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• 上海药物研究所 [302]
• 金属研究所 [15]
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• OAI收割 [376]
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发表日期

• 2025 [7]
• 2024 [11]
• 2023 [9]
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学科主题

• Chemistry [16]
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浏览/检索结果: 共385条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序作者升序作者降序 Pharmacokinetics and Safety of TPN171 (a PDE5 Inhibitor) in Patients With Mild or Moderate Hepatic Impairment Versus Participants With Normal Hepatic Function: A Phase I Study 期刊论文  OAI收割 CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2025, 页码: 7 作者:  Zhou, Jing;  Zhang, Hong;  Ding, Yanhua;  Wang, Zhen;  Wang, Yu   |  收藏  |  浏览/下载：0/0  |  提交时间：2025/06/23 hepatic impairment  pharmacokinetics  phosphodiesterase-5 inhibitor  TPN171   A Phase I Study to Evaluate the Pharmacokinetics and Safety of TPN171 (a PDE5 Inhibitor) in Adults with Renal Impairment 期刊论文  OAI收割 CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2025, 页码: 8 作者:  Fu, Ping;  Song, Yi;  Hu, Chao;  Yong, Xiaolan;  Yu, Yang   |  收藏  |  浏览/下载：1/0  |  提交时间：2025/06/23 pharmacokinetics  phosphodiesterase 5 inhibitor  renal impairment  safety  TPN171   Hemodynamic and Pharmacokinetic Interactions of TPN171 with Alcohol in Healthy Male Subjects 期刊论文  OAI收割 CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2025, 卷号: 18, 期号: 2, 页码: 8 作者:  Cheng, Jie;  Qian, Hongjie;  Wang, Yu;  Liang, Liyu;  Xu, Wenjing   |  收藏  |  浏览/下载：6/0  |  提交时间：2025/04/01 alcohol  healthy subjects  hemodynamics  PDE5 inhibitor  pharmacokinetics  TPN171   Exploratory research on the effective chemical basis of tanreqing injection for treating acute lung injury: In vivo, in vitro and in silico 期刊论文  OAI收割 JOURNAL OF ETHNOPHARMACOLOGY, 2025, 卷号: 337, 页码: 11 作者:  Tang, Bixi;  Xie, Like;  Wang, Yangyang;  Shi, Yulong;  Kan, Weijuan   |  收藏  |  浏览/下载：17/0  |  提交时间：2024/11/26 Lung first-pass effect  Tanreqing injection  Pharmacokinetics  Sepsis-associated acute lung injury  Acute respiratory distress syndrome   Quantification of crisugabalin (HSK16149) in biological matrix by LC-MS/ MS method: An application to rat pharmacokinetic and tissue distribution studies 期刊论文  OAI收割 JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2025, 卷号: 1251, 页码: 9 作者:  Wang, Zeyu;  Tang, Pingming;  Dou, Caixia;  Shen, Jiale;  Peng, Ni   |  收藏  |  浏览/下载：9/0  |  提交时间：2025/04/01 Crisugabalin (HSK16149)  LC-MS/MS  Pharmacokinetics  Tissue distribution   Design, synthesis and pharmacological evaluation of 1,2,3,4-tetrahydrobenzofuro[2,3-c] pyridine derivatives as p21-activated kinase 4 inhibitors for treatment of pancreatic cancer 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 1, 页码: 438-466 作者:  Li, Yang;  Fang, Yan;  Chen, Xiaoyu;  Tong, Linjiang;  Feng, Fang   |  收藏  |  浏览/下载：15/0  |  提交时间：2025/04/01 P21-activated kinase 4  Tetrahydrobenzofuro[2  3-c]pyridine  Structure-activity relationship  Allosteric inhibitor  Pharmacokinetics properties  Kinase selectivity  Pancreatic cancer  Immune infiltration   A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics of BGT-002, a Novel ATP-Citrate Lyase Inhibitor, in Healthy Chinese Subjects 期刊论文  OAI收割 DRUG DESIGN DEVELOPMENT AND THERAPY, 2025, 卷号: 19, 页码: 1783-1794 作者:  Liu, Yun;  Yu, Chengyin;  Zhang, Yifan;  Xie, Zhifu;  Wang, Yating   |  收藏  |  浏览/下载：2/0  |  提交时间：2025/04/24 safety  tolerability  pharmacokinetics  pharmacodynamics  BGT-002  novel ACLY inhibitor   Shape and Size Dependence of Pharmacokinetics, Biodistribution, and Toxicity of Gold Nanoparticles 期刊论文  OAI收割 MOLECULAR PHARMACEUTICS, 2024, 页码: 13 作者:  Wu, Huaping;  Tang, Lin;  Dong, Huanhuan;  Zhi, Maoxin;  Guo, Liqiong   |  收藏  |  浏览/下载：7/0  |  提交时间：2025/01/06 gold nanoparticles  nanoparticle morphology  toxicity assessment  biodistribution  pharmacokinetics   Analysis of Herbal Constituents and In Vivo Pharmacokinetics of Gegen-Huangqi Decoction in Rat Plasma Using HPLC-Q-TOF-MS/MS and HPLC-QQQ-MS/MS 期刊论文  OAI收割 BIOMEDICAL CHROMATOGRAPHY, 2024, 页码: 16 作者:  Xu, Zhou;  Wang, Linwei;  Liu, Huan;  Tian, Xiaoting;  Wang, Yangyang   |  收藏  |  浏览/下载：12/0  |  提交时间：2024/12/25 gegen-huangqi decoction  hepatic disposition  LC-MS/MS  pharmacokinetics  qualitative   Mass balance, metabolism, and pharmacokinetics of [14C]amdizalisib, a clinical-stage novel oral selective PI3Kδ inhibitor for the treatment of non-hodgkin's lymphoma, in healthy Chinese volunteers 期刊论文  OAI收割 FRONTIERS IN PHARMACOLOGY, 2024, 卷号: 15, 页码: 13 作者:  Zhao, Chun-Yang;  Zhang, Li-Jun;  Sun, Chan;  Yu, Cheng-Yin;  Wang, Jian   |  收藏  |  浏览/下载：11/0  |  提交时间：2025/01/06 amdizalisib  PI3K delta kinase  metabolism  mass balance  metabolite identification  pharmacokinetics  safety