中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [7]
计算技术研究所 [3]
上海微系统与信息技术... [2]
武汉岩土力学研究所 [2]
生物物理研究所 [1]
上海营养与健康研究所 [1]
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OAI收割 [17]
内容类型
期刊论文 [17]
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2024 [3]
2023 [1]
2022 [2]
2021 [2]
2020 [2]
2016 [1]
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学科主题
Engineerin... [1]
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Discovery of a Covalent Inhibitor That Overcame Resistance to Venetoclax in AML Cells Overexpressing BFL-1
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 36
作者:
Lou, Jianfeng
;
Zhou, Qianqian
;
Lyu, Xilin
;
Cen, Xinyi
;
Liu, Chen
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/08/22
Synthesis and biological evaluation of 4-imidazolidinone-containing compounds as potent inhibitors of the MDM2/p53 interaction
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 270, 页码: 16
作者:
Lin, Zhitong
;
Liu, Chen
;
Yan, Ziqin
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2024/06/27
MDM2
p53
p21
Imidazolidinone
Apoptosis
Fine-Grained Open-Set Deepfake Detection via Unsupervised Domain Adaptation
期刊论文
OAI收割
IEEE TRANSACTIONS ON INFORMATION FORENSICS AND SECURITY, 2024, 卷号: 19, 页码: 7536-7547
作者:
Zhou, Xinye
;
Han, Hu
;
Shan, Shiguang
;
Chen, Xilin
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/12/06
Deepfakes
Adaptation models
Feature extraction
Data models
Face recognition
Training
Faces
Deepfake detection
domain adaptation
unsupervised learning
fine-grained classification
Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 24, 页码: 16991-17025
作者:
Cheng, Jing
;
Yan, Ziqin
;
Jiang, Kailong
;
Liu, Chen
;
Xu, Dehua
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2024/02/19
Rock Salt Under Cyclic Loading with High-Stress Intervals
期刊论文
OAI收割
ROCK MECHANICS AND ROCK ENGINEERING, 2022, 卷号: 55, 期号: 7, 页码: 4031
作者:
Zhao, Kai
;
Ma, Hongling
;
Zhou, Jun
;
Yin, Hongwu
;
Li, Peng
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2023/08/02
Rock salt
Cyclic loading
High-stress interval
Life predication
Compressed air energy storage
Discovery of a selective and covalent small-molecule inhibitor of BFL-1 protein that induces robust apoptosis in cancer cells
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 236, 页码: 114327
作者:
Feng, Xuexin
;
Yan, Ziqin
;
Zhou, Feilong
;
Lou, Jianfeng
;
Lyu, Xilin
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2024/03/21
BFL-1
Apoptosis
Covalent inhibitor
Cytochrome c
BCL-2
Protein-Protein interaction
Synthesis and bioactivity studies of covalent inhibitors derived from (-)-Chaetominine
期刊论文
OAI收割
JOURNAL OF MOLECULAR STRUCTURE, 2021, 卷号: 1241, 页码: 14
作者:
Zhou, Xian
;
Feng, Xuexin
;
Wang, Dachi
;
Chen, Deheng
;
Wu, Gaoxing
  |  
收藏
  |  
浏览/下载:94/0
  |  
提交时间:2021/08/17
Chaetominine
Cellular growth inhibition
Cancer cell line
Covalent warhead
Recent Progress and Clinical Development of Inhibitors that Block MDM4/p53 Protein-Protein Interactions
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 15, 页码: 10621-10640
作者:
Zhang, Shiyan
;
Lou, Jianfeng
;
Li, Yafang
;
Zhou, Feilong
;
Yan, Ziqin
  |  
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2021/11/04
A 3D Grain-Based Model for Simulating the Micromechanical Behavior of Salt Rock
期刊论文
OAI收割
ROCK MECHANICS AND ROCK ENGINEERING, 2020, 卷号: 53, 期号: 6, 页码: 2819-2837
作者:
Li, Huan
;
Ma, Hongling
;
Shi, Xilin
;
Zhou, Jun
;
Zhang, Haina
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2021/05/25
3D grain-based model
Voronoi polyhedra
Particle flow code
Rock salt
Discovery of a Potent and Selective NF-kappa B-Inducing Kinase (NIK) Inhibitor That Has Anti-inflammatory Effects in Vitro and in Vivo
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 8, 页码: 4388-4407
作者:
Li, Zhiqiang
;
Li, Xinzhi
;
Su, Ming-Bo
;
Gao, Li-Xin
;
Zhou, Yu-Bo
  |  
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2020/07/01