机构

• 上海药物研究所 [11]
• 近代物理研究所 [1]

采集方式

• OAI收割 [12]

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浏览/检索结果: 共12条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Structure-Based Drug Design of 2-Amino-[1,1′-biphenyl]-3-carboxamide Derivatives as Selective PKMYT1 Inhibitors for the Treatment of CCNE1-Amplified Breast Cancer 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 21 作者:  Wang, Chaofan;  Fang, Yan;  Zhou, Ziqin;  Liu, Zhuoheng;  Feng, Fang   |  收藏  |  浏览/下载：13/0  |  提交时间：2024/09/26 Discovery of a Covalent Inhibitor That Overcame Resistance to Venetoclax in AML Cells Overexpressing BFL-1 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 36 作者:  Lou, Jianfeng;  Zhou, Qianqian;  Lyu, Xilin;  Cen, Xinyi;  Liu, Chen   |  收藏  |  浏览/下载：6/0  |  提交时间：2024/08/22 Synthesis and biological evaluation of 4-imidazolidinone-containing compounds as potent inhibitors of the MDM2/p53 interaction 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 270, 页码: 16 作者:  Lin, Zhitong;  Liu, Chen;  Yan, Ziqin;  Cheng, Jing;  Wang, Xiancheng   |  收藏  |  浏览/下载：31/0  |  提交时间：2024/06/27 MDM2  p53  p21  Imidazolidinone  Apoptosis   Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 24, 页码: 16991-17025 作者:  Cheng, Jing;  Yan, Ziqin;  Jiang, Kailong;  Liu, Chen;  Xu, Dehua   |  收藏  |  浏览/下载：25/0  |  提交时间：2024/02/19 A chemical perspective on the modulation of TEAD transcriptional activities: Recent progress, challenges, and opportunities 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 243, 页码: 31 作者:  Lou, Jianfeng;  Lu, Yuhang;  Cheng, Jing;  Zhou, Feilong;  Yan, Ziqin   |  收藏  |  浏览/下载：42/0  |  提交时间：2022/12/13 TEAD  YAP  Palmitoylation  Protein-protein interaction  Covalent inhibitor   Discovery of a selective and covalent small-molecule inhibitor of BFL-1 protein that induces robust apoptosis in cancer cells 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 236, 页码: 114327 作者:  Feng, Xuexin;  Yan, Ziqin;  Zhou, Feilong;  Lou, Jianfeng;  Lyu, Xilin   |  收藏  |  浏览/下载：40/0  |  提交时间：2024/03/21 BFL-1  Apoptosis  Covalent inhibitor  Cytochrome c  BCL-2  Protein-Protein interaction   Synthesis and bioactivity studies of covalent inhibitors derived from (-)-Chaetominine 期刊论文  OAI收割 JOURNAL OF MOLECULAR STRUCTURE, 2021, 卷号: 1241, 页码: 14 作者:  Zhou, Xian;  Feng, Xuexin;  Wang, Dachi;  Chen, Deheng;  Wu, Gaoxing   |  收藏  |  浏览/下载：95/0  |  提交时间：2021/08/17 Chaetominine  Cellular growth inhibition  Cancer cell line  Covalent warhead   Recent Progress and Clinical Development of Inhibitors that Block MDM4/p53 Protein-Protein Interactions 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 15, 页码: 10621-10640 作者:  Zhang, Shiyan;  Lou, Jianfeng;  Li, Yafang;  Zhou, Feilong;  Yan, Ziqin   |  收藏  |  浏览/下载：41/0  |  提交时间：2021/11/04 Discovery of a novel, potent and selective small-molecule inhibitor of PD-1/PD-L1 interaction with robust in vivo anti-tumour efficacy 期刊论文  OAI收割 BRITISH JOURNAL OF PHARMACOLOGY, 2021, 页码: 20 作者:  Liu, Chenglong;  Zhou, Feilong;  Yan, Ziqin;  Shen, Lian;  Zhang, Xichen   |  收藏  |  浏览/下载：49/0  |  提交时间：2021/06/11 immunotherapy  PD-1/PD-L1  TGF-beta  tumour immune microenvironment   Discovery of a Potent and Selective NF-kappa B-Inducing Kinase (NIK) Inhibitor That Has Anti-inflammatory Effects in Vitro and in Vivo 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 8, 页码: 4388-4407 作者:  Li, Zhiqiang;  Li, Xinzhi;  Su, Ming-Bo;  Gao, Li-Xin;  Zhou, Yu-Bo   |  收藏  |  浏览/下载：42/0  |  提交时间：2020/07/01