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Circular Bispecific Aptamer-Mediated Artificial Intercellular Recognition for Targeted T Cell Immunotherapy
期刊论文
OAI收割
ACS NANO, 2020, 卷号: 14
作者:
Yang, Yu
;
Sun, Xiaoqi
;
Xu, Jun
;
Cui, Cheng
;
Yazd, Hoda Safari
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收藏
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浏览/下载:38/0
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提交时间:2020/10/26
recognition-then-activation
circular bispecific aptamer
cb-aptamer
adoptive T cell immunotherapy
T cell immunotherapy
on shelf
Introducing a special collection of papers in the Journal of High Energy Astrophysics on the Early Results of China's 1st X-ray Astronomy Satellite: Insight-HXMT
期刊论文
OAI收割
Journal of High Energy Astrophysics, 2020, 卷号: 27, 页码: 51-52
作者:
HXMT
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收藏
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浏览/下载:55/0
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提交时间:2022/02/08
Astrophysics - High Energy Astrophysical Phenomena
Abstract: Insight-HXMT is the first Chinese X-ray astronomical mission, launched successfully on June 15, 2017, from China's Jiuquan Satellite Launch Center. Insight-HXMT was designed to have a broad energy coverage in X-rays, from 1-250 keV, with excellent timing and adequate energy resolution at soft X-rays, and the largest effective area at hard X-rays. This allows, in particular, to observe bright sources like X-ray binaries (XRBs) in their bright/outburst states with high cadence and high statistics at hard and soft X-rays at once. It was then expected that the Insight-HXMT mission will bring us new insights regarding the characteristics of several source classes. Examples include characterizing High-Mass X-ray Binaries (HMXBs) and the outburst evolution of Low-Mass X-ray Binaries (LMXBs). For instance, in HMXB systems, the region around their Alfven radius that is responsible to determine whether accretion or propeller occurs, or the region around the NS magnetic pole where the intense X-rays are supposed to be produced are specially appealing targets of study. For the LMXBs, the evolution the outburst and the properties of the compact objects themselves are obvious priority targets for Insight-HXMT. Due to the broad coverage in energy, Insight-HXMT is specially well suited to study the influence of thermonuclear (type-I) X-ray bursts upon the surrounding environment.
The braking index of PSR B0540-69 and the associated pulsar wind nebula emission after spin-down rate transition
期刊论文
OAI收割
Monthly Notices of the Royal Astronomical Society, 2020, 卷号: 494, 页码: 1865-1870
作者:
HXMT
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收藏
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浏览/下载:66/0
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提交时间:2022/02/08
stars: magnetic field
stars: neutron
pulsars: general
Astrophysics
- High Energy Astrophysical Phenomena
Abstract: In 2011 December, PSR B054-69 experienced a spin-down rate transition (SRT), after which the spin-down power of the pulsar increased by $\sim 36{{\ \rm per\ cent}}$. About 1000 d after the SRT, the X-ray luminosity of the associated pulsar wind nebula (PWN) was found to brighten by $32\pm 8{{\ \rm per\ cent}}$. After the SRT, the braking index n of PSR B0540-69 changes from n = 2.12 to 0.03 and then keeps this value for about five years before rising to n = 0.9 in the following years. We find that most of the current models have difficulties in explaining the measured braking index. One exceptive model of the braking index evolution is the increasing dipole magnetic field of PSR B0540-69. We suggest that the field increase may result from some instabilities within the pulsar core that enhance the poloidal component at the price of toroidal component of the magnetic field. The increasing dipole magnetic field will result in the X-ray brightening of the PWN. We fit the PWN X-ray light curve by two models: one assumes a constant magnetic field within the PWN during the brightening and the other assumes an enhanced magnetic field proportional to the energy density of the PWN. It appears that the two models fit the data well, though the later model seems to fit the data a bit better. This provides marginal observational evidence that magnetic field in the PWN is generated by the termination shock. Future high-quality and high-cadence data are required to draw a solid conclusion.
