机构

• 上海药物研究所 [21]
• 昆明植物研究所 [6]
• 地球化学研究所 [1]

采集方式

• OAI收割 [28]

内容类型

• 期刊论文 [25]
• 学位论文 [2]
• 会议论文 [1]

发表日期

• 2024 [3]
• 2023 [3]
• 2022 [3]
• 2021 [2]
• 2019 [1]
• 2018 [5]
• 更多

学科主题

• Pharmacolo... [3]
• Chemistry [2]
• Medicinal [1]
• Plant Scie... [1]

筛选

浏览/检索结果: 共28条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Gardenia jasminoides Ellis. Polysaccharides Alleviated Cholestatic Liver Injury by Increasing the Production of Butyric Acid and FXR Activation 期刊论文  OAI收割 PHYTOTHERAPY RESEARCH, 2024, 页码: 13 作者:  Wang, Tianming;  Tian, Tian;  Zhu, Zhenyun;  Fang, Su;  Zhang, Lincong   |  收藏  |  浏览/下载：18/0  |  提交时间：2024/10/21 bile acid  butyric acid  cholestasis  FXR  Gardenia jasminoides Ellis. polysaccharide  intestinal bacterial metabolite   Biotransformation of chenodeoxycholic acid by human intestinal fungi and the agonistic effects on FXR 期刊论文  OAI收割 PHYTOCHEMISTRY, 2024, 卷号: 224, 页码: 10 作者:  Wei, Xuemei;  Yao, Changliang;  He, Xin;  Li, Jiayuan;  Wang, Yulu   |  收藏  |  浏览/下载：26/0  |  提交时间：2024/07/12 Chenodeoxycholic acid  Biotransformation  Intestinal fungi  FXR   FXR activation remodels hepatic and intestinal transcriptional landscapes in metabolic dysfunction-associated steatohepatitis 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2024, 页码: 15 作者:  Wen, Ying-quan;  Zou, Zi-yuan;  Zhao, Guan-guan;  Zhang, Meng-jiao;  Zhang, Yong-xin   |  收藏  |  浏览/下载：7/0  |  提交时间：2024/08/22 MASLD/MASH  FXR  transcriptome  gut-liver axis  agonist   Saikosaponins regulate bile acid excretion in mice liver and ileum by activating farnesoid X receptor and bile acid transporter 期刊论文  OAI收割 PHYTOTHERAPY RESEARCH, 2023, 页码: 15 作者:  Wang, YuKun;  Li, Jing;  Wu, Li;  Qin, XueMei;  Xie, Cen   |  收藏  |  浏览/下载：44/0  |  提交时间：2023/10/17 bile acids  enterohepatic circulation  FXR-related genes  saikosaponins   ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer pathology through FXR1-dependent BACE1 translation initiation 期刊论文  OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 卷号: 120, 期号: 22, 页码: e2220148120 作者:  Zhou,Gui-Feng;  Tang,Jing;  Ma,Yuan-Lin;  Fu,Xian;  Liu,Jun-Yan   |  收藏  |  浏览/下载：16/0  |  提交时间：2024/05/09 conophylline  ARL6IP1  5'UTR  FXR1  BACE1 translation  AMYLOID PRECURSOR PROTEIN  A-BETA  TRANSGENIC MICE  MOUSE MODEL  NEURODEGENERATION  EXPRESSION  REDUCTION  MEMBRANE  MEMORY  ER   Celastrol as an intestinal FXR inhibitor triggers tripolide-induced intestinal bleeding: Underlying mechanism of gastrointestinal injury induced by Tripterygium wilfordii 期刊论文  OAI收割 PHYTOMEDICINE, 2023, 卷号: 121, 页码: 155054 作者:  Dai,Manyun;  Peng,Wan;  Lin,Lisha;  Wu,Zhanxuan;  Zhang,Ting   |  收藏  |  浏览/下载：9/0  |  提交时间：2024/07/17 Intestinal bleeding  Triptolide  Celastrol  Intestinal FXR  Tripterygium wilfordii  FARNESOID-X-RECEPTOR  BACTERIAL TRANSLOCATION  ACTIVATION  INFLAMMATION  DYSFUNCTION  TRIPTOLIDE  MICROBIOTA  PREVENTS  OBESITY  MICE   雷公藤制剂对消化系统的毒性机理研究 学位论文  OAI收割 : 中国科学院大学, 2022 作者:  代曼云   |  收藏  |  浏览/下载：6/0  |  提交时间：2024/05/14 代谢组学，雷公藤，药源性肝损伤，消化性溃疡，FXR，ET-1， 肠道血管屏障  Metabolomics, Tripterygium wilfordii, Drug-induced liver injury, peptic ulcer disease, FXR, ET-1, intestinal vascular barrier.   Farnesoid X receptor (FXR) agonists induce hepatocellular apoptosis and impair hepatic functions via FXR/SHP pathway 期刊论文  OAI收割 ARCHIVES OF TOXICOLOGY, 2022, 页码: 15 作者:  Zhang, Tianwei;  Feng, Shanshan;  Li, Jiahuan;  Wu, Zhitao;  Deng, Qiangqiang   |  收藏  |  浏览/下载：59/0  |  提交时间：2022/06/15 FXR agonist  Hepatotoxicity  Farnesoid X receptor  Obeticholic acid  Px-102  Apoptosis   Intestinal farnesoid X receptor signaling controls hepatic fatty acid oxidation 期刊论文  OAI收割 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2022, 卷号: 1867, 期号: 2, 页码: 13 作者:  Lu, Dasheng;  Liu, Yameng;  Luo, Yuhong;  Zhao, Jie;  Feng, Chao   |  收藏  |  浏览/下载：76/0  |  提交时间：2022/01/18 Fatty acid oxidation  Acylcarnitines  FXR  FGF15/19  PGC1 alpha  Transcriptomics  Metabolomics   Discovery of novel ketoxime ether derivatives with potent FXR agonistic activity, oral effectiveness and high liver/blood ratio 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 43, 页码: 13 作者:  Tang, Xuehang;  Ning, Mengmeng;  Ye, Yangliang;  Gu, Yipei;  Yan, Hongyi   |  收藏  |  浏览/下载：47/0  |  提交时间：2021/11/04 FXR agonist  Ketoxime ether  Target genes  Liver  blood ratio  Systemic activation