中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
大连化学物理研究所 [14]
上海药物研究所 [3]
化学研究所 [1]
采集方式
OAI收割 [17]
iSwitch采集 [1]
内容类型
期刊论文 [18]
发表日期
2019 [2]
2017 [2]
2016 [1]
2015 [2]
2014 [1]
2013 [2]
更多
学科主题
物理化学 [3]
Chemistry [1]
Physics [1]
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浏览/检索结果:
共18条,第1-10条
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Cytochrome P450 3A Enzymes Are Key Contributors for Hepatic Metabolism of Bufotalin, a Natural Constitute in Chinese Medicine Chansu
期刊论文
OAI收割
FRONTIERS IN PHARMACOLOGY, 2019, 卷号: 10, 页码: 10
作者:
Ma, Hong-Ping
;
Dai, Zi-Ru
;
Ning, Jing
;
Sun, Gui-Bo
;
Wang, Ping
  |  
收藏
  |  
浏览/下载:75/0
  |  
提交时间:2019/06/20
bufotalin
cytochrome P450 3A (CYP3A)
hydroxylation
human liver microsomes (HLMs)
docking simulations
Cytochrome p450 3a enzymes are key contributors for hepatic metabolism of bufotalin, a natural constitute in chinese medicine chansu
期刊论文
iSwitch采集
Frontiers in pharmacology, 2019, 卷号: 10, 页码: 10
作者:
Dai, Zi-Ru
;
Ning, Jing
;
Sun, Gui-Bo
;
Wang, Ping
;
Zhang, Feng
收藏
  |  
浏览/下载:106/0
  |  
提交时间:2019/05/08
Bufotalin
Cytochrome p450 3a (cyp3a)
Hydroxylation
Human liver microsomes (hlms)
Docking simulations
Metabolic profiling of five flavonoids from Dragon's Blood in human liver microsomes using high-performance liquid chromatography coupled with high resolution mass spectrometry
期刊论文
OAI收割
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2017, 卷号: 1052, 页码: 91-102
作者:
Li, Yujuan
;
Zhang, Yushi
;
Wang, Rui
;
Wei, Lizhong
;
Deng, Yulin
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2018/04/10
Dragon's Blood
Human Liver Microsomes
Hplc-hr-ms
Metabolites
Identification of human UDP-glucuronosyltransferase isoforms involved in the isofraxidin glucuronidation and assessment of the species differences of the reaction
期刊论文
OAI收割
FITOTERAPIA, 2017, 卷号: 117, 页码: 118-125
作者:
Meng, Fanxing
;
Li, Yan
;
He, Guiyuan
;
Ge, Guangbo
;
Liu, Shumin
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/06/20
Isofraxidin
Udp-glucuronosyltransferases (Ugts)
Human Liver Microsomes (Hlm)
Human Intestinal Microsomes (Him)
Species Differences
Chronic administration of caderofloxacin, a new fluoroquinolone, increases hepatic CYP2E1 expression and activity in rats
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 4, 页码: 561
作者:
Liu Li
;
Miao Mingxing
;
Zhong Zeyu
;
Xu Ping
;
Chen Yang
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/12/24
VIVO ANTIBACTERIAL ACTIVITIES
DRUG-DRUG INTERACTIONS
HUMAN LIVER-MICROSOMES
IN-VIVO
CYTOCHROME-P450 ENZYMES
HEALTHY-VOLUNTEERS
COCKTAIL APPROACH
METABOLISM
QUINOLONE
CS-940
caderofloxacin
cocktail approach
chlorzoxazone
CYP2E1
pharmacokinetics
drug-drug interaction
In Vitro Evaluation of the Effect of 7-Methyl Substitution on Glucuronidation of Daphnetin: Metabolic Stability, Isoform Selectivity, and Bioactivity Analysis
期刊论文
OAI收割
journal of pharmaceutical sciences, 2015, 卷号: 104, 期号: 10, 页码: 3557-3564
作者:
Liang, Si-Cheng
;
Ge, Guang-Bo
;
Xia, Yang-Liu
;
Zhang, Jiang-Wei
;
Qi, Xiao-Yi
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2015/11/17
daphnetin
glucuronidation
methyl substitution
structural modification
metabolic stability
phase II enzymes
glucuronosyltransferases
human liver microsomes
enzyme kinetics
metabolic clearance
Inhibition of human cytochrome P450 enzymes by licochalcone A, a naturally occurring constituent of licorice
期刊论文
OAI收割
toxicology in vitro, 2015, 卷号: 29, 期号: 7, 页码: 1569-1576
作者:
He, Wei
;
Wu, Jing-Jing
;
Ning, Jing
;
Hou, Jie
;
Xin, Hong
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2015/11/17
Licochalcone A (LCA)
Human liver microsomes (HLMs)
Cytochrome P450 enzymes (CYPs)
Inhibition
Herb-drug interactions (HDIs)
Identification and Characterization of Human UDP-glucuronosyltransferases Responsible for the Glucuronidation of Fraxetin
期刊论文
OAI收割
drug metabolism and pharmacokinetics, 2014, 卷号: 29, 期号: 2, 页码: 135-140
作者:
Xia, Yang-Liu
;
Liang, Si-Cheng
;
Zhu, Liang-Liang
;
Ge, Guang-Bo
;
He, Gui-Yuan
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2015/11/16
fraxetin
UDP-glucuronosyltransferases (UGTs)
UGT1A9
glucuronidation
human liver microsomes (HLMs)
Inhibitory effects of sanguinarine on human liver cytochrome P450 enzymes
期刊论文
OAI收割
food and chemical toxicology, 2013, 卷号: 56, 页码: 392-397
作者:
Qi, Xiao-Yi
;
Liang, Si-Cheng
;
Ge, Guang-Bo
;
Liu, Yong
;
Dong, Pei-Pei
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2014/09/11
Sanguinarine
Human liver microsomes
Cytochrome P450 enzyme
Drug-drug interaction
Time-dependent inhibition
Investigation of the in Vitro Metabolism of Evodiamine: Characterization of Metabolites and Involved Cytochrome P450 Isoforms
期刊论文
OAI收割
phytotherapy research, 2013, 卷号: 27, 期号: 5, 页码: 705-712
作者:
Sun, Hong-Zhi
;
Fang, Zhong-Ze
;
Cao, Yun-Feng
;
Sun, Xiao-Yu
;
Hong, Mo
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2015/11/09
evodiamine
cytochrome P450 (CYP)
human liver microsomes (HLMs)