食用蔬菜能吸收和积累微塑料
期刊论文
OAI收割
科学通报, 2019, 卷号: 64, 期号: 9, 页码: 928-934
作者:
李连祯
;
周倩
;
尹娜
;
涂晨
;
骆永明
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收藏
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浏览/下载:149/0
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提交时间:2020/06/17
微塑料
生菜
聚苯乙烯微球
吸收
积累
健康风险
microplastics
lettuce
polystyrene microbeads
uptake
accumulation
human health risk
Microplastic (MP, 100 nm-5 mm) may present an attributable risk to ecosystem and human health, and its pollution has become a global environmental concern. Despite a wealth of information on the accumulation of MPs in aquatic species, there is no information on the uptake and accumulation of MPs by higher plants. Terrestrial edible plants are directly exposed to MPs when agricultural soil was applied with organic manure, sewage sludge as fertilizer or plastic mulching. In this paper, the uptake of two sizes of polystyrene (PS) microbeads (0.2 and 1.0 mum) and then their distribution and migration in an edible plant lettuce were firstly investigated based on laboratory experiments. We used fluorescent markers to track PS microbeads in plant tissues and found fluorescence to be a sensitive and reliable detection method. Sections from untreated control lettuce showed no autofluorescence. When roots were treated with fluorescently labeled PS microbeads, the microbeads could be identified by its fluorescence. Our main study investigated the uptake of 0.2 mum beads, as few luminescence signals were observed in lettuce roots for 1.0 mum beads in our experiment. We observed that 0.2 mum fluorescent microbeads were extracellularly trapped in the root cap mucilage (which is a highly hydrated polysaccharide) and a dark green tip (which was typical of lettuce roots exposed to label PS beads) was usually visible to the naked eye. Confocal images revealed that the PS luminescence signals were mainly located in the vascular system and on the cell walls of the cortex tissue of the roots, indicated that the beads passed through the intercellular space via the apoplastic transport system. Once inside the central cylinder, the 0.2 mum PS beads were transferred from the roots to the stems and leaves via the vascular system following the transpiration stream. We also observed that the PS beads adhered to one another and self-assembled systematically into grape-like and (chain) string-like clusters in the intercellular space of the root and stem vascular tissue of lettuce plant. In contrast to the root and stem, PS beads were dispersed in the leaf tissue. Here, for the first time we provide evidence of the adherence, uptake, accumulation, and translocation of submicrometer MPs within an edible plant. Our findings highlight the previously underappreciated human exposure pathway to MPs through the consumption of contaminated crops and emphasize the need for new management strategies to control the release of MPs waste products into the terrestrial environment. Ultimately, the potential impacts of low range sized MPs on food safety of crop plants and human health need to be urgently considered.
Utility-Based Resource Allocation in Wireless-Powered Communication Networks
期刊论文
OAI收割
IEEE Systems Journal, 2018, 页码: 1-4
作者:
Zheng M(郑萌)
;
Yu HB(于海斌)
;
Liang W(梁炜)
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收藏
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浏览/下载:30/0
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提交时间:2018/04/01
Harvest-then-transmit
radio frequency (RF) energy harvesting
utility
wireless-powered communication network (WPCN)
Structural design and simulation analysis of ejector used in automotive power steering oil discharge equipment (EI CONFERENCE)
会议论文
OAI收割
2012 International Conference on Mechanical Engineering, Materials Science and Civil Engineering, ICMEMSCE 2012, August 18, 2012 - August 20, 2012, Harbin, China
Cheng K.
;
Zou H.
;
Kong X.
;
Tang J.
收藏
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浏览/下载:28/0
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提交时间:2013/03/25
The structure of ejector used in automotive power steering oil discharge equipment is designed in accordance with the theory of gas-liquid ejector.The two important parameters of the ejector are elected respectively to five values and then 25 ejector models are obtained by the permutations and combinations.The ejector's CFD model is created by Fluent module of Ansys
then it is divided into a grid and analyzed. Analyse its pressure distribution and velocity vector
which provides the optimal size for the manufacture of the ejectors and a theoretical basis for experiment. (2013) Trans Tech Publications
Switzerland.
Data normalization of single camera visual measurement network system (EI CONFERENCE)
会议论文
OAI收割
2012 International Conference on Information Technology and Management Innovation, ICITMI 2012, November 10, 2012 - November 11, 2012, Guangzhou, China
作者:
Zhang Y.-C.
;
Zhou J.
收藏
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浏览/下载:26/0
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提交时间:2013/03/25
With the development of visual measurement system
Normalize the measured coordinates into the same world coordinate system
Apply in the three coordinate measuring machine(CMM) to have the simulation experiment
So the data normalization has the advantage of more high precision. (2013) Trans Tech Publications
the visual measurement system of single camera which applied in the imaging theory of optical feature points
then get the global data
the result indicates that the maximum absolute tolerance between the normalization coordinates via the center of point set and the ones measured by CMM directly is 0.058mm
Switzerland.
it has been widespread used in the modern production. Due to the limit of the environment in scene
and achieve the overall measurement
the visual measurement system of single camera could not measure the shield between the measured objects each other. Focus on this problem
But the one between the coordinate repeatedly measured at the position of one network control point is 0.066mm
present a kind of the the knowledge of measurement network based on the visual measurement of single camera
set up the measurement network system via the multi-control points. Measure the optical feature points in every network control point via the visual measurement system of single camera
Advanced astigmatism-corrected tandem Wadsworth mounting for small-scale spectral broadband imaging spectrometer (EI CONFERENCE)
会议论文
OAI收割
作者:
Lin G.-Y.
