024/07/12 Identification of Dihydrobenzofuran Neolignans as Novel PDE4 Inhibitors and Evaluation of Antiatopic Dermatitis Efficacy in DNCB-Induced Mice Model 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 6, 页码: 4855-4869 作者:  Gu, Chenming;  Liu, Jiayuan;  Qian, Fei;  Yu, Wenchao;  Huang, Doudou   |  收藏  |  浏览/下载：8/0  |  提交时间：2024/05/07 Chemical Space Profiling of SARS-CoV-2 PLpro Using DNA-Encoded Focused Libraries 期刊论文  OAI收割 ACS MEDICINAL CHEMISTRY LETTERS, 2024, 页码: 10 作者:  Wang, Xudong;  Zhu, Ying;  Zhao, Qingyi;  Lu, Weiwei;  Xu, Yechun   |  收藏  |  浏览/下载：10/0  |  提交时间：2024/05/07 DNA-Encoded Focused Libraries (DEFLs)  SARS-CoV-2  Papain-like Protease  Library Design  ProteinInhibitors   Design, synthesis and biological evaluation of betulinic acid derivatives as potential inhibitors of 3CL-protease of SARS-CoV-2 期刊论文  OAI收割 STEROIDS, 2024, 卷号: 202, 页码: 8 作者:  Liu, Yaowen;  Nie, Tianqing;  Hou, Jinjun;  Long, Huali;  Zhang, Zijia   |  收藏  |  浏览/下载：27/0  |  提交时间：2024/03/13 3CLpro  SARS-CoV-2  Betulinic acid  Natural product  Inhibitory activity   Oral Simnotrelvir for Adult Patients with Mild-to-Moderate Covid-19 期刊论文  OAI收割 NEW ENGLAND JOURNAL OF MEDICINE, 2024, 卷号: 390, 期号: 3, 页码: 230-241 作者:  Cao, Bin;  Wang, Yeming;  Lu, Hongzhou;  Huang, Chaolin;  Yang, Yumei   |  收藏  |  浏览/下载：21/0  |  提交时间：2024/05/07 Structure-based design of potent FABP4 inhibitors with high selectivity against FABP3 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 264, 页码: 10 作者:  Chen, Guofeng;  Xie, Hang;  Liu, Jiayuan;  Shao, Qiang;  Li, Minjun   |  收藏  |  浏览/下载：19/0  |  提交时间：2024/01/26 Methyl substitution  Selectivity  FABP4 inhibitor  Anti-inflammation  Metabolic stability   Structure-based development of potent and selective type-II kinase inhibitors of RIPK1 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 1, 页码: 319-334 作者:  Qin, Ying;  Li, Dekang;  Qi, Chunting;  Xiang, Huaijiang;  Meng, Huyan   |  收藏  |  浏览/下载：22/0  |  提交时间：2024/03/06 RIPK1  Necroptosis  Type-II kinase inhibitors  Rational design  Lead optimization  Structure-activity relationship  Anti-inflammation  Preclinical drug discovery