中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [2426]
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Proteomics analysis of histone deacetylase inhibitor-resistant solid tumors reveals resistant signatures and potential drug combinations
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 11
作者:
Hao, Bing-bing
;
Ma, Ke
;
Xu, Jun-yu
;
Fan, Ru-feng
;
Zhao, Wen-si
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/03/25
solid tumor
histone deacetylase inhibitor
vorinostat (SAHA)
drug resistance
proteomics
Structure-Activity Relationships of 2-(Arylthio)benzoic Acid FTO Inhibitors
期刊论文
OAI收割
ISRAEL JOURNAL OF CHEMISTRY, 2024, 页码: 13
作者:
Yan, Chao
;
Zhang, Qian
;
Xiao, Pan
;
Xie, Xinyun
;
Li, Ming
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2024/03/25
RNA modification
m(6)A
FTO
anticancer
Inulin-like polysaccharide ABWW may impede CCl
4
induced hepatic stellate cell activation through mediating the FAK/PI3K/AKT signaling pathway
in vitro
&
in vivo
期刊论文
OAI收割
CARBOHYDRATE POLYMERS, 2024, 卷号: 326, 页码: 15
作者:
Dai, Xiaolan
;
Du, Zhenyun
;
Jin, Can
;
Tang, Bixi
;
Chen, Xia
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/02/19
Fructan
Hepatic fibrosis
Hepatic stellate cells
FAK/PI3K/AKT
Effects of toxin metalloproteinases from jellyfish
Nemopilema
nomurai
nematocyst on the dermal toxicity and potential treatment of jellyfish dermatitis
期刊论文
OAI收割
INTERNATIONAL IMMUNOPHARMACOLOGY, 2024, 卷号: 128, 页码: 12
作者:
Li, Aoyu
;
Yu, Huahua
;
Li, Rongfeng
;
Yue, Yang
;
Yu, Chunlin
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/04/07
Inflammation
Jellyfish dermatitis
Jellyfish envenomation
Nemopilema nomurai nematocyst venom (NnNV)
Metalloproteinase
Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses
期刊论文
OAI收割
NATURE CHEMICAL BIOLOGY, 2024, 页码: 29
作者:
Zhou, Xiaoyu
;
Zhao, Cheng
;
Xu, Haiyan
;
Xu, Yixiang
;
Zhan, Li
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/03/25
Development of Potent MALT1 Inhibitors Featuring a Novel "2-Thioxo-2,3-dihydrothiazolo[4,5-
d
]pyrimidin-7(6
H
)-one" Scaffold for the Treatment of B Cell Lymphoma
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 4, 页码: 2884-2906
作者:
Liang, Xuewu
;
Yu, Haolan
;
Liang, Renwen
;
Feng, Zhuanghui
;
Saidahmatov, Abdusaid
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/04/09
Discovery of Novel PROTAC Degraders of p300/CBP as Potential Therapeutics for Hepatocellular Carcinoma
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 4, 页码: 2466-2486
作者:
Chang, Qi
;
Li, Jiayi
;
Deng, Yue
;
Zhou, Ruilin
;
Wang, Bingwei
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/03/25
Discovery of a brain-permeable bromodomain and extra terminal domain (BET) inhibitor with selectivity for BD1 for the treatment of multiple sclerosis
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 14
作者:
Chen, Xuetao
;
Wu, Tingting
;
Du, Zhiyan
;
Kang, Wenjing
;
Xu, Rujun
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2024/02/27
BET
BD1
Bromodomain
Brain-permeable
Multiple sclerosis
Discovery of GPX4 inhibitors through FP-based high-throughput screening
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 14
作者:
Cao, Yu
;
Wu, Bin
;
Xu, Ying
;
Wang, Mingchen
;
Wu, Xinyu
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2024/02/27
GPX4 inhibitor
HTS assay
Ferroptosis
Fluorescence polarization
Discovery of a 1,6-naphthyridin-4-one-based AXL inhibitor with improved pharmacokinetics and enhanced in vivo antitumor efficacy
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 17
作者:
Lan, Yaohan
;
Peng, Xia
;
Ji, Yinchun
;
Su, Yi
;
Duan, Wenhu
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/02/27
AXL inhibitor
In vivo antitumor efficacy
6-Naphthyridin-4-one derivatives
Scaffold hopping
Structure-based drug design