中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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The Tyrosine Kinase Inhibitor Bafetinib Inhibits PAR2-induced Activation of TRPV4 In Vitro and Pain In Vivo1
期刊论文
OAI收割
出版物, 2111, 页码: 1-44
作者:
1M S Grace
;
T Lieu
;
B Darby
;
F C Abogadie
;
N Veldhuis N W Bunnett
;
P McIntyre
  |  
收藏
  |  
浏览/下载:220/0
  |  
提交时间:2017/07/24
Transient Receptor Potential Ion Channel
Trpv4
Protease Activated Receptor
Par2
Pain
Tyrosine Kinase
Bafetinib
Discovery of a 1,6-naphthyridin-4-one-based AXL inhibitor with improved pharmacokinetics and enhanced in vivo antitumor efficacy
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 17
作者:
Lan, Yaohan
;
Peng, Xia
;
Ji, Yinchun
;
Su, Yi
;
Duan, Wenhu
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/02/27
AXL inhibitor
In vivo antitumor efficacy
6-Naphthyridin-4-one derivatives
Scaffold hopping
Structure-based drug design
Discovery of a potent and selective covalent threonine tyrosine kinase (TTK) inhibitor
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 143, 页码: 16
作者:
Sun, Yaoliang
;
Chen, Zhiwen
;
Liu, Guobin
;
Chen, Xiaoai
;
Shi, Zihan
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/03/25
Inhibitor
Cancer
Threonine tyrosine kinase (TTK)
Covalent
Structure-based drug discovery of novel fused- pyrazolone carboxamide derivatives as potent and selective AXL inhibitors
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4918-4933
作者:
Fang, Feifei
;
Dai, Yang
;
Wang, Hao
;
Ji, Yinchun
;
Liang, Xuewu
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/01/26
derivatives
Antitumor drug development
Potential AXL inhibitor
Antitumor activity
Structure-based drug design
Fused-pyrazolone carboxamide
Design, synthesis and biological evaluation of 2-aminopyrimidine derivatives as potent FLT3 inhibitors
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023, 卷号: 96, 页码: 5
作者:
Lian, Xuanmin
;
Gao, Yue
;
Li, Xuemei
;
Wang, Peipei
;
Tong, Lexian
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2023/12/11
2-aminopyrimidine
FLT3 inhibitors
MV4-11
FLT3 mutations
Comparative proteomic and phosphoproteomic analysis reveals differential heat response mechanism in two congeneric oyster species
期刊论文
OAI收割
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2023, 卷号: 263, 页码: 19
作者:
Wang, Chaogang
;
Du, Mingyang
;
Jiang, Zhuxiang
;
Cong, Rihao
;
Wang, Wei
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2023/12/13
Heat stress
Oysters
Crassostrea angulata
Crassostrea gigas
Phosphorylation
A neural cell adhesion molecule from oyster Crassostrea gigas: Molecular identification and immune functional characterization
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2023, 卷号: 247, 页码: 13
作者:
Qiao, Xue
;
Liu, Conghui
;
Wang, Weilin
;
Yang, Chuanyan
;
Li, Meijia
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2023/12/13
IgCAM
Neural cell adhesion molecule
PRR
Phagocytosis
Design, synthesis and pharmacological evaluation of 2,3-dihydrobenzo-furan IRAK4 inhibitors for the treatment of diffuse large B-cell lymphoma
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 256, 页码: 16
作者:
Chen, Yun
;
Ning, Yi
;
Chen, Zhiwei
;
Xue, Yaping
;
Wu, Qingyun
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2023/10/17
Apoptosis
Diffuse large B-Cell lymphoma
Interleukin-1 receptor associated kinase 4
Structure-based drug design
2
3-Dihydrobenzofuran
Pharmaco-proteogenomic characterization of liver cancer organoids for precision oncology
期刊论文
OAI收割
SCIENCE TRANSLATIONAL MEDICINE, 2023, 卷号: 15, 期号: 706, 页码: 15
作者:
Ji, Shuyi
;
Feng, Li
;
Fu, Zile
;
Wu, Gaohua
;
Wu, Yingcheng
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2023/10/17
ARID3a from the ARID family: structure, role in autoimmune diseases and drug discovery
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 页码: 12
作者:
Guo, Cheng-cen
;
Xu, H. Eric
;
Ma, Xiong
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2023/10/17
transcription factors
ARID
ARID3a
autoimmune diseases
systemic lupus erythematosus
primary biliary cholangitis