中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [9]
上海生物化学与细胞生... [6]
生物物理研究所 [2]
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期刊论文 [31]
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2022 [2]
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Discovery of 4-cyclopropyl-3-(2-((1-cyclopropyl-1H-pyrazol-4-yl) amino) quinazolin-6-yl)-N-(3-(trifluoromethyl) phenyl) benzamides as potent discoidin domain receptor inhibitors for the treatment of idiopathic pulmonary fibrosis
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2022, 卷号: 12, 期号: 4, 页码: 1943-1962
作者:
Wang, Qi
;
Tang, Bixi
;
Sun, Dandan
;
Dong, Ying
;
Ji, Yinchun
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2022/08/16
Idiopathic pulmonary fibrosis
Discoidin domain receptor
Kinase
Inhibitor
Docking
Loss of MLKL ameliorates liver fibrosis by inhibiting hepatocyte necroptosis and hepatic stellate cell activation
期刊论文
OAI收割
THERANOSTICS, 2022, 卷号: 12, 期号: 11, 页码: 5220-5236
作者:
Guo, Ren
;
Jia, Xiaohui
;
Ding, Zhenbin
;
Wang, Gang
;
Jiang, Mengmeng
  |  
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2022/08/30
Mixed lineage kinase domain-like protein
MLKL
liver fibrosis
liver parenchymal cells
hepatocyte
hepatic stellate cells
necroptosis
PKZ, a Fish-Unique eIF2 alpha Kinase Involved in Innate Immune Response
期刊论文
OAI收割
FRONTIERS IN IMMUNOLOGY, 2020, 卷号: 11, 期号: 1, 页码: 6
作者:
Wu, Chuxin
;
Zhang, Yibing
;
Hu, Chengyu
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/05/28
PKZ
Z alpha domain
Z-DNA
kinase activity
fish
Membrane-bound TNF mediates microtubule-targeting chemotherapeutics-induced cancer cytolysis via juxtacrine inter-cancer-cell death signaling
期刊论文
OAI收割
CELL DEATH AND DIFFERENTIATION, 2020, 卷号: 27, 期号: 5, 页码: 1569-1587
作者:
Zhang, Jing
;
Yang, Yu
;
Zhou, Shenao
;
Wu, Chenlu
;
Qin, Jie
  |  
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2020/12/21
TUMOR-NECROSIS-FACTOR
MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN
FACTOR-ALPHA PROMOTER
PROGRAMMED NECROSIS
RECOMBINANT HUMAN
L929 CELLS
APOPTOSIS
ACTIVATION
EXPRESSION
Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism
期刊论文
OAI收割
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 卷号: 293, 期号: 24, 页码: 9370-9387
作者:
Lei, Saifei
;
Clydesdale, Lachlan
;
Dai, Antao
;
Cai, Xiaoqing
;
Feng, Yang
  |  
收藏
  |  
浏览/下载:63/0
  |  
提交时间:2019/01/08
G protein-coupled receptor (GPCR)
glucagon
receptor structure-function
cell signaling
site-directed mutagenesis
biased agonism
GLP-1 receptor
glucagon-like peptide-1
class B peptide hormone
ERK kinase
arrestin
transmembrane domain
Targeting HER2 Aberrations in Non-Small Cell Lung Cancer with Osimertinib
期刊论文
OAI收割
CLINICAL CANCER RESEARCH, 2018, 卷号: 24, 期号: 11, 页码: 2594-2604
作者:
Liu, Shengwu
;
Hai, Josephine
;
Wang, Xiaoen
;
Quinn, Max M.
;
Gao, Peng
  |  
收藏
  |  
浏览/下载:95/0
  |  
提交时间:2019/04/28
Receptor Tyrosine Kinase
Phase-ii Trial
Bromodomain Inhibition
Combination Therapy
Acquired-resistance
Domain Mutations
Bet Bromodomains
Breast-cancer
Egfr
Mutant
Crystal structures of the kinase domain of PpkA, a key regulatory component of T6SS, reveal a general inhibitory mechanism
期刊论文
OAI收割
BIOCHEMICAL JOURNAL, 2018, 卷号: 475, 期号: -, 页码: 2209-2224
作者:
Li, PP
;
Xu, DQ
;
Ma, TQ
;
Wang, DY
;
Li, WD
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收藏
  |  
浏览/下载:33/0
  |  
提交时间:2019/12/17
VI SECRETION SYSTEM
DEPENDENT PROTEIN-KINASE
GRAM-NEGATIVE BACTERIA
MYCOBACTERIUM-TUBERCULOSIS
SERINE/THREONINE KINASE
CATALYTIC DOMAIN
CONFORMATIONAL PLASTICITY
PSEUDOMONAS-AERUGINOSA
ACTIVATION MECHANISM
EDWARDSIELLA-TARDA
RIPK3/Fas-Associated Death Domain Axis Regulates Pulmonary Immunopathology to Cryptococcal Infection Independent of Necroptosis
期刊论文
OAI收割
FRONTIERS IN IMMUNOLOGY, 2017, 卷号: 8, 期号: -, 页码: 1055
作者:
Fa, Zhenzong
;
Pan, Weihua
;
Liao, Wanqing
;
Fang, Wei
;
Olszewski, Michal A.
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/12/09
Cryptococcus neoformans
immune responses
inflammation
Fas-associated death domain
receptor-interacting serine/threonine kinase 3
RIPK3/Fas-Associated Death Domain Axis Regulates Pulmonary Immunopathology to Cryptococcal Infection Independent of Necroptosis
期刊论文
OAI收割
FRONTIERS IN IMMUNOLOGY, 2017, 卷号: 8, 期号: -, 页码: 1055
作者:
Fa, Zhenzong
;
Pan, Weihua
;
Liao, Wanqing
;
Fang, Wei
;
Olszewski, Michal A.
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/12/09
Cryptococcus neoformans
immune responses
inflammation
Fas-associated death domain
receptor-interacting serine/threonine kinase 3