中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [30]
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Adaptive Optimal Output Regulation of Interconnected Singularly Perturbed Systems With Application to Power Systems
期刊论文
OAI收割
IEEE/CAA Journal of Automatica Sinica, 2024, 卷号: 11, 期号: 3, 页码: 595-607
作者:
Jianguo Zhao
;
Chunyu Yang
;
Weinan Gao
;
Linna Zhou
;
Xiaomin Liu
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/02/19
Adaptive optimal control
decentralized control
output regulation
reinforcement learning (RL)
singularly perturbed systems (SPSs)
KinomeMETA: meta-learning enhanced kinome-wide polypharmacology profiling
期刊论文
OAI收割
BRIEFINGS IN BIOINFORMATICS, 2024, 卷号: 25, 期号: 1, 页码: 15
作者:
Ren, Qun
;
Qu, Ning
;
Sun, Jingjing
;
Zhou, Jingyi
;
Liu, Jin
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/05/07
kinome profiling
kinase inhibitors
polypharmacology
deep learning
meta-learning
Discovery of PVD-06 as a Subtype-Selective and Efficient PTPN2 Degrader
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 22, 页码: 15269-15287
作者:
Hu, Linghao
;
Li, Huiyun
;
Qin, Junlin
;
Yang, Dan
;
Liu, Jieming
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2024/02/27
Tetrandrine synergizes with MAPK inhibitors in treating KRAS-mutant pancreatic ductal adenocarcinoma via collaboratively modulating the TRAIL-death receptor axis
期刊论文
OAI收割
PHARMACOLOGICAL RESEARCH, 2023, 卷号: 197, 页码: 12
作者:
Tang, Shuai
;
Duan, Yichen
;
Yuan, Tao
;
Hu, Yutinh
;
Yuan, Liang
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2023/12/11
KRAS
Pancreatic ductal adenocarcinoma
MAPK pathway
Tetrandrine
TRAIL
Death receptors
Sequence-based drug design as a concept in computational drug design
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 21
作者:
Chen, Lifan
;
Fan, Zisheng
;
Chang, Jie
;
Yang, Ruirui
;
Hou, Hui
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2023/10/17
A RIPK3-independent role of MLKL in suppressing parthanatos promotes immune evasion in hepatocellular carcinoma
期刊论文
OAI收割
CELL DISCOVERY, 2023, 卷号: 9, 期号: 1, 页码: 15
作者:
Jiang, Xifei
;
Deng, Wenjia
;
Tao, Siyao
;
Tang, Zheng
;
Chen, Yuehong
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2023/04/10
Development and validation of an autophagy-related long non-coding RNA prognostic signature for cervical squamous cell carcinoma and endocervical adenocarcinoma
期刊论文
OAI收割
FRONTIERS IN ONCOLOGY, 2022, 卷号: 12
作者:
Zhou, Shuguang
;
Zhang, Weiyu
;
Cao, Wujun
;
Jin, Qinqin
;
Jiang, Xiya
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2022/12/23
cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC)
long noncoding RNA (lncRNA)
autophagy-related genes (ARGs)
autophagy-related lncRNAs (ARLs)
prognostic signature
immune infiltration
PD-L1/TLR7 dual-targeting nanobody-drug conjugate mediates potent tumor regression via elevating tumor immunogenicity in a host-expressed PD-L1 bias-dependent way
期刊论文
OAI收割
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 卷号: 10, 期号: 10, 页码: 15
作者:
Yu, Xiaolu
;
Long, Yiru
;
Chen, Binfan
;
Tong, Yongliang
;
Shan, Mengwen
  |  
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2022/12/13
PD-L1
TLR7
nanobody-drug-conjugate
cancer immunotherapy
Expert consensus on the diagnosis and treatment of NTRK gene fusion solid tumors in China
期刊论文
OAI收割
THORACIC CANCER, 2022
作者:
Xu, Chunwei
;
Si, Lu
;
Wang, Wenxian
;
Li, Ziming
;
Song, Zhengbo
  |  
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2022/12/22
fusion
precision medicine
solid tumor
targeted therapy
tyrosine receptor kinase
Triazine-Based Covalent DNA-Encoded Libraries for Discovery of Covalent Inhibitors of Target Proteins
期刊论文
OAI收割
ACS MEDICINAL CHEMISTRY LETTERS, 2022, 页码: 8
作者:
Li, Linjie
;
Su, Mingbo
;
Lu, Weiwei
;
Song, Hongzhi
;
Liu, Jiaxiang
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2022/09/30
DNA encoded library
covalent library
library design
covalent inhibitors