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	Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文 OAI收割 PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299 作者: Zeng, Guang-Zhi; Fan, Jun-Ting; Xu, Jun-Ju; Li, Yan; Tan, Ning-Hua 收藏 \| 浏览/下载：43/0 \| 提交时间：2015/05/14 2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA) one of the major components isolated from the traditional Chinese medicine Rubia yunnanensis exhibited inhibitory activity on the proliferation of several human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle arrest in human cervical carcinoma HeLa cells. Further MTA was found to induce apoptosis of HeLa cells through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and release of cytochrome c into the cytosol which caused the cleavage of caspase and poly(ADP-ribose) polymerase and finally triggered the apoptosis. Furthermore the p53/p21/Cdc2-cyclin B1 signaling was found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of R. yunnanensis a folk anti-cancer herb used in Yunnan China.
	A label-free, G-quadruplex DNAzyme-based fluorescent probe for signal-amplified DNA detection and turn-on assay of endonuclease 期刊论文 OAI收割 biosensors & bioelectronics, 2012, 卷号: 34, 期号: 1, 页码: 100-105 Zhou ZX; Du Y; Zhang LB; Dong SJ 收藏 \| 浏览/下载：31/0 \| 提交时间：2013/05/22 LINKED-IMMUNOSORBENT-ASSAY PEROXIDASE-ACTIVITY RESTRICTION ENDONUCLEASES MOLECULAR BEACONS CATALYTIC DNA CLEAVING DNA HYBRIDIZATION ENZYME CLEAVAGE COMPLEX
	Crystal structure, nano-particle morphology and interaction with ATP of [NH3 CH2CH( NH2 ) CH3 ](2) [ M( VI ) O-2 (OC6H4O)(2) ] (M = MO0.6 W-0.4) and its activity to promote DNA cleavage 期刊论文 OAI收割 CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2007, 卷号: 23, 期号: 6, 页码: 635-640 作者: Lu Xiao-ming; Pang Xiao-li; Li Zhi-qiang; Wang Ting; Wang Zhen 收藏 \| 浏览/下载：31/0 \| 提交时间：2015/10/13 crystal structure nano-particle NMR ATP DNA cleavage activity
	Enhanced catalytic DNAzyme for label-free colorimetric detection of DNA 期刊论文 OAI收割 chemical communications, 2007, 期号: 41, 页码: 4209-4211 Li T; Dong SJ; Wang EK 收藏 \| 浏览/下载：198/3 \| 提交时间：2010/07/13 TELOMERASE ACTIVITY PEROXIDASE-ACTIVITY CLEAVING DNA ENZYME COMPLEX CLEAVAGE
	Site-selective DNA cleavage by a novel complex of copper-conjugate of Phen and polyamide containing N-methylimidazole rings 期刊论文 OAI收割 bioorganic & medicinal chemistry letters, 2006, 卷号: 16, 期号: 19, 页码: 5032-5035 作者: Liu, Dan 收藏 \| 浏览/下载：25/0 \| 提交时间：2015/11/11 DNA cleaving activity ESI-mass spectrometry site-selective DNA cleavage
	Studies on chemical constituents possessing DNA cleavage activity 期刊论文 OAI收割 Chinese Traditional and Herbal Drugs, 2003, 卷号: 34, 期号: 3, 页码: 203-206 作者: Xiao Kai; Xuan Lijiang; Xu Yaming; Bai Donglu \| 收藏 \| 浏览/下载：14/0 \| 提交时间：2019/01/08 Polygonum bistorta L. water-soluble constituents DNA cleavage activity
	Novel stilbene glycosides from Polygonum multiflorum 期刊论文 OAI收割 ACTA BOTANICA SINICA, 2002, 卷号: 44, 期号: 12, 页码: 1491-1494 作者: Xiao, K; Xuan, LJ; Xu, YM; Bai, DL \| 收藏 \| 浏览/下载：17/0 \| 提交时间：2019/01/08 Polygonum multiflorum stilbene glycoside DNA cleavage activity inhibition of lipid peroxidation