中国科学院机构知识库网格系统: 检索

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	Discovery and optimization of novel indolecarboxylic acid derivative as potent glucagon-like peptide-1 receptor agonists 期刊论文 OAI收割 MOLECULAR DIVERSITY, 2025, 页码: 23 作者: Zhao, Wanting; Yin, Yuqian; Shi, Zhuo; Yang, Ke; Li, Xinglin \| 收藏 \| 浏览/下载：10/0 \| 提交时间：2025/07/25 GLP-1R Agonists hERG Indolecarboxylic acid derivative T2DM Obesity
	Update on the development of TGR5 agonists for human diseases 期刊论文 OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 271, 页码: 20 作者: Jin, Wangrui; Zheng, Mingyue; Chen, Yihua; Xiong, Hai \| 收藏 \| 浏览/下载：24/0 \| 提交时间：2024/07/12 Bile acids TGR5 T2DM Gut-targeted TGR5 agonists
	Synthesis, evaluation and molecular dynamics study of human toll-like receptor 2/6 specific monoacyl lipopeptides as candidate immunostimulants 期刊论文 OAI收割 BIOORGANIC CHEMISTRY, 2023, 卷号: 141, 页码: 17 作者: Zhu, Yueyue; Liu, Bo; Chen, Zonglong; Wang, Xianyang; Wang, Yujie \| 收藏 \| 浏览/下载：40/0 \| 提交时间：2023/12/08 Toll -like receptor 2/6 agonists PamCS Structure-activity relationship Lipopeptide Immunostimulants
	Small-Molecule Drugs in Immunotherapy 期刊论文 OAI收割 MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2023, 卷号: 23, 期号: 13, 页码: 1341-1359 作者: Hao,Xuanrun; Chen,Zhongliang; Li,Haining; Wei,Minqin; Zuo,Zhili \| 收藏 \| 浏览/下载：177/0 \| 提交时间：2024/07/25 Cancer immunotherapy inhibitors Pd-1/Pd-L1 inhibitor IDO inhibitor STING agonists ROR gamma t agonists TGF beta inhibitors INDOLEAMINE 2,3-DIOXYGENASE SIGNALING INHIBITOR DENDRITIC CELLS GROWTH TUMOR PATHWAY PEMBROLIZUMAB RECEPTORS DISCOVERY VADIMEZAN
	Selective ERK1/2 agonists isolated from Melia azedarach with potent anti-leukemic activity 期刊论文 OAI收割 BMC Cancer, 2019, 卷号: 19, 期号: 1 作者: Wang,Ning; Fan,Yanhua; Yuan,Chun-Mao; Song,Jialei; Yao,Yao \| 收藏 \| 浏览/下载：97/0 \| 提交时间：2019/08/13 Cancer Leukemia Chinese medicinal plant Melia azedarach Drug screen ERK1/2 agonists Differentiation Apoptosis
	Discovery of beta(2)-adrenoceptor agonists in Curcuma zedoaria Rosc using label-free cell phenotypic assay combined with two-dimensional liquid chromatography 期刊论文 OAI收割 JOURNAL OF CHROMATOGRAPHY A, 2018, 卷号: 1577, 页码: 59-65 作者: Liu, Yanfang; Liang, Xinmiao; Zhou, Weijia; Wang, Jixia; Zhao, Yaopeng \| 收藏 \| 浏览/下载：57/0 \| 提交时间：2019/06/20 Curcuma zedoaria Rosc beta(2)-adrenoceptor agonists Diarylheptanoids Label-free cell phenotypic assay Two-dimensional liquid chromatography
	Discovery of beta(2)-adrenoceptor agonists in curcuma zedoaria rosc using label-free cell phenotypic assay combined with two-dimensional liquid chromatography 期刊论文 iSwitch采集 Journal of chromatography a, 2018, 卷号: 1577, 页码: 59-65 作者: Zhou, Weijia; Wang, Jixia; Zhao, Yaopeng; Yu, Long; Fang, Ye 收藏 \| 浏览/下载：75/0 \| 提交时间：2019/05/08 Curcuma zedoaria rosc Beta(2)-adrenoceptor agonists Diarylheptanoids Label-free cell phenotypic assay Two-dimensional liquid chromatography
	Design and Synthesis of 2-Alkylpyrimidine-4,6-diol and 6-Alkylpyridine-2,4-diol as Potent GPR84 Agonists 期刊论文 OAI收割 ACS MEDICINAL CHEMISTRY LETTERS, 2016, 卷号: 7, 期号: 6, 页码: 579-583 作者: Liu, Yang; Zhang, Qing; Chen, Lin-Hai; Yang, Hui; Lu, Wei \| 收藏 \| 浏览/下载：46/0 \| 提交时间：2019/01/08 GPR84 agonists 2-alkylpyrimidine-4,6-diol 6-alkylpyridine-2,4-diol structural modification
	Discovery of novel dual functional agent as PPAR gamma agonist and 11 beta-HSD1 inhibitor for the treatment of diabetes 期刊论文 OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 卷号: 17, 期号: 15, 页码: 5722-5732 作者: Ye, Yang-liang; Zhou, Zhou; Zou, Han-jun; Shen, Yu; Xu, Ti-fei \| 收藏 \| 浏览/下载：39/0 \| 提交时间：2019/01/08 Type 2 diabetes PPAR gamma agonists 11 beta-HSD1 inhibitors Molecular modeling