中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [28]
昆明植物研究所 [23]
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期刊论文 [303]
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Design, synthesis, and evaluation of Menin-targeting compounds for the treatment of acute Myelocytic leukemia (AML)
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 296, 页码: 17
作者:
Mo, Jun
;
Wang, Yuxian
;
Pan, Youlu
;
Xiao, Qitao
;
Zhao, Jinyi
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收藏
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浏览/下载:9/0
  |  
提交时间:2025/08/20
Menin
High binding affinity
Anti-proliferation activity
AML
EP240801a/XRF 240801B: An X-Ray Flash Detected by the Einstein Probe and the Implications of Its Multiband Afterglow
期刊论文
OAI收割
ASTROPHYSICAL JOURNAL LETTERS, 2025, 卷号: 988, 期号: 1
作者:
Jiang, Shuai-Qing
;
Xu, Dong
;
Hoof, Agnes P. C. van
;
Lei, Wei-Hua
;
Liu, Yuan
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2025/07/28
Noise Reduction Method for Radio Astronomy Single Station Observation Based on Wavelet Transform and Mathematical Morphology
期刊论文
OAI收割
RESEARCH IN ASTRONOMY AND ASTROPHYSICS, 2025, 卷号: 25, 期号: 7
作者:
Qin, Ming-Wei
;
Tang, Rui
;
Zhou, Ying-Hui
;
Lan, Chang-Jun
;
Fu, Wen-Hao
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2025/07/03
methods: data analysis
techniques: image processing
techniques: spectroscopic
Sun: radio radiation
methods: numerical
A Hybrid-Targeting Nanoparticle for Penetrable Delivery of Temozolomide to Enhance Glioblastoma Therapy
期刊论文
OAI收割
NANO LETTERS, 2025, 卷号: 25, 期号: 19, 页码: 7989-7997
作者:
Wang, Guanru
;
Guo, Hao
;
Wei, Mengxin
;
Wang, Ying
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2025/06/23
glioblastoma
chemotherapy
drug delivery
tumor-specific drugaccumulation
tumor-suppressiveeffects
Ordovician-Devonian granites and Li-Be-bearing pegmatites in the Altyn Tagh Orogen, NW China
期刊论文
OAI收割
GEOLOGICAL SOCIETY OF AMERICA BULLETIN, 2025, 页码: 21
作者:
Jing, Yan
;
Zhang, Chuan-lin
;
Wang, Chen
;
Ge, Wen-chun
;
Song, Zhi-hao
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2025/07/11
Cross-Linking Profiling of Molecular Glue Degrader-Induced E3 Ligase Interactome to Expand Target Space
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025, 页码: 13
作者:
Xu, Yali
;
Zhao, Wensi
;
Nie, Hui-Jun
;
Wang, Jiamin
;
Fu, Jingjing
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收藏
  |  
浏览/下载:28/0
  |  
提交时间:2025/05/27
Chemoproteomics
Genetic code expansion
Molecular glue degrader
Photo-crosslinking
Targeted protein degradation
Terrestrial ecosystem response to Early Cretaceous global environmental change: A calibrated, high-resolution Aptian record from Northeast China
期刊论文
OAI收割
EARTH AND PLANETARY SCIENCE LETTERS, 2025, 卷号: 653, 页码: 13
作者:
Sun, Ming-Dao
;
Lin, Qin
;
Ramezani, Jahandar
;
Liu, Jiang-Si
;
Lu, Zheng-An
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收藏
  |  
浏览/下载:52/0
  |  
提交时间:2025/04/03
Early Cretaceous
Aptian
CA-ID-TIMS geochronology
Astrochronology
Carbon isotope stratigraphy
The JCMT BISTRO Survey: The Magnetic Fields of the IC 348 Star-forming Region
期刊论文
OAI收割
The Astrophysical Journal, 2024, 卷号: 977, 期号: 1, 页码: 32
作者:
Choi,Youngwoo
;
Kwon,Woojin
;
Pattle,Kate
;
Arzoumanian,Doris
;
Bourke,Tyler L.
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2025/01/02
Comprehensive multi-omics analysis elucidates colchicine-induced toxicity mechanisms and unveils the therapeutic potential of MLN4924 and kinase inhibitors
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 13
作者:
Zhai, Lin-hui
;
Jia, Xing-long
;
Chen, Yu-lu
;
Liu, Mu-yin
;
Zhang, Jing-dan
  |  
收藏
  |  
浏览/下载:98/0
  |  
提交时间:2024/12/25
colchicine
MLN4924
multi-omics analysis
phosphoproteomics
ubiquitinomics
kinase inhibitor
Tofacitinib prevents depressive-like behaviors through decreased hippocampal microgliosis and increased BDNF levels in both LPS-induced and CSDS-induced mice
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 13
作者:
Gao, Ya-nan
;
Pan, Kai-jun
;
Zhang, Yong-mei
;
Qi, Ying-bei
;
Chen, Wen-gang
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2024/11/05
tofacitinib
depression
JAK-STAT pathway
microgliosis
synaptic defects