中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
大连化学物理研究所 [18]
上海药物研究所 [9]
中国科学院大学 [1]
长春应用化学研究所 [1]
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OAI收割 [28]
iSwitch采集 [1]
内容类型
期刊论文 [22]
会议论文 [7]
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2023 [2]
2022 [1]
2021 [1]
2018 [3]
2017 [1]
2015 [2]
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学科主题
物理化学 [8]
生物药物学 [1]
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Design, synthesis and biological evaluation of chalcone derivatives as potent and orally active hCYP3A4 inhibitors
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023, 卷号: 95, 页码: 9
作者:
Lu, Shiwei
;
Zhang, Feng
;
Gong, Jiahao
;
Huang, Jian
;
Zhu, Guanghao
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/12/08
Cytochrome P450 3A4 (CYP3A4)
Inhibitors
Isoquinoline chalcones
Orally active
Pharmacokinetics,mass balance,and metabolism of 14C TPN171,a novel PDE5 inhibitor,in humans for the treatment of pulmonary arterial hypertension
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 卷号: 44, 期号: 1, 页码: 221
作者:
He Yifei
;
Liu Yin
;
Yu Jinghua
;
Cheng Huan
;
Odilov Abdullajon
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2023/05/22
TPN171
14CTPN171
PDE5 inhibitor
pulmonary arterial hypertension
healthy volunteers
pharmacokinetics
metabolite identification
mass balance
Pharmacokinetics, mass balance, and metabolism of [C-14]TPN171, a novel PDE5 inhibitor, in humans for the treatment of pulmonary arterial hypertension
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 13
作者:
He, Yi-fei
;
Liu, Yin
;
Yu, Jing-hua
;
Cheng, Huan
;
Odilov, Abdullajon
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2022/08/16
TPN171
[C-14]TPN171
PDE5 inhibitor
pulmonary arterial hypertension
healthy volunteers
pharmacokinetics
metabolite identification
mass balance
Furmonertinib (Alflutinib, AST2818) is a potential positive control drug comparable to rifampin for evaluation of CYP3A4 induction in sandwich-cultured primary human hepatocytes
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Wu, Ya-li
;
Xue, Ya-ru
;
Guo, Zi-tao
;
Chen, Zhen-dong
;
Ge, Xin-yu
  |  
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2021/08/17
furmonertinib (alflutinib
AST2818)
quantitative proteomics
sandwich-cultured human hepatocytes
CYP3A4 inducer and inhibitor strongly affect the pharmacokinetics of triptolide and its derivative in rats
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 8, 页码: 1386-1392
作者:
Xu, Ye
;
Zhang, Yi-fan
;
Chen, Xiao-yan
;
Zhong, Da-fang
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2019/01/08
triptolide
(5R)-5-hydroxytriptolide
CYP3A4
ritonavir
dexamethasone
pharmacokinetics
immunosuppressant
traditional Chinese medicine
Pharmacokinetic Drug Interactions of Apatinib With Rifampin and Itraconazole
期刊论文
OAI收割
JOURNAL OF CLINICAL PHARMACOLOGY, 2018, 卷号: 58, 期号: 3, 页码: 347-356
作者:
Liu, Xiaoyun
;
Zhang, Yifan
;
Chen, Qian
;
Zhan, Yan
;
Wang, Quanren
  |  
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2019/01/08
apatinib
rifampin
itraconazole
drug-drug interaction
pharmacokinetics
cyp3a4inducerandinhibitorstronglyaffectthepharmacokineticsoftriptolideanditsderivativeinrats
期刊论文
OAI收割
actapharmacologicasinica, 2018, 卷号: 039, 期号: 008, 页码: 1386
作者:
Xu Ye
;
Zhang Yifan
;
Chen Xiaoyan
;
Zhong Dafang
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2020/07/01
衍生物
老鼠
CYP3a
风湿性关节炎
新陈代谢
相互作用
细胞色素
P450
Inhibition of human CYP3A4 and CYP3A5 enzymes by gomisin C and gomisin G, two lignan analogs derived from Schisandra chinensis
期刊论文
OAI收割
FITOTERAPIA, 2017, 卷号: 119, 页码: 26-31
作者:
Zhao, Jin
;
Sun, Tao
;
Wu, Jing-Jing
;
Cao, Yun-Feng
;
Fang, Zhong-Ze
  |  
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2017/10/29
Gomisin c
Gomisin g
Cyp3a4
Cyp3a5
Inhibition
Herb-drug Interactions
Inhibition of human cytochrome P450 enzymes by licochalcone A, a naturally occurring constituent of licorice
期刊论文
OAI收割
toxicology in vitro, 2015, 卷号: 29, 期号: 7, 页码: 1569-1576
作者:
He, Wei
;
Wu, Jing-Jing
;
Ning, Jing
;
Hou, Jie
;
Xin, Hong
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2015/11/17
Licochalcone A (LCA)
Human liver microsomes (HLMs)
Cytochrome P450 enzymes (CYPs)
Inhibition
Herb-drug interactions (HDIs)
A Mechanism-Based Model for the Prediction of the Metabolic Sites of Steroids Mediated by Cytochrome P450 3A4
期刊论文
OAI收割
international journal of molecular sciences, 2015, 卷号: 16, 期号: 7, 页码: 14677-14694
作者:
Dai, Zi-Ru
;
Ai, Chun-Zhi
;
Ge, Guang-Bo
;
He, Yu-Qi
;
Wu, Jing-Jing
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2015/11/17
CYP3A4
steroids
metabolic site
mechanism-based prediction
activation energy