机构

• 上海药物研究所 [6]
• 金属研究所 [2]

采集方式

• OAI收割 [8]

内容类型

• 期刊论文 [8]

发表日期

• 2020 [1]
• 2018 [2]
• 2017 [3]
• 2014 [1]
• 2013 [1]

学科主题

筛选

浏览/检索结果: 共8条，第1-8条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序作者升序作者降序 Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance 期刊论文  OAI收割 MOLECULAR CANCER, 2020, 卷号: 19, 期号: 1, 页码: 15 作者:  Zhang, Tao;  Qu, Rong;  Chan, Shingpan;  Lai, Mengzhen;  Tong, Linjiang   |  收藏  |  浏览/下载：96/0  |  提交时间：2020/07/01 Non-small cell lung cancer (NSCLC)  EGFR T790M  Small-molecule inhibitor  Drug resistance  Ack1   YL143, a novel mutant selective irreversible EGFR inhibitor, overcomes EGFR(L858R, T790M)-mutant resistance in vitro and in vivo 期刊论文  OAI收割 CANCER MEDICINE, 2018, 卷号: 7, 期号: 4, 页码: 1430-1439 作者:  Zhang, Zhang;  Zou, Jian;  Yu, Lei;  Luo, Jinfeng;  Li, Yan   |  收藏  |  浏览/下载：81/0  |  提交时间：2019/01/08 EGFR inhibitor  lung cancer  pharmacokinetic  selectively  T790M mutation   Synthesis and Biological Activities of Novel 2-Aminobenzimidazoles EGFR~(T790M) Inhibitors 期刊论文  OAI收割 Chinese Journal of Synthetic Chemistry, 2018, 卷号: 26, 期号: 9, 页码: 637-646 作者:  Duan Jingyi;  Zhang Yinyong;  Qian Anran;  Tong Linjiang;  Xie Hua   |  收藏  |  浏览/下载：43/0  |  提交时间：2019/01/08 1-fluoro-2-nitroarene  trans-4-aminocyclohexanol hydrochloride  2-aminobenzimidazole  EGFR~(T790M) inhibitor  synthesis  biological activity   A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFR(L858R/T790M) mutant with improved pharmacokinetic properties 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 126, 页码: 1107-1117 作者:  Yu, Lei;  Huang, Minhao;  Xu, Tianfeng;  Tong, Linjiang;  Yan, Xiao-e   |  收藏  |  浏览/下载：43/0  |  提交时间：2019/01/08 EGFR(T790M) mutant  Pyrido[2,3-d]pyrimidin-7-ones  Pharmacokinetic property  NSCLC  Irreversible inhibitor   Identification of hydrazone moiety-bearing aminopyrimidines as potent antitumor agents with selective inhibition of gefitinib-resistant H1975 cancer cells 期刊论文  OAI收割 CHINESE CHEMICAL LETTERS, 2017, 卷号: 28, 期号: 5, 页码: 991-994 作者:  Qin MingZe;  Wang Lei;  Yan Shuang;  Ma JunJie;  Tian Ye   |  收藏  |  浏览/下载：50/0  |  提交时间：2021/02/02 TYROSINE KINASE INHIBITOR  LUNG-CANCER  RECEPTOR  T790M  MUTANT  MUTATION  Aminopyrimidines  EGFR T790M/L858R  Selectivity  Anti-resistance  Antiproliferative activity   Identification of hydrazone moiety-bearing aminopyrimidines as potent antitumor agents with selective inhibition of gefitinib-resistant H1975 cancer cells 期刊论文  OAI收割 CHINESE CHEMICAL LETTERS, 2017, 卷号: 28, 期号: 5, 页码: 991-994 作者:  Qin MingZe;  Wang Lei;  Yan Shuang;  Ma JunJie;  Tian Ye   |  收藏  |  浏览/下载：56/0  |  提交时间：2021/02/02 TYROSINE KINASE INHIBITOR  LUNG-CANCER  RECEPTOR  T790M  MUTANT  MUTATION  Aminopyrimidines  EGFR T790M/L858R  Selectivity  Anti-resistance  Antiproliferative activity   Design, synthesis and biological evaluation of novel 6-alkenylamides substituted of 4-anilinothieno[2,3-d]pyrimidines as irreversible epidermal growth factor receptor inhibitors 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 卷号: 22, 期号: 7, 页码: 2366-2378 作者:  Ji, Xun;  Peng, Ting;  Zhang, Xu;  Li, Jian;  Yang, Wei   |  收藏  |  浏览/下载：48/0  |  提交时间：2019/01/08 Irreversible EGFR inhibitor  EGFR T790M/L858R  Thieno[2,3-d]pyrimidines   Design, synthesis and biological evaluation of novel 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of the epidermal growth factor receptor 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 卷号: 21, 期号: 24, 页码: 7988-7998 作者:  Zhang, Xu;  Peng, Ting;  Ji, Xun;  Li, Jian;  Tong, Linjiang   |  收藏  |  浏览/下载：40/0  |  提交时间：2019/01/08 EGFR inhibitor  EGFR T790M/L858R  Binding mode  Irreversible EGFR inhibitor