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浏览/检索结果: 共176条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序作者升序作者降序题名升序题名降序发表日期升序发表日期降序 Discovery of pyrrolo[2,3-d]pyrimidine derivatives as novel FLT3/ IRAK4 inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 296, 页码: 23 作者:  Yuan, Haibin;  Gao, Yue;  Wang, Peipei;  Dong, Xiaowu;  Li, Jia   |  收藏  |  浏览/下载：1/0  |  提交时间：2025/08/20 AML  FLT3/IRAK4 inhibitor  Pyrrolo [2,3-d] pyrimidine  Acquired resistance  Adaptive resistance   Design, synthesis, and evaluation of Menin-targeting compounds for the treatment of acute Myelocytic leukemia (AML) 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 296, 页码: 17 作者:  Mo, Jun;  Wang, Yuxian;  Pan, Youlu;  Xiao, Qitao;  Zhao, Jinyi   |  收藏  |  浏览/下载：4/0  |  提交时间：2025/08/20 Menin  High binding affinity  Anti-proliferation activity  AML   Palladium-Catalyzed Enantioselective Arylative Dearomatization of Naphthols and Phenols for Constructing Quinazoline-Containing Spirocycles 期刊论文  OAI收割 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025, 页码: 9 作者:  Zhang, Chiyue;  Xu, Gaoya;  Zhao, Wenlu;  Li, Xutong;  Zheng, Mingyue   |  收藏  |  浏览/下载：17/0  |  提交时间：2025/07/25 Antiproliferative activity  Catalytic asymmetric dearomatization  Palladium  Quinazoline-containing spirocycles  Three-dimensionality   Cross-Linking Profiling of Molecular Glue Degrader-Induced E3 Ligase Interactome to Expand Target Space 期刊论文  OAI收割 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025, 页码: 13 作者:  Xu, Yali;  Zhao, Wensi;  Nie, Hui-Jun;  Wang, Jiamin;  Fu, Jingjing   |  收藏  |  浏览/下载：20/0  |  提交时间：2025/05/27 Chemoproteomics  Genetic code expansion  Molecular glue degrader  Photo-crosslinking  Targeted protein degradation   Development of novel epoxyketone macrocyclic peptidyl proteasome inhibitors through OPA-mediated one-step cyclization of unprotected peptides 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2025, 卷号: 156, 页码: 16 作者:  Zeng, Gongruixue;  Xu, Gaoya;  Gao, Lixin;  Zheng, Xiaoli;  Chi, Xinglong   |  收藏  |  浏览/下载：33/0  |  提交时间：2025/04/01 Proteasome inhibitors  Macrocycle  Stability  Anti-cancer activities   Discovery of a potential hematologic malignancies therapy: Selective and potent HDAC7 PROTAC degrader targeting non-enzymatic function 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 3, 页码: 1659-1679 作者:  Jin, Yuheng;  Qi, Xuxin;  Yu, Xiaoli;  Cheng, Xirui;  Chen, Boya   |  收藏  |  浏览/下载：19/0  |  提交时间：2025/06/23 HDAC7  PROTAC  Selectivity  Hematologic malignancies  Non-enzymatic function   Cavity oscillation drives pattern formation in early mammalian embryos 期刊论文  OAI收割 CELL REPORTS, 2025, 卷号: 44, 期号: 3, 页码: 115342 作者:  Guo, Zheng;  Yao, Jie;  Zheng X(郑旭);  Cao, Jialing;  Lv, Xinxin   |  收藏  |  浏览/下载：18/0  |  提交时间：2025/07/21 cavity oscillation  EPI/PrE segregation  pattern formation  early mammalian embryos  blastocyst   Harnessing the Magic Methyl Effect: Discovery of CLPP-2068 as a Novel HsClpP Activator for the Treatment of Diffuse Large B-Cell Lymphoma 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 4, 页码: 4287-4307 作者:  Sun, Mingyang;  Chen, Beijing;  Teng, Dan;  Zhao, Hongshen;  Liao, Yilie   |  收藏  |  浏览/下载：34/0  |  提交时间：2025/04/01 Auto-RapTAC: A Versatile and Sustainable Platform for the Automated Rapid Synthesis and Evaluation of PROTAC 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2025, 页码: 15 作者:  Chen, Jiexuan;  Wu, Mingfei;  Mo, Jun;  Hong, Ju;  Wang, Wei   |  收藏  |  浏览/下载：31/0  |  提交时间：2025/04/01 Design and development of a series of 4-(piperazin-1-yl)pyrimidines as irreversible menin inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 280, 页码: 20 作者:  Luo, Menglan;  Ye, Yunfei;  Tang, Lu;  Kan, Weijuan;  Chen, Lin   |  收藏  |  浏览/下载：33/0  |  提交时间：2024/11/26 Menin  Covalent inhibitor  Antitumor  Degradation