中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [97]
合肥物质科学研究院 [38]
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期刊论文 [516]
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Design, synthesis, and evaluation of Menin-targeting compounds for the treatment of acute Myelocytic leukemia (AML)
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 296, 页码: 17
作者:
Mo, Jun
;
Wang, Yuxian
;
Pan, Youlu
;
Xiao, Qitao
;
Zhao, Jinyi
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/08/20
Menin
High binding affinity
Anti-proliferation activity
AML
Discovery of novel imidazo[2,1-b][1,3,4]thiadiazole analogs as fluorescent SHP2 inhibitors
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 163, 页码: 10
作者:
Zhang, Chun
;
Yan, Xue
;
Gao, Li-Xin
;
Cao, Zi-Tong
;
Cao, Qing
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2025/08/20
Imidazo[2,1-b][1,3,4]thiadiazole
Inhibitory activities
Fluorescence imaging
Zebrafish
SHP2
Nonlinear Imaging Detection of Organ Fibrosis in Minute Samples for Early Stage Utilizing Dual-Channel Two-Photon and Second-Harmonic Excitation
期刊论文
OAI收割
BIOSENSORS-BASEL, 2025, 卷号: 15, 期号: 6, 页码: 16
作者:
Yu, Bo-Song
;
Cheng, Qing-Di
;
Liu, Yi-Zhou
;
Zhang, Rui
;
Li, Da-Wei
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/08/20
nonlinear imaging
two-photon excitation
second harmonic generation
fibrosis
Monitoring AGNs with Hβ Asymmetry. V. Long-term Variation and Evolution of the Broad Hβ Emission-line Profiles
期刊论文
OAI收割
ASTROPHYSICAL JOURNAL SUPPLEMENT SERIES, 2025, 卷号: 278, 期号: 2
作者:
Fang, Feng-Na
;
Du, Pu
;
Brotherton, Michael S.
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2025/06/10
Synthesis and Evaluation of Optical Properties, SHP2 Inhibitory Activity, and Cellular Imaging for Novel 2-Quinolone Derivatives
期刊论文
OAI收割
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2025, 页码: 10
作者:
Zhang, Chun
;
Yang, Yuting
;
Gao, Li-Xin
;
Gan, Suya
;
Li, Jia
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2025/05/27
Fluorescent inhibitors
SHP2
2-quinolone derivatives
optical properties
drug tracing
medical diagnosis
Synthesis, fluorescence properties of novel thiazolo[3,2-b][1,2,4]triazol derivatives as potent SHP2 inhibitors and its uses in sensing for Fe3+and cell imaging
期刊论文
OAI收割
JOURNAL OF MOLECULAR STRUCTURE, 2025, 卷号: 1324, 页码: 12
作者:
Yan, Xue
;
Zhang, Chun
;
Gao, Li-Xin
;
Cao, Zi-Tong
;
Gan, Su-Ya
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2025/01/14
Thiazolo[3,2-b][1,2,4]triazole
Salicylic acid
Fe3+ion
Fluorescence property
SHP2
Fertilization regulates maize nutrient use efficiency through soil rhizosphere biological network and root transcriptome
期刊论文
OAI收割
APPLIED SOIL ECOLOGY, 2025, 卷号: 207, 页码: 13
作者:
Luo, Bowen
;
Hu, Huiling
;
Zheng, Hao
;
An, Ningxin
;
Guo, Jia
  |  
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2025/03/24
Fertilization strategies
Maize production
Soil biota
Trophic interactions
Root traits
LSTM-based proxy model combined with wellbore-reservoir coupling simulations for predicting multi-dimensional state parameters in depleted gas reservoirs
期刊论文
OAI收割
COMPUTERS & GEOSCIENCES, 2025, 卷号: 196, 页码: 15
作者:
Zhang, Jinyong
;
Hong, Yi
;
Wang, Lizhong
;
Li, Xiaochun
;
Lei, Hongwu
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2025/06/27
CO 2 sequestration
Wellbore-reservoir coupling
Pressure buildup
Depleted gas reservoirs
LSTM
Prediction
Exploratory research on the effective chemical basis of tanreqing injection for treating acute lung injury: In vivo, in vitro and in silico
期刊论文
OAI收割
JOURNAL OF ETHNOPHARMACOLOGY, 2025, 卷号: 337, 页码: 11
作者:
Tang, Bixi
;
Xie, Like
;
Wang, Yangyang
;
Shi, Yulong
;
Kan, Weijuan
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2024/11/26
Lung first-pass effect
Tanreqing injection
Pharmacokinetics
Sepsis-associated acute lung injury
Acute respiratory distress syndrome
6
H
-Indolo-[2,3-
b
]-quinoxaline derivatives as promising bifunctional SHP1 inhibitors
期刊论文
OAI收割
ORGANIC & BIOMOLECULAR CHEMISTRY, 2024, 页码: 12
作者:
Zhang, Chun
;
Dong, Yi-Xin
;
Gao, Li-Xin
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2025/02/28