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Chinese Academy of Sciences Institutional Repositories Grid
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浏览/检索结果: 共86条，第1-10条 帮助

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An LQT2-related mutation in the voltage-sensing domain is involved in switching the gating polarity of hERG 期刊论文  OAI收割
BMC BIOLOGY, 2024, 卷号: 22, 期号: 1, 页码: 14
作者:  Liu, Zhipei;  Wang, Feng;  Yuan, Hui;  Tian, Fuyun;  Yang, Chuanyan
  |  收藏  |  浏览/下载：12/0  |  提交时间：2024/03/13
Discovery and exploration of novel somatostatin receptor subtype 5 (SSTR5) antagonists for the treatment of cholesterol gallstones 期刊论文  OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 264, 页码: 16
作者:  Han, Fanghui;  Zhao, Tingting;  Zhang, Yanglong;  Yun, Ying;  Xu, Yuanyuan
  |  收藏  |  浏览/下载：1/0  |  提交时间：2024/02/19
Discovery of 5-trifluoromethyl-2-aminopyrimidine derivatives as potent dual inhibitors of FLT3 and CHK1 期刊论文  OAI收割
RSC MEDICINAL CHEMISTRY, 2023, 页码: 14
作者:  Deng, Minjie;  Gao, Yue;  Wang, Peipei;  Du, Wenjing;  Xu, Gaoya
  |  收藏  |  浏览/下载：6/0  |  提交时间：2024/02/19
Discovery of 2-Aminopyrimidine Derivatives as Potent Dual FLT3/CHK1 Inhibitors with Significantly Reduced hERG Inhibitory Activities 期刊论文  OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 23
作者:  Li, Xuemei;  Wang, Peipei;  Wang, Chang;  Jin, Tingting;  Xu, Ran
  |  收藏  |  浏览/下载：14/0  |  提交时间：2023/10/17
Discovery of a Novel Bifunctional Steroid Analog, YXG-158, as an Androgen Receptor Degrader and CYP17A1 Inhibitor for the Treatment of Enzalutamide-Resistant Prostate Cancer 期刊论文  OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 14, 页码: 9972-9991
作者:  Wang, Ao;  Luo, Xianggang;  Meng, Xin;  Lu, Zhengyu;  Chen, Kaixian
  |  收藏  |  浏览/下载：9/0  |  提交时间：2023/10/17
Discovery of Novel 5,6-Dihydro-1,2,4-triazine Derivatives as Efficacious Glucagon-Like Peptide-1 Receptor Agonists 期刊论文  OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 23
作者:  Chen, Lili;  Yun, Ying;  Guo, Shimeng;  Wang, Xiaoyan;  Xiong, Muya
  |  收藏  |  浏览/下载：9/0  |  提交时间：2023/10/17
Discovery of (S)-N-(2-Amino-4-fluorophenyl)-4-(1-(3-(4-((dimethylamino)methyl)phenyl)-6-oxopyridazin-1(6H)-yl)ethyl)benzamide as Potent Class I Selective HDAC Inhibitor for Oral Anticancer Drug Candidate 期刊论文  OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 10, 页码: 7016-7037
作者:  Li, Daqiang;  Zhang, Zhuo;  Li, Yalei;  Wang, Xinyi;  Zhong, Hanyue
  |  收藏  |  浏览/下载：18/0  |  提交时间：2023/10/17
Molecular Determinants for the High-Affinity Blockade of Human Ether-a-go-go-Related Gene K+ Channel by Tolterodine 期刊论文  OAI收割
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2022, 卷号: 80, 期号: 5, 页码: 679-689
作者:  Wang, Na;  Yang, Yang;  Wen, Jing;  Fan, Xin-Rong;  Li, Jian
  |  收藏  |  浏览/下载：25/0  |  提交时间：2022/12/13
Design, synthesis and biological evaluation of (R)-5-methylpyrrolidin-2-ones as p300 bromodomain inhibitors with Anti-Tumor activities in multiple tumor lines 期刊论文  OAI收割
BIOORGANIC CHEMISTRY, 2022, 卷号: 124, 页码: 15
作者:  Liu, Ruiqi;  Yang, Hong;  Chen, Zonglong;  Zhou, Kaixin;  Shi, Qiongyu
  |  收藏  |  浏览/下载：37/0  |  提交时间：2022/08/16
The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression 期刊论文  OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 229, 页码: 22
作者:  Li, Xiaokang;  Li, Jinwen;  Huang, Yunyuan;  Gong, Qi;  Fu, Yan
  |  收藏  |  浏览/下载：31/0  |  提交时间：2022/06/15