机构

• 上海药物研究所 [15]
• 上海神经科学研究所 [3]
• 上海生物化学与细胞生... [3]
• 合肥物质科学研究院 [3]
• 宁波材料技术与工程研... [2]
• 生物物理研究所 [1]
• 更多

采集方式

• OAI收割 [29]

内容类型

• 期刊论文 [28]
• 会议论文 [1]

发表日期

• 2024 [1]
• 2022 [2]
• 2021 [1]
• 2020 [2]
• 2019 [2]
• 2018 [5]
• 更多

学科主题

• Biochemist... [2]
• Cell Biolo... [2]
• Developmen... [2]
• Biochemist... [1]
• Biochemist... [1]
• Chemistry [1]
• 更多

筛选

浏览/检索结果: 共29条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Mass balance, metabolism, and pharmacokinetics of [14C]amdizalisib, a clinical-stage novel oral selective PI3Kδ inhibitor for the treatment of non-hodgkin's lymphoma, in healthy Chinese volunteers 期刊论文  OAI收割 FRONTIERS IN PHARMACOLOGY, 2024, 卷号: 15, 页码: 13 作者:  Zhao, Chun-Yang;  Zhang, Li-Jun;  Sun, Chan;  Yu, Cheng-Yin;  Wang, Jian   |  收藏  |  浏览/下载：18/0  |  提交时间：2025/01/06 amdizalisib  PI3K delta kinase  metabolism  mass balance  metabolite identification  pharmacokinetics  safety   Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3K alpha 期刊论文  OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 卷号: 119, 期号: 46, 页码: 11 作者:  Liu, Xiao;  Zhou, Qingtong;  Hart, Jonathan R.;  Xu, Yingna;  Yang, Su   |  收藏  |  浏览/下载：37/0  |  提交时间：2023/10/17 phosphoinositide 3-kinase (PI3K)  mass spectrometry  mutants   Nanobodies and chemical cross-links advance the structural and functional analysis of PI3K alpha 期刊论文  OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 卷号: 119, 期号: 38, 页码: 9 作者:     |  收藏  |  浏览/下载：36/0  |  提交时间：2023/10/17 phosphoinositide 3-kinase (PI3K)  nanobody  conformational changes  chemical cross-linking  mass spectrometry   Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation 期刊论文  OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 45, 页码: 9 作者:  Liu, Xiao;  Yang, Su;  Hart, Jonathan R.;  Xu, Yingna;  Zou, Xinyu   |  收藏  |  浏览/下载：76/0  |  提交时间：2022/01/04 phosphoinositide 3-kinase (PI3K)  activation  inhibition  activity-dependent conformational changes   Emerging roles of class I PI3K inhibitors in modulating tumor microenvironment and immunity 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 8 作者:  Sun, Pu;  Meng, Ling-hua   |  收藏  |  浏览/下载：39/0  |  提交时间：2020/12/21 phosphoinositide 3-kinase (PI3K)  PI3K inhibitors  tumor microenvironment  immune cells  immunotherapy   Design, synthesis and antiproliferative activity evaluation of a series of pyrrolo [2,1-f] [1,2,4] triazine derivatives 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 12, 页码: 4 作者:  Xiang, Hao-Yue;  Chen, Yan-Hong;  Wang, Yi;  Zhang, Xi;  Ding, Jian   |  收藏  |  浏览/下载：41/0  |  提交时间：2020/07/01 Antiproliferative  Cancer  Therapy  PI3K inhibitors  Pyrrolo [2,1-f][1,2,4] triazine  Kinase   Development of novel chromeno[4,3-c]pyrazol-4(2H)-one derivates containing piperazine as inhibitors of PI3K alpha 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2019, 卷号: 92 作者:  Yin, Yong;  Zhou, Yang;  Sha, Shao;  Wu, Xun;  Wang, She-Feng   |  收藏  |  浏览/下载：41/0  |  提交时间：2019/12/18 EMBRYONIC LETHALITY  PATHWAY  KINASE  PI3K  DISCOVERY  3-KINASES  SUBUNIT  GROWTH  POTENT  TARGET   Development of novel chromeno[4,3-c]pyrazol-4(2H)-one derivates containing piperazine as inhibitors of PI3K alpha 会议论文  OAI收割 作者:  Yin, Yong;  Zhou, Yang;  Sha, Shao;  Wu, Xun   |  收藏  |  浏览/下载：165/0  |  提交时间：2021/12/02 EMBRYONIC LETHALITY  PATHWAY  KINASE  PI3K  DISCOVERY  3-KINASES  SUBUNIT  GROWTH  POTENT  TARGET   High-throughput screening campaigns against a PI3K alpha isoform bearing the H1047R mutation identified potential inhibitors with novel scaffolds 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 11, 页码: 1816-1822 作者:  Wang, Jia;  Gong, Grace Qun;  Zhou, Yan   |  收藏  |  浏览/下载：100/0  |  提交时间：2019/01/08 high throughput screening  PI3 kinase  PI3K alpha H1047R  inhibitors  molecular modeling   Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2018, 卷号: 8, 期号: 5, 页码: 767-771 作者:  Basnet, Rajesh;  Gong, Grace Qun;  Li, Chenyao;  Wang, Ming-Wei   |  收藏  |  浏览/下载：42/0  |  提交时间：2019/01/08 SGK  AKT  PI3K  Cancer  Signalling: Kinase  Inhibitor