中国科学院机构知识库网格系统: 检索

Trail Formation Alleviates Excessive Adhesion and Maintains Efficient Neutrophil Migration 期刊论文 OAI收割
ACS APPLIED MATERIALS & INTERFACES, 2023
作者: Hu WH(胡文慧); Gao WB(高文博); Gong YX(龚一心); Guo P(郭盼); Li W(李旺)

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收藏 | 浏览/下载：9/0 | 提交时间：2023/04/20

neutrophil migration trail release rear contraction fi2 integrin cell adhesion

Dual-responsive nanoparticles loading bevacizumab and gefitinib for molecular targeted therapy against non-small cell lung cancer 期刊论文 OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 11
作者: Zhao, Zi-tong; Wang, Jue; Fang, Lei; Qian, Xin-di; Cai, Ying

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收藏 | 浏览/下载：56/0 | 提交时间：2022/08/16

nanoparticles molecular targeted therapy non-small cell lung cancer dual-responsive controlled release

New synthetic adriamycin-incorporated chitosan nanoparticles with enhanced antioxidant, antitumor activities and pH-sensitive drug release 期刊论文 OAI收割
CARBOHYDRATE POLYMERS, 2021, 卷号: 273, 页码: 11
作者: Mi, Yingqi; Chen, Yuan; Gu, Guodong; Miao, Qin; Tan, Wenqiang

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收藏 | 浏览/下载：37/0 | 提交时间：2022/06/16

Chitosan Drug release Cell viability Antitumor activity

Deficiency in the membrane protein Tmbim3a/Grinaa initiates cold-induced ER stress and cell death by activating an intrinsic apoptotic pathway in zebrafish 期刊论文 OAI收割
JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 卷号: 294, 期号: 30, 页码: 11445-11457
作者: Chen, Kai; Li, Xixi; Song, Guili; Zhou, Tong; Long, Yong

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收藏 | 浏览/下载：195/0 | 提交时间：2019/09/10

endoplasmic reticulum stress (ER stress) calcium intracellular release apoptosis zebrafish stress response apoptosis calcium homeostasis cold exposure endoplasmic reticulum stress calcium homeostasis Grinaa transmembrane BAX inhibitor motif (TMBIM) unfolded protein response (UPR) cell death

Artificial anaerobic cell dormancy for tumor gaseous microenvironment regulation therapy 期刊论文 OAI收割
BIOMATERIALS, 2019, 卷号: 200, 页码: 48
作者: Chen, Chen; Su, Weiwei; Liu, Yanyan; Zhang, Jiawen; Zuo, Changjing

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收藏 | 浏览/下载：84/0 | 提交时间：2019/12/26

Gaseous microenvironment regulation Cell dormancy Hypoxia Anaerobic Controlled drug release

食用蔬菜能吸收和积累微塑料 期刊论文 OAI收割
科学通报, 2019, 卷号: 64, 期号: 9, 页码: 928-934
作者: 李连祯; 周倩; 尹娜; 涂晨; 骆永明

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收藏 | 浏览/下载：146/0 | 提交时间：2020/06/17

微塑料生菜聚苯乙烯微球吸收积累健康风险 microplastics lettuce polystyrene microbeads uptake accumulation human health risk Microplastic (MP, 100 nm-5 mm) may present an attributable risk to ecosystem and human health, and its pollution has become a global environmental concern. Despite a wealth of information on the accumulation of MPs in aquatic species, there is no information on the uptake and accumulation of MPs by higher plants. Terrestrial edible plants are directly exposed to MPs when agricultural soil was applied with organic manure, sewage sludge as fertilizer or plastic mulching. In this paper, the uptake of two sizes of polystyrene (PS) microbeads (0.2 and 1.0 mum) and then their distribution and migration in an edible plant lettuce were firstly investigated based on laboratory experiments. We used fluorescent markers to track PS microbeads in plant tissues and found fluorescence to be a sensitive and reliable detection method. Sections from untreated control lettuce showed no autofluorescence. When roots were treated with fluorescently labeled PS microbeads, the microbeads could be identified by its fluorescence. Our main study investigated the uptake of 0.2 mum beads, as few luminescence signals were observed in lettuce roots for 1.0 mum beads in our experiment. We observed that 0.2 mum fluorescent microbeads were extracellularly trapped in the root cap mucilage (which is a highly hydrated polysaccharide) and a dark green tip (which was typical of lettuce roots exposed to label PS beads) was usually visible to the naked eye. Confocal images revealed that the PS luminescence signals were mainly located in the vascular system and on the cell walls of the cortex tissue of the roots, indicated that the beads passed through the intercellular space via the apoplastic transport system. Once inside the central cylinder, the 0.2 mum PS beads were transferred from the roots to the stems and leaves via the vascular system following the transpiration stream. We also observed that the PS beads adhered to one another and self-assembled systematically into grape-like and (chain) string-like clusters in the intercellular space of the root and stem vascular tissue of lettuce plant. In contrast to the root and stem, PS beads were dispersed in the leaf tissue. Here, for the first time we provide evidence of the adherence, uptake, accumulation, and translocation of submicrometer MPs within an edible plant. Our findings highlight the previously underappreciated human exposure pathway to MPs through the consumption of contaminated crops and emphasize the need for new management strategies to control the release of MPs waste products into the terrestrial environment. Ultimately, the potential impacts of low range sized MPs on food safety of crop plants and human health need to be urgently considered.

Electrochemical Responsive Superhydrophilic Surfaces of Polythiophene Derivatives towards Cell Capture and Release 期刊论文 OAI收割
CHEMPHYSCHEM, 2018, 卷号: 19, 期号: 16, 页码: 2046-2051
作者: Hao, Yuwei; Li, Yingying; Zhang, Feilong; Cui, Haijun; Hu, Jinsong

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收藏 | 浏览/下载：45/0 | 提交时间：2019/04/09

Cell Capture And Release Electrochemical Responsive Materials Nonspecific Adhesion Smart Surfaces Thiophene Derivatives

Photo and Thermo Dual-Responsive Copolymer Surfaces for Efficient Cell Capture and Release 期刊论文 OAI收割
CHEMPHYSCHEM, 2018, 卷号: 19, 期号: 16, 页码: 2107-2112
作者: Hao, Yuwei; Liu, Hongliang; Li, Guannan; Cui, Haijun; Jiang, Lei

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收藏 | 浏览/下载：35/0 | 提交时间：2019/04/09

Cell Capture And Release Smart Surface Stimuli-responsive Material Surface Chemistry

Preparation of Porous Polylactide Microspheres and Their Application in Tissue Engineering 期刊论文 OAI收割
CHINESE JOURNAL OF POLYMER SCIENCE, 2018, 卷号: 36, 期号: 6, 页码: 712-719
作者: Shi, Xu-Dong; Sun, Pei-Jian; Gan, Zhi-Hua

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收藏 | 浏览/下载：33/0 | 提交时间：2019/04/09

Polylactide Porous Microspheres Drug Release Cell Tissue Engineering

Thermosensitive polypeptide hydrogels as a platform for ros-triggered cargo release with innate cytoprotective ability under oxidative stress 期刊论文 iSwitch采集
Advanced healthcare materials, 2016, 卷号: 5, 期号: 15, 页码: 1979-1990
作者: Xu, Qinghua; He, Chaoliang; Ren, Kaixuan; Xiao, Chunsheng; Chen, Xuesi

收藏 | 浏览/下载：61/0 | 提交时间：2019/05/09

Cell protection Oxidation-responsive hydrogel Poly(l-methionine) Thermosensitive hydrogel Triggered drug release