机构

• 上海药物研究所 [68]
• 兰州化学物理研究所 [5]
• 化学研究所 [4]
• 大连化学物理研究所 [4]
• 中国科学院大学 [4]
• 西北高原生物研究所 [3]
• 更多

采集方式

• OAI收割 [92]
• iSwitch采集 [4]

内容类型

• 期刊论文 [95]
• 学位论文 [1]

发表日期

• 2024 [3]
• 2023 [4]
• 2022 [5]
• 2021 [3]
• 2020 [9]
• 2019 [6]
• 更多

学科主题

• Chemistry [3]
• 分析化学与药物化学 [3]
• Biochemist... [2]
• Pharmacolo... [2]
• Biochemist... [1]
• Biotechnol... [1]
• 更多

筛选

浏览/检索结果: 共96条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 DNA-Encoded Noncanonical Substrate Library for Protease Profiling 期刊论文  OAI收割 CHEMBIOCHEM, 2024, 页码: 12 作者:  Zhang, Huiya;  Xing, Yuyu;  Yang, Yixuan;  Tang, Bixi;  Zong, Zhaoyun   |  收藏  |  浏览/下载：75/0  |  提交时间：2024/12/16 Protease substrate  DNA-encoded library  Combinatorial peptide library  High-throughput screening  Covalent inhibitor  Noncanonical peptide   In silico Exploration of Inhibition Mechanism of Lianhua Qingwen Formula (LQF) Interaction on SARS-CoV-2 Mpro 期刊论文  OAI收割 CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2024, 页码: 13 作者:  Xue, Xiaolong;  Wang, Xin;  Ye, Chenghao;  Gao, Meina;  Li, Peng   |  收藏  |  浏览/下载：18/0  |  提交时间：2024/10/21 SARS-CoV-2 Mpro inhibitor  Lianhua Qingwen Formula (LQF)  Virtual screening  S1 ' subsite  SARS-CoV Mpro inhibitor   Discovery of hematopoietic progenitor kinase 1 inhibitors using machine learning-based screening and free energy perturbation 期刊论文  OAI收割 JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2024, 页码: 13 作者:  Feng, Dazhi;  Liu, Bo;  Chen, Zhiwei;  Xu, Jinyi;  Geng, Meiyu   |  收藏  |  浏览/下载：46/0  |  提交时间：2024/02/27 HPK1 inhibitor  machine learning  virtual screening  free energy perturbation  structural modification   Discovery of novel cGAS inhibitors based on natural flavonoids 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2023, 卷号: 140, 页码: 14 作者:  Li, Jiameng;  Xiong, Muya;  Liu, Jiayuan;  Zhang, Fengping;  Li, Minjun   |  收藏  |  浏览/下载：14/0  |  提交时间：2023/12/08 Cyclic GMP-AMP synthase  Inhibitor  Flavonoids  Crystal structure  Virtual screening   Discovery of a novel OGT inhibitor through high-throughput screening based on Homogeneous Time-Resolved Fluorescence (HTRF) 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2023, 卷号: 139, 页码: 12 作者:  Wu, Xinyu;  Wang, Mingchen;  Cao, Yu;  Xu, Ying;  Yang, Ziqun   |  收藏  |  浏览/下载：16/0  |  提交时间：2024/02/27 O-GlcNAcylation  O-GlcNAc transferase  High-throughput screening  Inhibitor   Design, Construction, and Screening of Diversified Pyrimidine-Focused DNA-Encoded Libraries 期刊论文  OAI收割 ACS MEDICINAL CHEMISTRY LETTERS, 2023, 卷号: 14, 期号: 8, 页码: 1073-1078 作者:  Seydimemet, Mengnisa;  Yang, Yixuan;  Lv, Yuhan;  Liu, Jiaxiang;  Yan, Ziqin   |  收藏  |  浏览/下载：24/0  |  提交时间：2023/10/17 DNA-encoded library technology  Pyrimidine-focusedDNA-encodedlibrary  BRD4  Affinity screening  Inhibitor   Thimerosal, a competitive thioredoxin reductase 1 (TrxR1) inhibitor discovered via high-throughput screening 期刊论文  OAI收割 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2023, 卷号: 650, 页码: 117-122 作者:  Ni, Yicheng;  Luo, Zhongyuan;  Lv, Yixin;  Ma, Shuyuan;  Luo, Cheng   |  收藏  |  浏览/下载：25/0  |  提交时间：2023/10/17 Thioredoxin reductase 1 inhibitor  Chemical probe  High -throughput screening  Thimerosal   Structure-based design of a novel inhibitor of the ZIKA virus NS2B/ NS3 protease 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2022, 卷号: 128, 页码: 7 作者:  Xiong, Yanchao;  Cheng, Fei;  Zhang, Junyi;  Su, Haixia;  Hu, Hangchen   |  收藏  |  浏览/下载：38/0  |  提交时间：2022/11/11 Zika virus  Fragment -based hit screening  Protein -inhibitor interactions  NS2B  NS3 protease  Crystal structure   Discovery and characterization of a novel cGAS covalent inhibitor for the treatment of inflammatory bowel disease 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2022, 页码: 10 作者:  Song, Jia;  Yang, Rui-rui;  Chang, Jie;  Liu, Ya-dan;  Lu, Cheng-hao   |  收藏  |  浏览/下载：67/0  |  提交时间：2022/11/11 cyclic GMP-AMP synthase  covalent inhibitor  inflammatory bowel disease  high-throughput screening   The discovery of a non-competitive GOT1 inhibitor, hydralazine hydrochloride, via a coupling reaction-based high-throughput screening assay 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2022, 卷号: 73, 页码: 6 作者:  Wu, Qiqi;  Sun, Zhongya;  Chen, Zhifeng;  Liu, Jingqiu;  Ding, Hong   |  收藏  |  浏览/下载：72/0  |  提交时间：2022/08/30 Glutamate oxaloacetate transaminase 1  Inhibitor  Hydralazine hydrochloride  High -throughput screening