中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [8]
上海神经科学研究所 [3]
上海微系统与信息技术... [2]
合肥物质科学研究院 [2]
长春光学精密机械与物... [1]
广州生物医药与健康研... [1]
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OAI收割 [25]
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期刊论文 [21]
学位论文 [3]
会议论文 [1]
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2025 [1]
2024 [1]
2019 [1]
2018 [1]
2017 [1]
2016 [2]
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分析化学与药物化学 [1]
生物化学与分子生物学 [1]
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Discovery of novel covalent stabilizers for p53 Y220C using structure-based drug discovery methods
期刊论文
OAI收割
MOLECULAR DIVERSITY, 2025, 页码: 14
作者:
Wen, Yiming
;
Xu, Peijia
;
Chen, Yijie
;
Meng, Jingyi
;
Zheng, Mingyue
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2025/04/01
p53 Y220C
Covalent stabilizer
Virtual screening
Molecular dynamics
DNA binding
Structure-activity relationship
Cancer therapy
Transcriptomic Landscape Analysis Reveals a Persistent DNA Damage Response in Metabolic Dysfunction-associated Steatohepatitis Post-dietary Intervention
期刊论文
OAI收割
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY, 2024, 页码: 15
作者:
Zou, Zi-Yuan
;
Ren, Tian-Yi
;
Jiao, Ting-Ying
;
Wang, Meng-Yu
;
Huang, Lei-Jie
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/09/26
Apoptosis
DNA Damage
Metabolic dysfunction-associated stea- totic liver disease
RNA-Seq
Tumor suppressor protein P53
Western Diets
dynamicmodificationsofbiomacromoleculesmechanismandchemicalinterventions
期刊论文
OAI收割
sciencechinalifesciences, 2019, 卷号: 62, 期号: 11, 页码: 1459
作者:
Wang Chu
;
Zou Peng
;
Yang Caiguang
;
Liu Lei
;
Cheng Liang
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/07/01
POSTTRANSLATIONAL MODIFICATIONS
PROTEIN LIPIDATION
DNA METHYLATION
TARGET
IDENTIFICATION
GLYCOSYLATION
CHEMISTRY
HEALTH
DYRK2
P53
chemical biology
biomacromolecule
dynamic modification
modification analysis
chemical intervention
New tanshinone I derivatives S222 and S439 similarly inhibit topoisomerase I/II but reveal different p53-dependency in inducing G2/M arrest and apoptosis
期刊论文
OAI收割
BIOCHEMICAL PHARMACOLOGY, 2018, 卷号: 154, 页码: 255-264
作者:
Tian, Qian-Ting
;
Ding, Chun-Yong
;
Song, Shan-Shan
;
Wang, Ying-Qing
;
Zhang, Ao
  |  
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2019/01/08
Tanshinone-1
S222
S439
Anticancer targets
DNA topoisomerases
P53
1256dianhydrogalactitolinhibitshumangliomacellgrowthinvivoandinvitrobyarrestingthecellcycleatg2mphase
期刊论文
OAI收割
actapharmacologicasinica, 2017, 卷号: 38, 期号: 4, 页码: 561
作者:
Peng Chun
;
Ql Xinming
;
Miao Lingling
;
Ren Jin
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/01
NEWLY-DIAGNOSED GLIOBLASTOMA
DNA-DAMAGE
RANDOMIZED-TRIAL
DIANHYDROGALACTITOL
TEMOZOLOMIDE
P53
CANCER
TUMORS
BEVACIZUMAB
COMBINATION
1,2:5,6-dianhydrogalactitol
human glioblastoma
cell cycle arrest
p53-p21 cascade
CDC25C-CDK1 cascade
radiosensitivity
xenografted tumors
The Roles of 53BP1 in DNA Double-strand Breaks Repair
期刊论文
OAI收割
Chinese Journal of Biochemistry and Molecular Biology, 2016, 卷号: 32, 期号: 12, 页码: 1279-1285
作者:
Jiang Yuejing
;
Zang Yi
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
tumor suppressor p53 binding protein 1
DNA double-strand breaks
DNA damage repair
53bp1与dna双链断裂损伤修复
期刊论文
OAI收割
中国生物化学与分子生物学报, 2016, 卷号: 32, 期号: 12, 页码: 1279
作者:
江越菁
;
臧奕
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/07/01
肿瘤抑癌基因p53结合蛋白1
DNA双链断链
DNA损伤修复
Hairpin assembly-triggered cyclic activation of a DNA machine for label-free and ultrasensitive chemiluminescence detection of DNA
期刊论文
OAI收割
Biosensors and Bioelectronics, 2015, 卷号: 68, 页码: 550-555
作者:
Chen J(陈佳)
;
Qiu HD(邱洪灯)
;
Zhang ML(张明亮)
;
Gu TN(顾桐年)
;
Shao SJ(邵士俊)
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2015/03/11
P53 DNA
Hairpin assembly
DNA machine
Label-free
Chemiluminescence
Codelivery of Antitumor Drug and Gene by a pH-Sensitive Charge-Conversion System
期刊论文
OAI收割
acs applied materials & interfaces, 2015, 卷号: 7, 期号: 5, 页码: 3207-3215
作者:
Guan,Xiuwen
;
Li,Yanhui
;
Jiao,Zixue
;
Lin,Lin
;
Chen,Jie
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2016/05/04
LOW-MOLECULAR-WEIGHT
BREAST-TUMOR CELLS
IN-VIVO
ANTICANCER DRUGS
CO-DELIVERY
P53
DOXORUBICIN
DNA
THERAPY
POLYETHYLENIMINE
An Old Story Retold: Loss of G1 Control Defines A Distinct Genomic Subtype of Esophageal Squamous Cell Carcinoma
期刊论文
OAI收割
GENOMICS PROTEOMICS & BIOINFORMATICS, 2015, 卷号: 13
-
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/10/26
RECURRENT SOMATIC MUTATIONS
ONCOGENE-INDUCED SENESCENCE
YES-ASSOCIATED PROTEIN
COPY-NUMBER ALTERATION
DNA-DAMAGE RESPONSE
GENE-EXPRESSION
WIDE ANALYSIS
CANCER
INSTABILITY
P53