机构

• 上海药物研究所 [27]
• 合肥物质科学研究院 [3]

采集方式

• OAI收割 [30]

内容类型

• 期刊论文 [30]

发表日期

• 2024 [11]
• 2023 [4]
• 2022 [8]
• 2021 [6]
• 2020 [1]

学科主题

筛选

浏览/检索结果: 共30条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Discovery of a Potent, selective and orally bioavailable CDK9 degrader for targeting transcription regulation in Triple-Negative breast cancer 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2024, 卷号: 153, 页码: 16 作者:  Nie, Hui-Jun;  Li, Ben-Fu;  Sun, Jingya;  Yuan, Yali;  Zhang, Zhi-Gao   |  收藏  |  浏览/下载：8/0  |  提交时间：2024/11/26 Triple-negative breast cancer  Targeting transcription regulation  Orally bioavailable degrader  PROTAC  Cyclin-dependent Kinase 9   Discovery of a potent PROTAC degrader for RNA demethylase FTO as antileukemic therapy 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 12, 页码: 5382-5392 作者:  Liu, Lu;  Qiu, Yuanlai;  Suo, Yuying;  Tong, Siyao;  Wang, Yiqing   |  收藏  |  浏览/下载：7/0  |  提交时间：2025/04/01 N 6-Methyladenosine  FTO  PROTAC  RNA epigenetics  Antileukemia   Discovery of KW0113 as a First and Effective PROTAC Degrader of DNMT1 Protein 期刊论文  OAI收割 CHEMMEDCHEM, 2024, 页码: 16 作者:  Wang, Huihui;  Wang, Zhaoliang;  Hu, Linghao;  Yang, Bingjie;  Zong, Liangyi   |  收藏  |  浏览/下载：10/0  |  提交时间：2024/12/16 Degrader  DNMT1  DNA methylation  PROTAC   Liver-targeting chimeras as a potential modality for the treatment of liver diseases 期刊论文  OAI收割 JOURNAL OF CONTROLLED RELEASE, 2024, 卷号: 374, 页码: 627-638 作者:  Chen, Chuanjie;  Pan, Yongzhang;  Yang, Xiaoyu;  Li, Huiqin;  Cai, Xinhui   |  收藏  |  浏览/下载：18/0  |  提交时间：2024/10/21 ASGPR  BET  Hepatocellular carcinoma  LIVTAC  On-target toxicity  PROTAC   PROTAC derivatization of natural products for target identification and drug discovery: Design of evodiamine-based PROTACs as novel REXO4 degraders 期刊论文  OAI收割 JOURNAL OF ADVANCED RESEARCH, 2024, 卷号: 63, 页码: 219-230 作者:  Chen, Shuqiang;  Bi, Kaijian;  Liang, Huixin;  Wu, Zhe;  Huang, Min   |  收藏  |  浏览/下载：13/0  |  提交时间：2024/10/21 PROTAC  Natural products  Target identification  Quantitative proteomics  Antitumor activities   Targeting EGFR with molecular degraders as a promising strategy to overcome resistance to EGFR inhibitors 期刊论文  OAI收割 FUTURE MEDICINAL CHEMISTRY, 2024, 页码: 22 作者:  Wang, Qiangfeng;  Zhu, Yumeng;  Pei, Junping   |  收藏  |  浏览/下载：12/0  |  提交时间：2024/10/21 cancer  degrader  EGFR  lysosome-based degradation  PROTAC  resistance   Discovery of PRMT3 Degrader for the Treatment of Acute Leukemia 期刊论文  OAI收割 ADVANCED SCIENCE, 2024, 页码: 8 作者:  Zou, Wanyi;  Li, Mengna;  Wan, Shili;  Ma, Jingkun;  Lian, Linan   |  收藏  |  浏览/下载：8/0  |  提交时间：2024/09/26 acute leukemia  MDM2  oxidative phosphorylation  PRMT3  PROTAC   Design, synthesis, and bioevaluation of SOS1 PROTACs derived from pyrido [2,3- d ]pyrimidin-7-one-based SOS1 inhibitor 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 107, 页码: 9 作者:  Wang, Kun;  Zhou, Zehui;  Ma, Xinyi;  Xu, Jiahang;  Xu, Wangyang   |  收藏  |  浏览/下载：21/0  |  提交时间：2024/07/12 SOS1  KRAS mutation  PROTAC  Anti-cancer activity   An overview of PROTACs targeting MDM2 as a novel approach for cancer therapy 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 272, 页码: 8 作者:  Li, Huiwen;  Cai, Xinhui;  Yang, Xiaoyu;  Zhang, Xuan   |  收藏  |  浏览/下载：21/0  |  提交时间：2024/09/26 MDM2  PROTAC  p53  MDMX  Targeted protein degradation   Design, Synthesis, and Bioevaluation of Transcriptional Enhanced Assocciated Domain (TEAD) PROTAC Degraders 期刊论文  OAI收割 ACS MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 15, 期号: 5, 页码: 631-639 作者:  Li, Huajie;  Ge, Zhiming;  Lin, Kexin;  He, Wei;  Chu, Qinyu   |  收藏  |  浏览/下载：39/0  |  提交时间：2024/06/27 Hippo pathway  TEAD  PROTAC  Selectivity