收藏
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浏览/下载:40/0
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提交时间:2013/03/25
Tandem gratings of double-dispersion mount make it possible to design an imaging spectrometer for the weak light observation with high spatial resolution
high spectral resolution
and high optical transmission efficiency. The traditional tandem Wadsworth mounting is originally designed to match the coaxial telescope and large-scale imaging spectrometer. When it is used to connect the off-axis telescope such as off-axis parabolic mirror
it presents lower imaging quality than to connect the coaxial telescope. It may also introduce interference among the detector and the optical elements as it is applied to the short focal length and small-scale spectrometer in a close volume by satellite. An advanced tandem Wadsworth mounting has been investigated to deal with the situation. The Wadsworth astigmatism-corrected mounting condition for which is expressed as the distance between the second concave grating and the imaging plane is calculated. Then the optimum arrangement for the first plane grating and the second concave grating
which make the anterior Wadsworth condition fulfilling each wavelength
is analyzed by the geometric and first order differential calculation. These two arrangements comprise the advanced Wadsworth mounting condition. The spectral resolution has also been calculated by these conditions. An example designed by the optimum theory proves that the advanced tandem Wadsworth mounting performs excellently in spectral broadband. 2012 Optical Society of America.
A line mapping based automatic registration algorithm of infrared and visible images
会议论文
OAI收割
5th International Symposium on Photoelectronic Detection and Imaging (ISPDI) - Infrared Imaging and Applications, Beijing, June 25-27, 2013
作者:
Ai R(艾锐)
;
Shi ZL(史泽林)
;
Xu DJ(徐德江)
;
Zhang CS(张程硕)
收藏
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浏览/下载:38/0
  |  
提交时间:2013/12/26
There exist complex gray mapping relationships among infrared and visible images because of the different imaging mechanisms. The difficulty of infrared and visible image registration is to find a reasonable similarity definition. In this paper, we develop a novel image similarity called implicit linesegment similarity(ILS) and a registration algorithm of infrared and visible images based on ILS. Essentially, the algorithm achieves image registration by aligning the corresponding line segment features in two images. First, we extract line segment features and record their coordinate positions in one of the images, and map these line segments into the second image based on the geometric transformation model. Then we iteratively maximize the degree of similarity between the line segment features and correspondence regions in the second image to obtain the model parameters. The advantage of doing this is no need directly measuring the gray similarity between the two images. We adopt a multi-resolution analysis method to calculate the model parameters from coarse to fine on Gaussian scale space. The geometric transformation parameters are finally obtained by the improved Powell algorithm. Comparative experiments demonstrate that the proposed algorithm can effectively achieve the automatic registration for infrared and visible images, and under considerable accuracy it makes a more significant improvement on computational efficiency and anti-noise ability than previously proposed algorithms.
A Local Image Enhancement Method Based on Adjacent Pixel Gray Order-preserving Principle
会议论文
OAI收割
5th International Symposium on Photoelectronic Detection and Imaging (ISPDI) - Infrared Imaging and Applications, Beijing, June 25-27, 2013
作者:
Fan XP(范晓鹏)
;
Cai TF(蔡铁峰)
;
Zhu F(朱枫)
收藏
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浏览/下载:44/0
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提交时间:2013/12/26
The paper is committed in local image enhancement. At first, the authors propose an adjacent pixel gray order-preserving principle. Adjacent pixel gray order-preserving principle is the basement of local enhancement method which ensures that there is no distortion in processed image. And then, the authors propose an iterative algorithm, which could stretch gray-scale difference of adjacent pixels in premise of not changing gray magnitude relationship between adjacent pixels. At last, the authors propose a totally reference image quality assessment method based on adjacent pixel gray order-preserving principle. According to this quality assessment method, the authors made a set of comparative experiments with local histogram equalization and method. Experimental results show that the proposed enhancement method can get higher score and provide better visual effects, fully demonstrating its effectiveness. According to this quality assessment method, the proposed method shows a good effectiveness, through experimental results and comparison with local histogram equalization method.