机构

• 上海药物研究所 [2]
• 金属研究所 [1]
• 心理研究所 [1]
• 昆明植物研究所 [1]
• 近代物理研究所 [1]

采集方式

• OAI收割 [6]

内容类型

• 期刊论文 [6]

发表日期

• 2019 [1]
• 2018 [1]
• 2015 [1]
• 2013 [1]
• 2011 [1]
• 2009 [1]
• 更多

学科主题

• Oncology [1]

筛选

浏览/检索结果: 共6条，第1-6条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序作者升序作者降序题名升序题名降序发表日期升序发表日期降序 trailbasedgenedeliveryandtherapeuticstrategies 期刊论文  OAI收割 actapharmacologicasinica, 2019, 卷号: 40, 期号: 11, 页码: 1373 作者:  Zhong Huihai;  Wang Huiyuan;  Li Jian;  Huang Yongzhuo   |  收藏  |  浏览/下载：22/0  |  提交时间：2020/07/01 APOPTOSIS-INDUCING LIGAND  MESENCHYMAL STEM-CELLS  PROSTATE-CANCER CELLS  DEATH RECEPTOR 5  CO-DELIVERY  IN-VIVO  MEDIATED APOPTOSIS  ANTITUMOR-ACTIVITY  TUMORICIDAL ACTIVITY  PROTEIN EXPRESSION  TRAIL  gene delivery  gene therapy  DNA  drug delivery systems  non-viral vectors  cancer therapy   Fragmentation level determines mitochondrial damage response and subsequently the fate of cancer cells exposed to carbon ions 期刊论文  OAI收割 RADIOTHERAPY AND ONCOLOGY, 2018, 卷号: 129, 页码: 75-83 作者:  Li, Qiang;  Shen, Guosheng;  Liu, Xiongxiong;  Li, Ping;  Hirayama, Ryoichi   |  收藏  |  浏览/下载：51/0  |  提交时间：2018/12/12 Mitochondrial fragmentation  Mitophagy  Mitochondrion-mediated apoptosis  Autophagy  High-LET carbon ion radiation   Fibroblast growth factor (FGF21) protects mouse liver against D-galactose-induced oxidative stress and apoptosis via activating Nrf2 and PI3K/Akt pathways 期刊论文  OAI收割 MOLECULAR AND CELLULAR BIOCHEMISTRY, 2015, 卷号: 403, 期号: 1-2, 页码: 287-299 作者:  Yu, Yinhang;  Bai, Fuliang;  Liu, Yaonan;  Yang, Yongbi;  Yuan, Qingyan 收藏  |  浏览/下载：76/0  |  提交时间：2015/09/08 FGF21  D-Gal  Nrf2-mediated antioxidant capacity  PI3K/AKT  Apoptosis   Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文  OAI收割 PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299 作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua 收藏  |  浏览/下载：52/0  |  提交时间：2015/05/14 2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA)  one of the major components isolated from the traditional  Chinese medicine Rubia yunnanensis  exhibited inhibitory activity on the proliferation of several  human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay  and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle  arrest in human cervical carcinoma HeLa cells. Further  MTA was found to induce apoptosis of HeLa cells  through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and  release of cytochrome c into the cytosol  which caused the cleavage of caspase and poly(ADP-ribose)  polymerase and finally triggered the apoptosis. Furthermore  the p53/p21/Cdc2-cyclin B1 signaling was  found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of  cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused  the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of  R. yunnanensis  a folk anti-cancer herb used in Yunnan  China.   Reactive oxygen species contribute to oridonin-induced apoptosis and autophagy in human cervical carcinoma HeLa cells 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2011, 卷号: 32, 期号: 10, 页码: 1266-1275 作者:  Zhang Yahong;  Wu Yingliang;  Tashiro Shinichi;  Onodera Satoshi;  Ikejima Takashi   |  收藏  |  浏览/下载：18/0  |  提交时间：2021/02/02 MITOCHONDRIAL PERMEABILITY TRANSITION  OXIDATIVE STRESS  MEDIATED AUTOPHAGY  CANCER  DEATH  ACTIVATION  MECHANISM  EXPRESSION  GENERATION  INDUCTION  oridonin  reactive oxygen species  apoptosis  autophagy  Bax  Bcl-2  caspase 3  caspase 8  HeLa cell