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	Terpenoids from Nardostachys jatamansi and Their Cytotoxic Activity against Human Pancreatic Cancer Cell Lines 期刊论文 OAI收割 Phytochemistry, 2022, 期号: 200, 页码: 113228 作者: Li-Mei Ma; Kai Wang; Xian-Hua Meng; Yi-Dan Zheng; Cheng-Bo Wang \| 收藏 \| 浏览/下载：41/0 \| 提交时间：2022/11/30 Nardostachys jatamansi DC. Valerianaceae Terpenoids Cytotoxicity Human pancreatic cancer cell lines
	Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文 OAI收割 PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299 作者: Zeng, Guang-Zhi; Fan, Jun-Ting; Xu, Jun-Ju; Li, Yan; Tan, Ning-Hua 收藏 \| 浏览/下载：47/0 \| 提交时间：2015/05/14 2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA) one of the major components isolated from the traditional Chinese medicine Rubia yunnanensis exhibited inhibitory activity on the proliferation of several human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle arrest in human cervical carcinoma HeLa cells. Further MTA was found to induce apoptosis of HeLa cells through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and release of cytochrome c into the cytosol which caused the cleavage of caspase and poly(ADP-ribose) polymerase and finally triggered the apoptosis. Furthermore the p53/p21/Cdc2-cyclin B1 signaling was found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of R. yunnanensis a folk anti-cancer herb used in Yunnan China.
	Apoptosis of human pancreatic carcinoma cells induced by all-trans retinoic acid and interferon 期刊论文 OAI收割 CHINESE JOURNAL OF CANCER RESEARCH, 2009, 卷号: 21, 期号: 3, 页码: 224-228 作者: Wang Xiaohua; Yin Yuanqin; Ma Ping; Sui Chengguang; Meng Fandong \| 收藏 \| 浏览/下载：15/0 \| 提交时间：2021/02/02 CANCER EXPRESSION INHIBITION RESISTANCE LINES ALPHA All-trans retinoic acid (ATRA) Interferon-alpha (IFN-alpha) Apoptosis Human pancreatic carcinoma cells
	Ethyl acetate extracted from Shiitake Mushroom induced apoptosis in a breast cancer cell line-MCF-7 期刊论文 OAI收割 Chinese Pharmacological Bulletin, 2006, 卷号: 22, 期号: 8, 页码: 1001-1004 作者: LI Qinglin; LUO Hongfeng; FANG Nianbai \| 收藏 \| 浏览/下载：14/0 \| 提交时间：2019/01/08 MCF-7 ethyl acetate extract of shiitake mushroom MCF-7 human breast cancer cell lines apoptosis cell cycle
	Megathyrin B: A cytotoxic diterpene from Isodon megathyrsus 期刊论文 OAI收割 PLANTA MEDICA, 1998, 卷号: 64, 期号: 8, 页码: 728-731 作者: Qiu, SX; Sun, HD; Lobkovsky, E; Chai, H; Clardy, I 收藏 \| 浏览/下载：30/0 \| 提交时间：2015/08/17 Isodon megathyrsus Labiatae leaves ent-kaurene diterpene human cancer lines cytotoxic activity 2D-NMR techniques X-ray crystallography megathyrin B electrospray LC/MS