中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [13]
金属研究所 [8]
武汉物理与数学研究所 [2]
采集方式
OAI收割 [23]
内容类型
期刊论文 [22]
会议论文 [1]
发表日期
2024 [3]
2023 [4]
2022 [3]
2019 [3]
2018 [2]
2017 [3]
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学科主题
Materials ... [1]
Metallurgy... [1]
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共23条,第1-10条
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A novel isoquinoline alkaloid HJ-69 isolated from Zanthoxylum bungeanum attenuates inflammatory pain by inhibiting voltage-gated sodium and potassium channels
期刊论文
OAI收割
JOURNAL OF ETHNOPHARMACOLOGY, 2024, 卷号: 330, 页码: 12
作者:
Wang, Long
;
Hao, Haishuang
;
Meng, Xianhua
;
Zhang, Wenbo
;
Zhang, Yin
  |  
收藏
  |  
浏览/下载:113/0
  |  
提交时间:2024/11/05
HJ-69
Zanthoxylum bungeanum
Isoquinoline alkaloid
Nav
Kv
Inflammatory pain
Discovery of Novel Pyrimidine-Based Derivatives as Nav1.2 Inhibitors with Efficacy in Mouse Models of Epilepsy
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 15, 页码: 12912-12931
作者:
He, Guoxue
;
Zheng, Yueming
;
Chang, Shunzhen
;
Wang, Long
;
Yang, Xiaohao
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2024/09/26
Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses
期刊论文
OAI收割
NATURE CHEMICAL BIOLOGY, 2024, 页码: 29
作者:
Zhou, Xiaoyu
;
Zhao, Cheng
;
Xu, Haiyan
;
Xu, Yixiang
;
Zhan, Li
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2024/03/25
Ligand activation mechanisms of human KCNQ2 channel
期刊论文
OAI收割
Nature communications, 2023, 卷号: 14, 期号: 1, 页码: 6632
作者:
Ma, Demin
;
Zheng, Yueming
;
Li, Xiaoxiao
;
Zhou, Xiaoyu
;
Yang, Zhenni
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2024/03/26
Discovery of selective NaV1.8 inhibitors based on 5-chloro-2-(4,4-difluor- oazepan-1-yl)-6-methyl nicotinamide scaffold for the treatment of pain
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 254, 页码: 12
作者:
Qin, Hui
;
Wei, Aihuan
;
Wang, Yunqi
;
Wang, Linlin
;
Xu, Haiyan
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2023/10/17
Pain
Non-addictive analgesics
Na V 1
8-selective inhibitors
Bicyclic aromatic groups
Design, Synthesis and Bioactivity of [3.3.3]Propellane-Based Voltage-Gated Calcium Channel alpha 2 delta Subunit Ligands
期刊论文
OAI收割
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2023, 卷号: 43, 期号: 6, 页码: 2226-2238
作者:
He Jinyan
;
Tian Fuyun
;
Wu Qingqing
;
Zheng Yueming
;
Chen Yuting
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2023/10/17
propellane
voltage-gated calcium channel
alpha 2 delta subunit
synthesis
bioactivity
structure-activity relationship
Naphthylisoquinoline alkaloids,a new structural template inhibitor of Navl.7 sodium channel
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 卷号: 44, 期号: 9, 页码: 1768
作者:
Wang Qiaoqiao
;
Wang Long
;
Zhang Wenbo
;
Tang Chunping
;
Chen Xueqin
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2023/12/08
Navl.7 channel
naphthylisoquinolines
Ancistrocladus tectorius
dorsal root ganglion neurons
formalin-induced mouse inflammatory pain model
analgesics
Study on structure-activity relationship (SAR) of simplified mirogabalin derivatives as voltage-gated calcium channel alpha 2 delta ligands for the treatment of chronic neuropathic pain
期刊论文
OAI收割
MEDICINAL CHEMISTRY RESEARCH, 2022, 页码: 26
作者:
Zhang, Yuanwen
;
Zheng, Yueming
;
Wu, Qingqing
;
Tian, Fuyun
;
Ma, Chuanjun
  |  
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2023/04/10
Voltage-gated calcium channel
alpha 2 delta subunit
gamma-aminobutyric acid
Mirogabalin
Neuropathic pain
Structure-activity relationship
Identification of a Subtype-Selective Allosteric Inhibitor of GluN1/GluN3 NMDA Receptors
期刊论文
OAI收割
FRONTIERS IN PHARMACOLOGY, 2022, 卷号: 13, 页码: 13
作者:
Zeng, Yue
;
Zheng, Yueming
;
Zhang, Tongtong
;
Ye, Fei
;
Zhan, Li
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2022/08/16
N-methyl-D-aspartate (NMDA) receptors
GluN3 subunits
WZB117
allosteric modulator
ion channels
drug discovery
The Atomic Oxygen Erosion Resistance Effect and Mechanism of the Perhydropolysilazane-Derived SiOx Coating Used on Polymeric Materials in Space Environment
期刊论文
OAI收割
POLYMERS, 2022, 卷号: 14, 期号: 2, 页码: 14
作者:
Qi, Hong
;
Shi, Qingshan
;
Qian, Yuhai
;
Li, Yueming
;
Xu, Jingjun
  |  
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2022/07/01
PHPS
silica coating
atomic oxygen
erosion-corrosion
resistance mechanism