中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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浏览/检索结果: 共10条,第1-10条 帮助

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Reduced Graphene Oxide Upconversion Nanoparticle Hybrid for Electrochemiluminescent Sensing of a Prognostic Indicator in Early-Stage Cancer 期刊论文  OAI收割
small, 2014, 卷号: 10, 期号: 2, 页码: 330-336
Wu, Li; Wang, Jiasi; Yin, Meili; Ren,Jinsong; Miyoshi,Daisuke; Sugimoto,Naoki; Qu,Xiaogang
收藏  |  浏览/下载:23/0  |  提交时间:2015/03/26
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文  OAI收割
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  
Zeng, Guang-Zhi
收藏  |  浏览/下载:44/0  |  提交时间:2015/05/14
2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA)  one of the major components isolated from the traditional  Chinese medicine Rubia yunnanensis  exhibited inhibitory activity on the proliferation of several  human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay  and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle  arrest in human cervical carcinoma HeLa cells. Further  MTA was found to induce apoptosis of HeLa cells  through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and  release of cytochrome c into the cytosol  which caused the cleavage of caspase and poly(ADP-ribose)  polymerase and finally triggered the apoptosis. Furthermore  the p53/p21/Cdc2-cyclin B1 signaling was  found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of  cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused  the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of  R. yunnanensis  a folk anti-cancer herb used in Yunnan  China.  
Metallosupramolecular complex targeting an alpha/beta discordant stretch of amyloid beta peptide 期刊论文  OAI收割
chemical science, 2012, 卷号: 3, 期号: 11, 页码: 3145-3153
Yu HJ; Li M; Liu, GP; Geng J; Wang JZ; Ren JS; Zhao CQ; Qu XG
收藏  |  浏览/下载:21/0  |  提交时间:2013/04/22
Detection of a Prognostic Indicator in Early-Stage Cancer Using Functionalized Graphene-Based Peptide Sensors 期刊论文  OAI收割
advanced materials, 2012, 卷号: 24, 期号: 1, 页码: 125-131
Feng LY; Wu L; Wang JS; Ren JS; Miyoshi D; Sugimoto N; Qu XG
收藏  |  浏览/下载:14/0  |  提交时间:2013/09/03
Label-free colorimetric and quantitative detection of cancer marker protein using noncrosslinking aggregation of Au/Ag nanoparticles induced by target-specific peptide probe 期刊论文  OAI收割
biosensors & bioelectronics, 2011, 卷号: 26, 期号: 12, 页码: 4804-4809
Wang XH; Wu L; Ren JS; Miyoshi D; Sugimoto N; Qu XG
收藏  |  浏览/下载:24/0  |  提交时间:2012/06/08
Osteogenic growth peptide enhances the proliferation of bone marrow mesenchymal stem cells from osteoprotegerin-deficient mice by CDK2/cyclin A 期刊论文  OAI收割
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2010, 卷号: 42, 期号: 11, 页码: 801-806
作者:  
Fei, QM;  Guo, CJ;  Xu, XY;  Gao, JJ;  Zhang, JA
收藏  |  浏览/下载:29/0  |  提交时间:2015/07/22
Ultrasensitive and Selective Detection of a Prognostic Indicator in Early-Stage Cancer Using Graphene Oxide and Carbon Nanotubes 期刊论文  OAI收割
advanced functional materials, 2010, 卷号: 20, 期号: 22, 页码: 3967-3971
Wang XH; Wang CY; Qu KG; Song YJ; Ren JS; Miyoshi D; Sugimoto N; Qu XG
收藏  |  浏览/下载:20/0  |  提交时间:2012/04/25
Label-Free Colorimetric Detection of Single Nucleotide Polymorphism by Using Single-Walled Carbon Nanotube Intrinsic Peroxidase-Like Activity 期刊论文  OAI收割
chemistry-a european journal, 2010, 卷号: 16, 期号: 12, 页码: 3617-3621
Song YJ; Wang XH; Zhao C; Qu KG; Ren JS; Qu XG
收藏  |  浏览/下载:22/0  |  提交时间:2012/06/07
DNA Loop Sequence as the Determinant for Chiral Supramolecular Compound G-Quadruplex Selectivity 期刊论文  OAI收割
journal of medicinal chemistry, 2010, 卷号: 53, 期号: 1, 页码: 492-498
Yu HJ; Zhao CQ; Chen Y; Fu ML; Ren JS; Qu XG
收藏  |  浏览/下载:17/0  |  提交时间:2012/06/07
银鲫与彩鲫卵母细胞cDNA文库构建及周期蛋白A_1的cDNA克隆 期刊论文  OAI收割
水生生物学报, 2000, 期号: 6
樊连春,谢京,汪洋,桂建芳
收藏  |  浏览/下载:242/11  |  提交时间:2010/10/13