机构

• 上海药物研究所 [68]
• 上海神经科学研究所 [26]
• 金属研究所 [12]
• 上海生物化学与细胞... [12]
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• OAI收割 [158]

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• 期刊论文 [157]
• 会议论文 [1]

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• 2024 [4]
• 2022 [3]
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• Neuroscie... [18]
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浏览/检索结果: 共158条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序作者升序作者降序 Design, synthesis and pharmacological evaluation of 1,2,3,4-tetrahydrobenzofuro[2,3-c] pyridine derivatives as p21-activated kinase 4 inhibitors for treatment of pancreatic cancer 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 1, 页码: 438-466 作者:  Li, Yang;  Fang, Yan;  Chen, Xiaoyu;  Tong, Linjiang;  Feng, Fang   |  收藏  |  浏览/下载：16/0  |  提交时间：2025/04/01 P21-activated kinase 4  Tetrahydrobenzofuro[2  3-c]pyridine  Structure-activity relationship  Allosteric inhibitor  Pharmacokinetics properties  Kinase selectivity  Pancreatic cancer  Immune infiltration   Integrative study of lung cancer adeno-to-squamous transition in EGFR TKI resistance identifies RAPGEF3 as a therapeutic target 期刊论文  OAI收割 NATIONAL SCIENCE REVIEW, 2024, 卷号: 11, 期号: 12, 页码: 20 作者:  Wang, Hua;  Tang, Shijie;  Wu, Qibiao;  He, Yayi;  Zhu, Weikang   |  收藏  |  浏览/下载：22/0  |  提交时间：2025/02/28 EGFR-mutant lung cancer  adeno-to-squamous transition  tyrosine kinase inhibitor resistance  transcription factor network  RAPGEF3   Mass balance, metabolism, and pharmacokinetics of [14C]amdizalisib, a clinical-stage novel oral selective PI3Kδ inhibitor for the treatment of non-hodgkin's lymphoma, in healthy Chinese volunteers 期刊论文  OAI收割 FRONTIERS IN PHARMACOLOGY, 2024, 卷号: 15, 页码: 13 作者:  Zhao, Chun-Yang;  Zhang, Li-Jun;  Sun, Chan;  Yu, Cheng-Yin;  Wang, Jian   |  收藏  |  浏览/下载：13/0  |  提交时间：2025/01/06 amdizalisib  PI3K delta kinase  metabolism  mass balance  metabolite identification  pharmacokinetics  safety   Design, synthesis and evaluation of thieno[3,2-d]pyrimidine derivatives as novel potent CDK7 inhibitors 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2024, 卷号: 148, 页码: 15 作者:  Zhang, Hongjin;  Lin, Guohao;  Jia, Suyun;  Wu, Jianbo;  Zhang, Ying   |  收藏  |  浏览/下载：24/0  |  提交时间：2024/09/26 Cyclin-dependent kinase 7  Small molecular inhibitor  Triple negative breast cancer  Thieno[3,2-d]pyrimidine derivative   Discovery and optimization of thieno[3,2-d]pyrimidine derivatives as highly selective inhibitors of cyclin-dependent kinase 7 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 263, 页码: 21 作者:  Zhang, Hongjin;  Lin, Guohao;  Jia, Suyun;  Zhang, Ying;  Wu, Jianbo   |  收藏  |  浏览/下载：20/0  |  提交时间：2024/01/26 Thieno[3  d ]pyrimidine derivative  Cyclin-dependent kinase 7  Small molecule inhibitor  Kinome selectivity  Triple negative breast cancer   Structural and mechanistic insights provided by single particle cryo-EM analysis of phosphoinositide 3-kinase (PI3Ka) 期刊论文  OAI收割 BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2023, 卷号: 1878, 期号: 5, 页码: 6 作者:  Vogt, Peter K.;  Hart, Jonathan R.;  Yang, Su;  Zhou, Qingtong;  Yang, Dehua   |  收藏  |  浏览/下载：28/0  |  提交时间：2023/10/17 Phosphoinositide 3-kinase  BYL-719  Nanobody  CXMS  Mutants   Structural insights into the interaction of three Y- shaped ligands with PI3Kα 期刊论文  OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 卷号: 120, 期号: 34, 页码: 9 作者:  Zhou, Qingtong;  Liu, Xiao;  Neri, Dario;  Li, Wenxin;  Favalli, Nicholas   |  收藏  |  浏览/下载：29/0  |  提交时间：2023/12/08 phosphoinositide 3-kinase  drug target  ligand  binding pocket  chemical scaffold   Design, synthesis and pharmacological evaluation of 2,3-dihydrobenzo-furan IRAK4 inhibitors for the treatment of diffuse large B-cell lymphoma 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 256, 页码: 16 作者:  Chen, Yun;  Ning, Yi;  Chen, Zhiwei;  Xue, Yaping;  Wu, Qingyun   |  收藏  |  浏览/下载：28/0  |  提交时间：2023/10/17 Apoptosis  Diffuse large B-Cell lymphoma  Interleukin-1 receptor associated kinase 4  Structure-based drug design  2  3-Dihydrobenzofuran   Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3K alpha 期刊论文  OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 卷号: 119, 期号: 46, 页码: 11 作者:  Liu, Xiao;  Zhou, Qingtong;  Hart, Jonathan R.;  Xu, Yingna;  Yang, Su   |  收藏  |  浏览/下载：35/0  |  提交时间：2023/10/17 phosphoinositide 3-kinase (PI3K)  mass spectrometry  mutants   Nanobodies and chemical cross-links advance the structural and functional analysis of PI3K alpha 期刊论文  OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 卷号: 119, 期号: 38, 页码: 9 作者:  Hart, Jonathan R.;  Liu, Xiao   |  收藏  |  浏览/下载：32/0  |  提交时间：2023/10/17 phosphoinositide 3-kinase (PI3K)  nanobody  conformational changes  chemical cross-linking  mass spectrometry