中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [4]
植物研究所 [1]
采集方式
OAI收割 [5]
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Identification of [1,2,4]Triazolo[4,3-a]pyrazine PARP1 inhibitors with overcome acquired resistance activities
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 259, 页码: 19
作者:
Wang, Pingyuan
;
Zhu, Wen-Ting
;
Wang, Yajing
;
Song, Shan-Shan
;
Xi, Yong
  |  
收藏
  |  
浏览/下载:72/0
  |  
提交时间:2023/10/17
PARP1 inhibitor
Synthetic lethality
Drug resistance
Anticancer
Structure -activity relationship
Poly ADP-ribose polymerase-1 promotes seed-setting rate by facilitating gametophyte development and meiosis in rice (Oryza sativa L.)
期刊论文
OAI收割
PLANT JOURNAL, 2021, 卷号: 107, 期号: 3, 页码: 760-774
作者:
Li, Xiumei
;
Zhang, Yixin
;
Liu, Qinjian
;
Song, Songquan
;
Liu, Jun
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2023/02/24
poly(ADP-ribose) polymerases
seed-setting rate
gametophyte development
meiosis
PARP activity
DNA damage
Phase I dose-escalation and expansion study of PARP inhibitor, fluzoparib (SHR3162), in patients with advanced solid tumors
期刊论文
OAI收割
CHINESE JOURNAL OF CANCER RESEARCH, 2020, 卷号: 32, 期号: 3, 页码: 370-+
作者:
Li, Huiping
;
Liu, Rongrui
;
Shao, Bin
;
Ran, Ran
;
Song, Guohong
  |  
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2020/12/24
Phase I
PARP inhibitor (fluzoparib)
solid tumor
pharmacokinetics
safety
antitumor activity
Increased PARP1-DNA binding due to autoPARylation inhibition of PARP1 on DNA rather than PARP1-DNA trapping is correlated with PARP1 inhibitor's cytotoxicity
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF CANCER, 2019, 卷号: 145, 期号: 3, 页码: 714-727
作者:
Chen, Hua-Dong
;
Chen, Chuan-Huizi
;
Wang, Yu-Ting
;
Guo, Ne
;
Tian, Yu-Nan
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/03/21
PARP1 inhibitor
PARP1-DNA binding
PARP1-DNA trapping
poly(ADP-ribose) polymerase activity
cytotoxicity
Novel PARP1/2 inhibitor mefuparib hydrochloride elicits potent in vitro and in vivo anticancer activity, characteristic of high tissue distribution
期刊论文
OAI收割
ONCOTARGET, 2017, 卷号: 8, 期号: 3, 页码: 4156-4168
作者:
He, Jin-Xue
;
Wang, Meng
;
Huan, Xia-Juan
;
Chen, Chuan-Huizi
;
Song, Shan-Shan
  |  
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2019/01/08
MPH
PARP inhibitor
homologous recombination
antitumor activity
synthetic lethality