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浏览/检索结果: 共209条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择发表日期升序发表日期降序题名升序题名降序提交时间升序提交时间降序作者升序作者降序 Impact of electrostatic distribution in CYP3A4 on the regioselectivity of triazolam metabolism and regulation of its metabolic rate by the iron spin states: Insights from MD simulations and QM calculations 期刊论文  OAI收割 JOURNAL OF INORGANIC BIOCHEMISTRY, 2026, 卷号: 276, 页码: 12 作者:  Zhao, Yan;  Ma, Xinyu;  Zheng, Qingchuan   |  收藏  |  浏览/下载：1/0  |  提交时间：2026/01/29 Triazolam  Cytochrome P450 enzyme  Regioselectivity  Metabolic mechanism  MD simulation  QM calculation   Mechanism of hydroxamic acid group metabolism to carboxylic acid: Oxidation versus hydrolysis 期刊论文  OAI收割 DRUG METABOLISM AND DISPOSITION, 2025, 卷号: 53, 期号: 10, 页码: 11 作者:  Huang, Xiyue;  Zhou, Lei;  Chen, Huixian;  Sun, Xiaowei;  Cao, Mengyi   |  收藏  |  浏览/下载：2/0  |  提交时间：2025/12/04 Hydroxamic acid group  Bisthianostat  HDAC inhibitor  Cytochrome P450 enzymes  Oxidative cleavage   Pharmacokinetics, mass balance, and metabolism of [14C]SAF-189s, a potent anaplastic lymphoma kinase/c-ROS proto-oncogene 1 inhibitor in humans: Metabolism potentially affected by interaction of cytochrome P450 enzymes and intestinal microbiota 期刊论文  OAI收割 DRUG METABOLISM AND DISPOSITION, 2025, 卷号: 53, 期号: 9, 页码: 14 作者:  Yang, Ming;  Diao, Lei;  Yan, Shu;  Tan, Yan;  Liu, Donghui   |  收藏  |  浏览/下载：1/0  |  提交时间：2025/12/04 [C-14]SAF-189s  SAF-189s metabolism and pharmacokinetics  Non-small cell lung cancer  ALK/ROS1 inhibitor  Intestinal flora  P450 enzymes   Discovery of (±)-Penindolenes Reveals an Unusual Indole Ring Cleavage Pathway Catalyzed by P450 Monooxygenase 期刊论文  OAI收割 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2024, 页码: 9 作者:  Meng, Ling-Hong;  Awakawa, Takayoshi;  Li, Xiao-Ming;  Quan, Zhiyang;  Yang, Sui-Qun   |  收藏  |  浏览/下载：37/0  |  提交时间：2024/08/29 Fungal natural products  Indole alkaloid  biosynthesis  Heterologous expression  Cytochrome P450 oxidase   Functional analysis of CYP71AV1 reveals the evolutionary landscape of artemisinin biosynthesis 期刊论文  OAI收割 FRONTIERS IN PLANT SCIENCE, 2024, 卷号: 15, 页码: 9 作者:  Chen, Fang-Yan;  Mu, Qiu-Yan;  Xu, Bing-Yi;  Lei, Yu-Chen;  Liu, Hui-Ying   |  收藏  |  浏览/下载：63/0  |  提交时间：2024/05/07 artemisinin  Asteraceae sesquiterpene lactone  cytochrome P450 monooxygenases  amorpha-4  11-diene oxidase  germacrene A oxidase  molecular evolution  loss-of-function event   Design, synthesis and biological evaluation of chalcone derivatives as potent and orally active hCYP3A4 inhibitors 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023, 卷号: 95, 页码: 9 作者:  Lu, Shiwei;  Zhang, Feng;  Gong, Jiahao;  Huang, Jian;  Zhu, Guanghao   |  收藏  |  浏览/下载：79/0  |  提交时间：2023/12/08 Cytochrome P450 3A4 (CYP3A4)  Inhibitors  Isoquinoline chalcones  Orally active   Improved 2α-Hydroxylation Efficiency of Steroids by CYP154C2 Using Structure-Guided Rational Design 期刊论文  OAI收割 APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2023, 卷号: 89, 期号: 3 作者:  Gao, Qilin;  Ma, Bingbing;  Wang, Qianwen;  Zhang, Hao;  Fushinobu, Shinya   |  收藏  |  浏览/下载：67/0  |  提交时间：2024/03/27 P450  testosterone  androstenedione  crystal structure  rational design   A Mushroom P450-Monooxygenase Enables Regioand Stereoselective Biocatalytic Synthesis of Epoxycyclohexenones 期刊论文  OAI收割 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2023, 卷号: 62, 期号: 49 作者:  Yang,Yan-Long;  Zhou,Man;  Yang,Lin;  Gressler,Markus;  Rassbach,Johannes   |  收藏  |  浏览/下载：46/0  |  提交时间：2024/07/10 Biocatalysis  Biosynthesis  Cytochrome P450  Epoxycyclohexenone  Natural Products  OPPOSITE FACIAL SPECIFICITY  NATURAL-PRODUCTS  STREPTOMYCES LL-C10037  BIOSYNTHESIS  EPOXYQUINONE  CYTOCHROME-P450  FERMENTATION  PANEPOXYDONE  EPOXIDATION  INHIBITION   A Novel CYP4 Gene Identified in the Polychaete Sternaspis scutata and Its Transcriptional Levels along the Coasts of the Liaodong Peninsula 期刊论文  OAI收割 WATER, 2022, 卷号: 14, 期号: 21, 页码: 12 作者:  Yu, Zhenglin;  Qi, Aimin;  Wang, Lili;  Shan, Encui;  Li, Dongmei   |  收藏  |  浏览/下载：36/0  |  提交时间：2024/11/15 cytochrome P450  polychaetes  Sternaspis sculata  transcriptional response  PAHs  field study   A Novel CYP4 Gene Identified in the Polychaete Sternaspis scutata and Its Transcriptional Levels along the Coasts of the Liaodong Peninsula 期刊论文  OAI收割 WATER, 2022, 卷号: 14, 期号: 21, 页码: 12 作者:  Yu, Zhenglin;  Qi, Aimin;  Wang, Lili;  Shan, Encui   |  收藏  |  浏览/下载：68/0  |  提交时间：2023/08/17 cytochrome P450  polychaetes  Sternaspis sculata  transcriptional response  PAHs  field study