机构

• 上海药物研究所 [5]
• 新疆理化技术研究所 [1]

采集方式

• OAI收割 [6]

内容类型

• 期刊论文 [6]

发表日期

• 2023 [1]
• 2022 [1]
• 2020 [1]
• 2019 [3]

学科主题

筛选

浏览/检索结果: 共6条，第1-6条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Pharmacokinetics,mass balance,and metabolism of 14C TPN171,a novel PDE5 inhibitor,in humans for the treatment of pulmonary arterial hypertension 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 卷号: 44, 期号: 1, 页码: 221 作者:  He Yifei;  Liu Yin;  Yu Jinghua;  Cheng Huan;  Odilov Abdullajon   |  收藏  |  浏览/下载：15/0  |  提交时间：2023/05/22 TPN171  14CTPN171  PDE5 inhibitor  pulmonary arterial hypertension  healthy volunteers  pharmacokinetics  metabolite identification  mass balance   Pharmacokinetics, mass balance, and metabolism of [C-14]TPN171, a novel PDE5 inhibitor, in humans for the treatment of pulmonary arterial hypertension 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2022, 页码: 13 作者:  He, Yi-fei   |  收藏  |  浏览/下载：31/0  |  提交时间：2022/08/16 TPN171  [C-14]TPN171  PDE5 inhibitor  pulmonary arterial hypertension  healthy volunteers  pharmacokinetics  metabolite identification  mass balance   Liquid chromatography-tandem mass spectrometric assay for TPN171 in human plasma 期刊论文  OAI收割 JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2020, 卷号: 191, 页码: 8 作者:  Zhang, Mengqi;  Liu, Haiming;  He, Jiajin;  Gui, Yuzhou;  Qian, Hongjie   |  收藏  |  浏览/下载：37/0  |  提交时间：2020/12/24 TPN171  LC-MS/MS  Human plasma  Protein precipitation   Characterization of TPN171 metabolism in humans via ultra-performance liquid chromatography/quadrupole time-of-flight Checir for mass spectrometry 期刊论文  OAI收割 JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2019, 卷号: 172, 页码: 302-310 作者:  Pan, Lulu;  Guo, Shuang;  Chen, Xiaoyan;  Jiang, Xiangrui;  Shen, Jingshan   |  收藏  |  浏览/下载：29/0  |  提交时间：2020/07/01 TPNI71  Metabolism  UPLC/Q-TOF MS  High-resolution mass spectrometry  Metabolite identification   Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990 作者:     |  收藏  |  浏览/下载：37/0  |  提交时间：2020/07/01 Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990 作者:  Wang, Z (Wang, Zhen)[ 1 ];  Jiang, XR (Jiang, Xiangrui)[ 1 ];  Zhang, XL (Zhang, Xianglei)[ 1,2 ];  Tian, GH (Tian, Guanghui)[ 3 ];  Yang, RL (Yang, Rulei)[ 3 ]   |  收藏  |  浏览/下载：133/0  |  提交时间：2019/06/28