机构

• 上海药物研究所 [7]
• 青岛生物能源与过程研... [1]
• 上海生物化学与细胞生... [1]
• 合肥物质科学研究院 [1]
• 昆明动物研究所 [1]

采集方式

• OAI收割 [11]

内容类型

• 期刊论文 [11]

发表日期

• 2024 [1]
• 2019 [1]
• 2018 [2]
• 2016 [1]
• 2012 [2]
• 2011 [2]
• 更多

学科主题

• Pharmacolo... [1]
• Pharmacolo... [1]
• 支撑与管理::仿真与... [1]

筛选

浏览/检索结果: 共11条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Trametinib, an anti-tumor drug, promotes oligodendrocytes generation and myelin formation 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2024, 页码: 13 作者:  Yang, Ying;  Suo, Na;  Cui, Shi-hao;  Wu, Xuan;  Ren, Xin-yue   |  收藏  |  浏览/下载：13/0  |  提交时间：2024/07/12 oligodendrocyte differentiation  oligodendrocyte progenitor cell  remyelination  trametinib  MEK inhibitor  MEK/ERK pathway   Inhibition of MAPK/ERK pathway promotes oligodendrocytes generation and recovery of demyelinating diseases 期刊论文  OAI收割 GLIA, 2019, 卷号: 67, 期号: 7, 页码: 1320-1332 作者:  Suo, Na;  Guo, Yu-e;  He, Bingqing;  Gu, Haifeng;  Xie, Xin   |  收藏  |  浏览/下载：40/0  |  提交时间：2020/07/01 differentiation  ERK  MAPK  MEK inhibitor  myelin  oligodendrocyte  oligodendrocyte progenitor cell  remyelination   Targeting ERK, an Achilles' Heel of the MAPK pathway, in cancer therapy 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2018, 卷号: 8, 期号: 4, 页码: 552-562 作者:  Liu, Feifei;  Yang, Xiaotong;  Geng, Meiyu;  Huang, Min   |  收藏  |  浏览/下载：43/0  |  提交时间：2019/01/08 Mitogen-activated protein kinases  Extracellular signal-regulated kinase  ERK inhibitor  ERK kinase  Cancer therapy  Drug resistance   targetingerkanachillesheelofthemapkpathwayincancertherapy 期刊论文  OAI收割 actapharmaceuticasinicab, 2018, 卷号: 8, 期号: 4, 页码: 552 作者:  Liu Feifei;  Yang Xiaotong;  Geng Meiyu;  Huang Min   |  收藏  |  浏览/下载：71/0  |  提交时间：2020/07/01 Mitogen-activated protein kinases  Extracellular signal-regu lated kinase  ERK inhibitor  ERK kinase  Cancer therapy  Drug resistance   Discovery and structure activity relationship study of novel indazole amide inhibitors for extracellular signal-regulated kinase1/2 (ERK1/2) 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 卷号: 26, 期号: 11, 页码: 2600-2604 作者:  Li, Lei;  Liu, Feifei;  Jin, Nan;  Tang, Shuai;  Chen, Zhuxi   |  收藏  |  浏览/下载：18/0  |  提交时间：2019/01/08 ERK1/2 kinase inhibitor  Indazole amide  Structure based drug design   Computation of relative binding free energy for an inhibitor and its analogs binding with Erk kinase using thermodynamic integration MD simulation 期刊论文  OAI收割 J Comput Aided Mol Des., 2012, 卷号: 26, 期号: 10, 页码: 1159-69 Kuan-Wei Wu; Po-Chin Chen; Jun Wang; Ying-Chieh Sun 收藏  |  浏览/下载：21/0  |  提交时间：2012/11/12 Thermodynamic integration – MD simulation – Relative binding free energy – Erk kinase – Inhibitor   The crossregulation between ERK and PI3K signaling pathways determines the tumoricidal efficacy of MEK inhibitor 期刊论文  OAI收割 JOURNAL OF MOLECULAR CELL BIOLOGY, 2012, 卷号: 4 -   |  收藏  |  浏览/下载：27/0  |  提交时间：2020/10/26 KINASE KINASE-1/2 INHIBITOR  PHOSPHOINOSITIDE 3-KINASE-GAMMA  ADVANCED CANCERS  LUNG-CANCER  CELL LUNG  PHASE-II  RESISTANCE  ROBUSTNESS  ACTIVATION  MUTATIONS  systems biology  mathematical model  ERK pathway  PI3K pathway  MEK inhibitor  resistance  robustness  biochemical control analysis   ERK1/2 activation plays important roles in the opposite effects of Trichostatin A in non-cancer and cancer cells 期刊论文  OAI收割 TOXICON, 2011, 卷号: 57, 期号: 6, 页码: 932-937 作者:  Zhang, Y;  Yu, GY;  Wang, DM;  Hu, Y;  Lei, WW 收藏  |  浏览/下载：14/0  |  提交时间：2015/07/22 HDAC inhibitor  TSA  Apoptosis  ERK1/2  Non-cancer cells  Cancer cells   ERK1/2 activation plays important roles in the opposite effects of Trichostatin A in non-cancer and cancer cells 期刊论文  OAI收割 TOXICON, 2011, 卷号: 57, 期号: 6, 页码: 932-937 作者:  Zhang Y;  Yu GY;  Wang DM;  Hu Y;  Lei WW[*] 收藏  |  浏览/下载：26/0  |  提交时间：2011/06/13 HDAC inhibitor  TSA  Apoptosis  ERK1/2