中国科学院机构知识库网格
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ABT-263 enhances sorafenib-induced apoptosis associated with Akt activity and the expression of Bax and p21 (CIP1/WAF1) in human cancer cells1
期刊论文
OAI收割
出版物, 3111, 期号: 0, 页码: 1-35
作者:
Jingru Li
;
Yicheng Chen
;
Jiali Wan
;
Xin Liu
;
Chunrong Yu
  |  
收藏
  |  
浏览/下载:261/0
  |  
提交时间:2017/07/24
Abt-263
Sorafenib
Combination Therapy
Cancer
YC-1 inhibits proliferation of breast cancer cells by downregulating EZH2 expression via activation of c-Cbl and ERK
期刊论文
OAI收割
出版物, 3111, 期号: 0, 页码: 1-46
作者:
Ling-Chu Chang
;
Hui-Yi Lin
;
Meng-Tung Tsai
;
Ruey-Hwang Chou
;
Fang-Yu Lee
  |  
收藏
  |  
浏览/下载:293/0
  |  
提交时间:2017/07/24
Yc-1
Triple-negative Breast Cancer
Erk
Ezh2
C-cbl
Metal-organic frameworks (MOFs) for phototherapy and synergistic phototherapy of cancer
期刊论文
OAI收割
COORDINATION CHEMISTRY REVIEWS, 2025, 卷号: 526, 页码: 23
作者:
Tong, Pei-Hong
;
Yang, Jing-Jie
;
Zhou, Yu-Fan
;
Tang, Yi-Fan
;
Tang, Meng-Tian
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2025/02/28
Metal-organic frameworks (MOFs)
Phototherapy
Photodynamic therapy
Photothermal therapy
Synergistic therapy
Cancer
Design, Synthesis, and biological evaluation of 7H-Pyrrolo[2,3-d] pyrimidines as potent HPK1 kinase inhibitors
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2025, 卷号: 119, 页码: 13
作者:
Wu, Feifei
;
Li, Huiyu
;
Li, Weiqiang
;
Zhang, Laishun
;
An, Qi
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/04/01
Optimization
Hematopoietic progenitor kinase 1
Inhibitor
Cancer immunotherapy
Development of novel epoxyketone macrocyclic peptidyl proteasome inhibitors through OPA-mediated one-step cyclization of unprotected peptides
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 156, 页码: 16
作者:
Zeng, Gongruixue
;
Xu, Gaoya
;
Gao, Lixin
;
Zheng, Xiaoli
;
Chi, Xinglong
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2025/04/01
Proteasome inhibitors
Macrocycle
Stability
Anti-cancer activities
A patent review of BRD4 inhibitors (2020-present)
期刊论文
OAI收割
EXPERT OPINION ON THERAPEUTIC PATENTS, 2025, 页码: 16
作者:
Chen, Yanfang
;
Zhou, Huanmin
;
Yu, Jiamin
;
Gao, Jing
;
Xue, Shengyu
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/04/01
BET
BRD4
inhibitor
cancer treatment
selectivity
Discovery of novel covalent stabilizers for p53 Y220C using structure-based drug discovery methods
期刊论文
OAI收割
MOLECULAR DIVERSITY, 2025, 页码: 14
作者:
Wen, Yiming
;
Xu, Peijia
;
Chen, Yijie
;
Meng, Jingyi
;
Zheng, Mingyue
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2025/04/01
p53 Y220C
Covalent stabilizer
Virtual screening
Molecular dynamics
DNA binding
Structure-activity relationship
Cancer therapy
In-situ trichosanthin-IL2/pectin dynamic hydrogel activates dendritic cells and reverses T cell exhaustion for post-operative cancer therapy
期刊论文
OAI收割
CHEMICAL ENGINEERING JOURNAL, 2025, 卷号: 505, 页码: 12
作者:
Gu, Zeyun
;
Chen, Guihua
;
Gao, Nan
;
Yao, Shuo
;
Zhang, Xiaoru
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2025/04/01
Trichosanthin
IL2
Hydrogel
Postoperative administration
Cancer immunotherapy
Dendritic cells
A prodrug nanodevice co-delivering docetaxel and ROR1 siRNA for enhanced triple negative breast cancer therapy
期刊论文
OAI收割
ACTA BIOMATERIALIA, 2025, 卷号: 193, 页码: 498-513
作者:
Yin, Lixuan
;
Fu, Zirang
;
Wang, Mengmeng
;
Liu, Bo
;
Sun, Xujie
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2025/04/01
Triple-negative breast cancer
Docetaxel
Prodrug nanoparticle
ROR1 siRNA
pH responsive
Targeting Mesothelin Enhances Personalized Neoantigen Vaccine Induced Antitumor Immune Response in Orthotopic Pancreatic Cancer Mouse Models
期刊论文
OAI收割
ADVANCED SCIENCE, 2025, 页码: 17
作者:
Cai, Zhixiong
;
Li, Zhenli
;
Zhong, Wenting
;
Lin, Fangzhou
;
Dong, Xiuqing
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2025/04/01
apCAFs
immunotherapy
mesothelin
neoantigen vaccine
pancreatic cancer