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机构
长春应用化学研究所 [7]
水生生物研究所 [1]
昆明植物研究所 [1]
上海生物化学与细胞生... [1]
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OAI收割 [10]
内容类型
期刊论文 [10]
发表日期
2014 [1]
2013 [1]
2012 [2]
2011 [1]
2010 [4]
2000 [1]
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学科主题
Biochemist... [1]
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Reduced Graphene Oxide Upconversion Nanoparticle Hybrid for Electrochemiluminescent Sensing of a Prognostic Indicator in Early-Stage Cancer
期刊论文
OAI收割
small, 2014, 卷号: 10, 期号: 2, 页码: 330-336
Wu, Li
;
Wang, Jiasi
;
Yin, Meili
;
Ren,Jinsong
;
Miyoshi,Daisuke
;
Sugimoto,Naoki
;
Qu,Xiaogang
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2015/03/26
CYCLIN-DEPENDENT KINASES
CELL-CYCLE
ELECTROGENERATED CHEMILUMINESCENCE
FUNCTIONALIZED GRAPHENE
CARBON NANOTUBES
POLYMER BRUSHES
DNA-REPLICATION
BREAST-CANCER
A EXPRESSION
K562 CELLS
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells
期刊论文
OAI收割
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:
Zeng, Guang-Zhi
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2015/05/14
2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA)
one of the major components isolated from the traditional
Chinese medicine Rubia yunnanensis
exhibited inhibitory activity on the proliferation of several
human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay
and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle
arrest in human cervical carcinoma HeLa cells. Further
MTA was found to induce apoptosis of HeLa cells
through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and
release of cytochrome c into the cytosol
which caused the cleavage of caspase and poly(ADP-ribose)
polymerase and finally triggered the apoptosis. Furthermore
the p53/p21/Cdc2-cyclin B1 signaling was
found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of
cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused
the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of
R. yunnanensis
a folk anti-cancer herb used in Yunnan
China.
Metallosupramolecular complex targeting an alpha/beta discordant stretch of amyloid beta peptide
期刊论文
OAI收割
chemical science, 2012, 卷号: 3, 期号: 11, 页码: 3145-3153
Yu HJ
;
Li M
;
Liu, GP
;
Geng J
;
Wang JZ
;
Ren JS
;
Zhao CQ
;
Qu XG
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2013/04/22
LONG-TERM POTENTIATION
ALZHEIMERS-DISEASE
FIBRIL FORMATION
MOUSE MODEL
A-BETA
IN-VITRO
CYCLIN A(2)
AGGREGATION
INHIBITORS
OLIGOMERS
Detection of a Prognostic Indicator in Early-Stage Cancer Using Functionalized Graphene-Based Peptide Sensors
期刊论文
OAI收割
advanced materials, 2012, 卷号: 24, 期号: 1, 页码: 125-131
Feng LY
;
Wu L
;
Wang JS
;
Ren JS
;
Miyoshi D
;
Sugimoto N
;
Qu XG
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2013/09/03
WALLED CARBON NANOTUBES
HUMAN CYCLIN A(2)
CELL-CYCLE
NONCOVALENT FUNCTIONALIZATION
PROTEIN MICROARRAYS
CATALYTIC-ACTIVITY
DNA-REPLICATION
K562 CELLS
OXIDE
EXPRESSION
Label-free colorimetric and quantitative detection of cancer marker protein using noncrosslinking aggregation of Au/Ag nanoparticles induced by target-specific peptide probe
期刊论文
OAI收割
biosensors & bioelectronics, 2011, 卷号: 26, 期号: 12, 页码: 4804-4809
Wang XH
;
Wu L
;
Ren JS
;
Miyoshi D
;
Sugimoto N
;
Qu XG
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2012/06/08
CYCLIN-A EXPRESSION
UNMODIFIED GOLD NANOPARTICLES
SILVER NANOPARTICLES
CELL-PROLIFERATION
MOLECULAR BEACONS
CARBON NANOTUBES
DNA-REPLICATION
K562 CELLS
ASSAY
A(2)
Osteogenic growth peptide enhances the proliferation of bone marrow mesenchymal stem cells from osteoprotegerin-deficient mice by CDK2/cyclin A
期刊论文
OAI收割
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2010, 卷号: 42, 期号: 11, 页码: 801-806
作者:
Fei, QM
;
Guo, CJ
;
Xu, XY
;
Gao, JJ
;
Zhang, JA
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2015/07/22
osteogenic growth peptide
osteoprotegerin
mesenchymal stem cell
cell proliferation
CDK2
cyclin A
Ultrasensitive and Selective Detection of a Prognostic Indicator in Early-Stage Cancer Using Graphene Oxide and Carbon Nanotubes
期刊论文
OAI收割
advanced functional materials, 2010, 卷号: 20, 期号: 22, 页码: 3967-3971
Wang XH
;
Wang CY
;
Qu KG
;
Song YJ
;
Ren JS
;
Miyoshi D
;
Sugimoto N
;
Qu XG
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2012/04/25
CROSS-CORRELATION SPECTROSCOPY
HUMAN CYCLIN A(2)
CELL-CYCLE
PEPTIDE BEACONS
EPITAXIAL GRAPHENE
MOLECULAR BEACONS
PROTEIN-DETECTION
DNA-REPLICATION
FLUORESCENCE
EXPRESSION
Label-Free Colorimetric Detection of Single Nucleotide Polymorphism by Using Single-Walled Carbon Nanotube Intrinsic Peroxidase-Like Activity
期刊论文
OAI收割
chemistry-a european journal, 2010, 卷号: 16, 期号: 12, 页码: 3617-3621
Song YJ
;
Wang XH
;
Zhao C
;
Qu KG
;
Ren JS
;
Qu XG
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2012/06/07
BAND-GAP FLUORESCENCE
I-MOTIF DNA
HYDROGEN-PEROXIDE
MODIFIED ELECTRODES
REDOX REACTION
CYCLIN A(2)
K562 CELLS
BINDING
HYBRIDS
BIOAPPLICATIONS
DNA Loop Sequence as the Determinant for Chiral Supramolecular Compound G-Quadruplex Selectivity
期刊论文
OAI收割
journal of medicinal chemistry, 2010, 卷号: 53, 期号: 1, 页码: 492-498
Yu HJ
;
Zhao CQ
;
Chen Y
;
Fu ML
;
Ren JS
;
Qu XG
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2012/06/07
TELOMERIC G-QUADRUPLEX
IN-VIVO
G-TETRAPLEX
POTASSIUM SOLUTION
QUANTITATIVE PCR
CYCLIN A(2)
K562 CELLS
LENGTH
SENESCENCE
REPEAT
银鲫与彩鲫卵母细胞cDNA文库构建及周期蛋白A_1的cDNA克隆
期刊论文
OAI收割
水生生物学报, 2000, 期号: 6
樊连春,谢京,汪洋,桂建芳
收藏
  |  
浏览/下载:242/11
  |  
提交时间:2010/10/13
雌核发育
银鲫
两性生殖
彩鲫
cDNA文库
细胞周期
Cyclin A_1