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Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [85]
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Pharmacological characterizationof tachykinin tetrabranched derivatives
期刊论文
OAI收割
出版物, 3111, 期号: 0, 页码: 1-36
作者:
Chiara Ruzza
;
Anna Rizzi
;
Davide Malfacini
;
Maria Camilla Cerlesi
;
Federica Ferrari
  |  
收藏
  |  
浏览/下载:197/0
  |  
提交时间:2017/07/24
Tachykinins
Substance p
Pwt2-sp
Nk1 Receptor
Calcium Mobilization
Bioluminescence Resonance Energy Transfer
Guinea Pig Ileum
Rat Urinary Bladder
Nociceptive Behaviour Induced By Spinal Substance p
Mice
The Tyrosine Kinase Inhibitor Bafetinib Inhibits PAR2-induced Activation of TRPV4 In Vitro and Pain In Vivo1
期刊论文
OAI收割
出版物, 2111, 页码: 1-44
作者:
1M S Grace
;
T Lieu
;
B Darby
;
F C Abogadie
;
N Veldhuis N W Bunnett
;
P McIntyre
  |  
收藏
  |  
浏览/下载:244/0
  |  
提交时间:2017/07/24
Transient Receptor Potential Ion Channel
Trpv4
Protease Activated Receptor
Par2
Pain
Tyrosine Kinase
Bafetinib
Molecular basis of lipid and ligand regulation of prostaglandin receptor DP2
期刊论文
OAI收割
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2024, 卷号: 121, 期号: 51, 页码: 12
作者:
Xu, Jiuyin
;
Xu, Youwei
;
Hou, Li
;
He, Xinheng
;
Li, Yang
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2025/02/28
prostaglandin receptor
DP2
lipid regulation
receptor activation
signal bias
Pyrotinib plus capecitabine for patients with HER2-positive metastatic breast cancer and brain metastases (PERMEATE trial): overall survival results from a multicenter, single-arm, two-cohort, phase 2 trial
期刊论文
OAI收割
ECLINICALMEDICINE, 2024, 卷号: 76
作者:
Yan, Min
;
Ouyang, Quchang
;
Sun, Tao
;
Niu, Limin
;
Yang, Jin
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/11/20
Pyrotinib
Human epidermal growth factor receptor 2
Breast cancer
Brain metastases
Overall survival
The antidepressant-like effect and proposed mechanism of action of TPN672MA, a novel serotonin-dopamine receptor modulator for the treatment of schizophrenia
期刊论文
OAI收割
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2024, 卷号: 242, 页码: 13
作者:
Cheng, Jiaxin
;
Wu, Chunhui
;
Wang, Yu
;
Wang, Zhen
;
He, Yang
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/09/24
TPN672MA
5-HT 1A receptor agonist
D 2 /D 3 receptor partial agonist
5-HT 2A receptor antagonist
Antidepressant-like
Mechanism
Targeting CCL2-CCR2 signaling pathway alleviates macrophage dysfunction in COPD via PI3K-AKT axis
期刊论文
OAI收割
CELL COMMUNICATION AND SIGNALING, 2024, 卷号: 22, 期号: 1, 页码: 19
作者:
Dong, Yue
;
Dong, Ying
;
Zhu, Chengyue
;
Yang, Lan
;
Wang, Hanlin
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收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/08/22
Chronic obstructive pulmonary disease
C-C motif chemokine ligand 2
C-C chemokine receptor type 2
Bronchial epithelial cells
Macrophage
Nanobodies as negative allosteric modulators for human calcium sensing receptor
期刊论文
OAI收割
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2024, 卷号: 695, 页码: 9
作者:
Cui, Qianqian
;
Wang, Lu
;
Wang, Haonan
;
Chen, Xiaochen
;
Han, Li
  |  
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2024/04/09
G-protein-coupled receptor
Extracellular calcium sensing receptor
Nanobody
Cryo-electron microscope
Systemic Ca 2+homoeostasis
Synthesis, evaluation and molecular dynamics study of human toll-like receptor 2/6 specific monoacyl lipopeptides as candidate immunostimulants
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 141, 页码: 17
作者:
Zhu, Yueyue
;
Liu, Bo
;
Chen, Zonglong
;
Wang, Xianyang
;
Wang, Yujie
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2023/12/08
Toll -like receptor 2/6 agonists
PamCS
Structure-activity relationship
Lipopeptide
Immunostimulants
Discovery of Potent and Selective CB2 Agonists Utilizing a Function-Based Computational Screening Protocol
期刊论文
OAI收割
ACS CHEMICAL NEUROSCIENCE, 2023, 卷号: 14, 期号: 21, 页码: 3941-3958
作者:
Ge, Haixia
;
Ji, Beihong
;
Fang, Jiahui
;
Wang, Jiayang
;
Li, Jing
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2023/12/11
function-based ligand design
receptor-ligandbinding profile
CB1/CB2
structure-activityrelationship
Structure basis of two nanobodies neutralizing SARS-CoV-2 Omicron variant by targeting ultra-conservative epitopes
期刊论文
OAI收割
JOURNAL OF STRUCTURAL BIOLOGY, 2023, 卷号: 215, 期号: 3, 页码: 9
作者:
Sun, Zengchao
;
Wang, Lu
;
Li, Lingyun
;
Sun, Yili
;
Zhang, Daizhou
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2023/10/17
SARS-CoV-2 virus
Receptor -binding domain
Nanobody
Crystal structure
Conservative binding epitope
Bi-paratopic nanobodies