中国科学院机构知识库网格系统: 检索

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	Novel tetrahydrobenzo[b]thiophen-2-yl)urea derivatives as novel alpha-glucosidase inhibitors: Synthesis, kinetics study, molecular docking, and in vivo anti-hyperglycemic evaluation 期刊论文 OAI收割 BIOORGANIC CHEMISTRY, 2021, 卷号: 115, 页码: 17 作者: Xie, Hong-Xu; Zhang, Juan; Li, Yue; Zhang, Jin-He; Liu, Shan-Kui \| 收藏 \| 浏览/下载：81/0 \| 提交时间：2021/11/04 Tetrahydrobenzo[b]thiophen-2-yl)urea alpha-Glucosidase inhibitors Non-competitive inhibitor Molecular docking Anti-hyperglycaemic activity Type 2 diabetes
	Interaction assessments of the first S-adenosylmethionine competitive inhibitor and the essential interacting partner methylosome protein 50 with protein arginine methyltransferase 5 by combined computational methods 期刊论文 OAI收割 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 卷号: 495, 期号: 1, 页码: 721-727 作者: Zhu, Kongkai; Jiang, Cheng-Shi; Hu, Junchi; Liu, Xigong; Yan, Xue \| 收藏 \| 浏览/下载：27/0 \| 提交时间：2019/01/08 PRMT5 SAM competitive inhibitor Molecular docking Molecular dynamics simulation Molecular mechanics/Poisson-Boltzmann surface area PRMT5:MEP50 interaction
	Design,synthesis and biological evaluation of benzothiazinones as novel non-ATP competitive inhibitors of glycogen synthesis kinase 3beta (GSK-3beta) 期刊论文 OAI收割 Chinese Journal of Medicinal Chemistry, 2013, 卷号: 23, 期号: 6, 页码: 444-452 作者: Lu Wenbo; Zhang Peng; Huang Ke; Chu Yong; Ye Deyong \| 收藏 \| 浏览/下载：31/0 \| 提交时间：2019/01/08 GSK-3beta synthesis benzothiazinones glycogen synthesis kinase 3beta non-ATP competitive inhibitor structure-activity relationships
	CuAAC Click Chemistry Accelerates the Discovery of Novel Chemical Scaffolds as Promising Protein Tyrosine Phosphatases Inhibitors 期刊论文 OAI收割 CURRENT MEDICINAL CHEMISTRY, 2012, 卷号: 19, 期号: 15, 页码: 2399-2405 作者: He, X. -P. \| 收藏 \| 浏览/下载：23/0 \| 提交时间：2019/01/08 Protein tyrosine phosphatase click chemistry in situ screening drug discovery CuAAC tyrosine phosphorylation dephosphorylation carbohydrate amino acid salicylic acid isoxazole acid ketocarboxylic acid competitive inhibitor bidentate
	Discovery of a novel competitive inhibitor of PTP1B by high-throughput screening 期刊论文 OAI收割 ACTA PHARMACOLOGICA SINICA, 2008, 卷号: 29, 期号: 2, 页码: 278-284 作者: Shi, Lei; Yu, Hai-ping; Zhou, Yue-yang; Du, Jun-qin; Shen, Qiang \| 收藏 \| 浏览/下载：25/0 \| 提交时间：2019/01/08 high throughput screening PTP1B insulin receptor phosphoryaltion competitive inhibitor
	discoveryofanovelcompetitiveinhibitorofptp1bbyhighthroughputscreening 期刊论文 OAI收割 actapharmacologicasinica, 2008, 卷号: 29, 期号: 2, 页码: 278 作者: Lei SHI; Haiping YU; Yueyang ZHOU; Junqin DU; Qiang SHEN \| 收藏 \| 浏览/下载：18/0 \| 提交时间：2020/07/01 PROTEIN-TYROSINE PHOSPHATASE-1B FAO HEPATOMA-CELLS INSULIN SENSITIVITY ADIPOSE-TISSUE OVEREXPRESSION RESISTANCE OBESITY 1B PTP-1B GENE high throughput screening PTP1B insulin receptor phosphoryaltion competitive inhibitor
	Ursolic acid and its derivative inhibit protein tyrosine phosphatase 1B, enhancing insulin receptor phosphorylation and stimulating glucose uptake 期刊论文 OAI收割 BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2006, 卷号: 1760, 期号: 10, 页码: 1505-1512 作者: Zhang, Wei; Hong, Di; Zhou, Yueyang; Zhang, Yinan; Shen, Qiang \| 收藏 \| 浏览/下载：145/0 \| 提交时间：2019/01/08 PTP1B inhibitor ursolic acid traditional Chinese medicinal herb derivative competitive insulin receptor glucose uptake
	Discovery of novel inhibitor of human leukocyte common antigen-related phosphatase 期刊论文 OAI收割 BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2005, 卷号: 1726, 期号: 1, 页码: 34-41 作者: Yang, XN; Li, JY; Zhou, YY; Shen, Q; Chen, JW \| 收藏 \| 浏览/下载：18/0 \| 提交时间：2019/01/08 LAR protein tyrosine phosphatase high-throughput screening competitive inhibitor meD peptide