机构

• 上海药物研究所 [11]
• 沈阳自动化研究所 [1]

采集方式

• OAI收割 [12]

内容类型

• 期刊论文 [12]

发表日期

• 2023 [1]
• 2022 [4]
• 2021 [3]
• 2020 [4]

学科主题

筛选

浏览/检索结果: 共12条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Sequence-based drug design as a concept in computational drug design 期刊论文  OAI收割 NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 21 作者:  Chen, Lifan;  Fan, Zisheng;  Chang, Jie;  Yang, Ruirui;  Hou, Hui   |  收藏  |  浏览/下载：43/0  |  提交时间：2023/10/17 Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia 期刊论文  OAI收割 CELL RESEARCH, 2022, 页码: 19 作者:  Hu, Cheng-Long;  Chen, Bing-Yi;  Li, Zijuan;  Yang, Tianbiao;  Xu, Chun-Hui   |  收藏  |  浏览/下载：49/0  |  提交时间：2022/12/13 Prediction of serious eye damage or eye irritation potential of compounds via consensus labelling models and active learning models based on uncertainty strategies 期刊论文  OAI收割 Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2022, 卷号: 169, 页码: 113420 作者:  Di, Peiwen;  Zheng, Mingyue;  Yang, Tianbiao;  Chen, Geng;  Ren, Jianan   |  收藏  |  浏览/下载：7/0  |  提交时间：2024/03/15 Active learning  Consensus labelling  Eye irritation  Serious eye damage  Structural alerts   Discovery of Pyrazolo[3,4-d]pyridazinone Derivatives as Selective DDR1 Inhibitors via Deep Learning Based Design, Synthesis, and Biological Evaluation 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 1, 页码: 103-119 作者:  Tan, Xiaoqin;  Li, Chunpu;  Yang, Ruirui;  Zhao, Sen;  Li, Fei   |  收藏  |  浏览/下载：46/0  |  提交时间：2022/06/15 Optogenetically engineered cell-based graphene transistor for pharmacodynamic evaluation of anticancer drugs 期刊论文  OAI收割 Sensors and Actuators B: Chemical, 2022, 卷号: 358, 页码: 1-11 作者:  Yang J(杨佳);  Li GX(李恭新);  Zu LP(祖立鹏);  Wang WX(王文学);  Ge ZX(葛治星)   |  收藏  |  浏览/下载：78/0  |  提交时间：2022/03/07 Cell-based biosensor  Optogenetics  Photosensitive proteins  Cancer cells  Graphene transistor  Pharmacodynamic evaluation   Drug target inference by mining transcriptional data using a novel graph convolutional network framework 期刊论文  OAI收割 PROTEIN & CELL, 2021, 页码: 21 作者:  Zhong, Feisheng;  Wu, Xiaolong;  Yang, Ruirui;  Li, Xutong;  Wang, Dingyan   |  收藏  |  浏览/下载：32/0  |  提交时间：2021/12/01 drug target inference  transcriptomics  deep learning  experimental verification   Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 3, 页码: 781-794 作者:  Wu, Xiaowei;  Dai, Mengdi;  Cui, Rongrong;  Wang, Yulan;  Li, Chunpu   |  收藏  |  浏览/下载：51/0  |  提交时间：2021/05/24 Tyrosine kinase  Covalent FGFR inhibitors  Virtual screening  Pyrazolo[3,4-d] pyridazinone  Structure-activity relationships  Antitumor efficacy   DrugSpaceX: a large screenable and synthetically tractable database extending drug space 期刊论文  OAI收割 NUCLEIC ACIDS RESEARCH, 2021, 卷号: 49, 期号: D1, 页码: D1170-D1178 作者:  Yang, Tianbiao;  Li, Zhaojun;  Chen, Yingjia;  Feng, Dan;  Wang, Guangchao   |  收藏  |  浏览/下载：56/0  |  提交时间：2021/05/24 Deep Learning Enhancing Kinome-Wide Polypharmacology Profiling: Model Construction and Experiment Validation 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 16, 页码: 8723-8737 作者:  Li, Xutong;  Li, Zhaojun;  Wu, Xiaolong;  Xiong, Zhaoping;  Yang, Tianbiao   |  收藏  |  浏览/下载：42/0  |  提交时间：2020/12/21 Deep Learning Enhancing Kinome-Wide Polypharmacology Profiling: Model Construction and Experiment Validation 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 16, 页码: 8723-8737 作者:  Li, Xutong;  Li, Zhaojun;  Wu, Xiaolong;  Xiong, Zhaoping;  Yang, Tianbiao   |  收藏  |  浏览/下载：28/0  |  提交时间：2020/12/21