中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
机构
采集方式
内容类型
发表日期
学科主题
筛选

浏览/检索结果: 共7条，第1-7条 帮助

条数/页： 排序方式：
NF-kappa B and JNK mediated apoptosis and G(0)/G(1) arrest of HeLa cells induced by rubiarbonol G, an arborinane-type triterpenoid from Rubia yunnanensis 期刊论文  OAI收割
JOURNAL OF ETHNOPHARMACOLOGY, 2018, 卷号: 220, 页码: 220-227
作者:  Zeng, Guang-Zhi;  Wang, Zhe;  Zhao, Li-Mei;  Fan, Jun-Ting;  Tan, Ning-Hua
  |  收藏  |  浏览/下载：29/0  |  提交时间：2018/07/16
Stereochemical assignments of rubiaquinones A-C, naphthoquinone derivatives from &ITRubia yunnanensis&IT 期刊论文  OAI收割
TETRAHEDRON LETTERS, 2017, 卷号: 58, 期号: 48, 页码: 4568-4571
作者:  Suyama, Yoshihiro;  Higashino, Yusuke;  Tanaka, Naonobu;  Tatano, Yutaka;  Yagi, Hideki
  |  收藏  |  浏览/下载：27/0  |  提交时间：2018/05/08
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文  OAI收割
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
收藏  |  浏览/下载：41/0  |  提交时间：2015/05/14
2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA)  one of the major components isolated from the traditional  Chinese medicine Rubia yunnanensis  exhibited inhibitory activity on the proliferation of several  human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay  and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle  arrest in human cervical carcinoma HeLa cells. Further  MTA was found to induce apoptosis of HeLa cells  through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and  release of cytochrome c into the cytosol  which caused the cleavage of caspase and poly(ADP-ribose)  polymerase and finally triggered the apoptosis. Furthermore  the p53/p21/Cdc2-cyclin B1 signaling was  found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of  cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused  the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of  R. yunnanensis  a folk anti-cancer herb used in Yunnan  China.  
Cyclopeptide RA-V inhibits angiogenesis by down-regulating ERK1/2 phosphorylation in HUVEC and HMEC-1 endothelial cells 期刊论文  OAI收割
BRITISH JOURNAL OF PHARMACOLOGY, 2011, 卷号: 164, 期号: 7, 页码: 1883-1898
作者:  Yue, Grace G. L.;  Fan, Jun-Ting;  Lee, Julia K. M.;  Zeng, Guang-Zhi;  Ho, Tina W. F.
  |  收藏  |  浏览/下载：28/0  |  提交时间：2012/07/25
Rubiyunnanins A and B, two novel cyclic hexapeptides from Rubia yunnanensis 期刊论文  OAI收割
TETRAHEDRON LETTERS, 2010, 卷号: 51, 期号: 52, 页码: 6810-6813
作者:  Fan, Jun-Ting;  Chen, Yi-Shan;  Xu, Wen-Yan;  Du, Liangcheng;  Zeng, Guang-Zhi
  |  收藏  |  浏览/下载：19/0  |  提交时间：2012/03/21
Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-kappa B activation 期刊论文  OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 卷号: 18, 期号: 23, 页码: 8226-8234
作者:  Fan, Jun-Ting;  Su, Jia;  Peng, Yan-Min;  Li, Yan;  Li, Jia
  |  收藏  |  浏览/下载：23/0  |  提交时间：2012/03/21
Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-kappa B activation 期刊论文  OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 卷号: 18, 期号: 23, 页码: 8226-8234
作者:  Fan, Jun-Ting;  Su, Jia;  Peng, Yan-Min;  Li, Yan;  Li, Jia
  |  收藏  |  浏览/下载：18/0  |  提交时间：2019/01/08