中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [299]
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题名升序
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Hemodynamic and Pharmacokinetic Interactions of TPN171 with Alcohol in Healthy Male Subjects
期刊论文
OAI收割
CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2025, 卷号: 18, 期号: 2, 页码: 8
作者:
Cheng, Jie
;
Qian, Hongjie
;
Wang, Yu
;
Liang, Liyu
;
Xu, Wenjing
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/04/01
alcohol
healthy subjects
hemodynamics
PDE5 inhibitor
pharmacokinetics
TPN171
Exploratory research on the effective chemical basis of tanreqing injection for treating acute lung injury: In vivo, in vitro and in silico
期刊论文
OAI收割
JOURNAL OF ETHNOPHARMACOLOGY, 2025, 卷号: 337, 页码: 11
作者:
Tang, Bixi
;
Xie, Like
;
Wang, Yangyang
;
Shi, Yulong
;
Kan, Weijuan
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/11/26
Lung first-pass effect
Tanreqing injection
Pharmacokinetics
Sepsis-associated acute lung injury
Acute respiratory distress syndrome
Quantification of crisugabalin (HSK16149) in biological matrix by LC-MS/ MS method: An application to rat pharmacokinetic and tissue distribution studies
期刊论文
OAI收割
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2025, 卷号: 1251, 页码: 9
作者:
Wang, Zeyu
;
Tang, Pingming
;
Dou, Caixia
;
Shen, Jiale
;
Peng, Ni
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/04/01
Crisugabalin (HSK16149)
LC-MS/MS
Pharmacokinetics
Tissue distribution
Design, synthesis and pharmacological evaluation of 1,2,3,4-tetrahydrobenzofuro[2,3-c] pyridine derivatives as p21-activated kinase 4 inhibitors for treatment of pancreatic cancer
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 1, 页码: 438-466
作者:
Li, Yang
;
Fang, Yan
;
Chen, Xiaoyu
;
Tong, Linjiang
;
Feng, Fang
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2025/04/01
P21-activated kinase 4
Tetrahydrobenzofuro[2
3-c]pyridine
Structure-activity relationship
Allosteric inhibitor
Pharmacokinetics properties
Kinase selectivity
Pancreatic cancer
Immune infiltration
Shape and Size Dependence of Pharmacokinetics, Biodistribution, and Toxicity of Gold Nanoparticles
期刊论文
OAI收割
MOLECULAR PHARMACEUTICS, 2024, 页码: 13
作者:
Wu, Huaping
;
Tang, Lin
;
Dong, Huanhuan
;
Zhi, Maoxin
;
Guo, Liqiong
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/01/06
gold nanoparticles
nanoparticle morphology
toxicity assessment
biodistribution
pharmacokinetics
Analysis of Herbal Constituents and In Vivo Pharmacokinetics of
Gegen-Huangqi
Decoction in Rat Plasma Using HPLC-Q-TOF-MS/MS and HPLC-QQQ-MS/MS
期刊论文
OAI收割
BIOMEDICAL CHROMATOGRAPHY, 2024, 页码: 16
作者:
Xu, Zhou
;
Wang, Linwei
;
Liu, Huan
;
Tian, Xiaoting
;
Wang, Yangyang
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/12/25
gegen-huangqi
decoction
hepatic disposition
LC-MS/MS
pharmacokinetics
qualitative
Mass balance, metabolism, and pharmacokinetics of [
14
C]amdizalisib, a clinical-stage novel oral selective PI3Kδ inhibitor for the treatment of non-hodgkin's lymphoma, in healthy Chinese volunteers
期刊论文
OAI收割
FRONTIERS IN PHARMACOLOGY, 2024, 卷号: 15, 页码: 13
作者:
Zhao, Chun-Yang
;
Zhang, Li-Jun
;
Sun, Chan
;
Yu, Cheng-Yin
;
Wang, Jian
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/01/06
amdizalisib
PI3K delta kinase
metabolism
mass balance
metabolite identification
pharmacokinetics
safety
19
F qNMR based pharmacokinetics, metabolism and mass balance studies of SARS-CoV-2-3CL protease inhibitor simnotrelvir (SIM0417) in humans
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 11
作者:
Wang, Ze-yu
;
Ren, Yong-mei
;
Hu, Shu-wei
;
Zhang, Nai-xia
;
Dong, Meng-xiao
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2024/11/05
COVID-19
simnotrelvir
F-19 qNMR
pharmacokinetics
metabolism
mass balance.
Development of an ELISA with acidification treatment for an antibody conjugate incorporating Exatecans
期刊论文
OAI收割
ANALYTICAL BIOCHEMISTRY, 2024, 卷号: 690, 页码: 8
作者:
Zhang, Yingying
;
Yun, Xi
;
Ouyang, Lu
;
Zhang, Xianjing
;
Gong, Likum
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2024/06/27
Antibody-drug conjugate
Camptothecin
Exatecan
Bioanalysis
Pharmacokinetics
A validated LC-MS/MS method for the quantitation of daratumumab in rat serum using rapid tryptic digestion without IgG purification and reduction
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2024, 卷号: 243, 页码: 8
作者:
Li, Weiqiang
;
Huang, Wensi
;
Yu, Xiong
;
Chen, Chong
;
Yuan, Yali
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2024/05/22
Daratumumab
LC-MS/MS
Surrogate peptide
Pharmacokinetics