中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [674]
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A Novel Bifunctional Alginate Lyase and Antioxidant Activity of the Enzymatic Hydrolysates
期刊论文
OAI收割
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2024, 卷号: 72, 期号: 8, 页码: 4116-4126
作者:
Gu, Xiaoqian
;
Fu, Liping
;
Wang, Zhiyan
;
Cao, Zhe
;
Zhao, Luying
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2024/04/07
bifunctional alginatelyase
alginate oligosaccharides
antioxidant activity
Discovery of a CB2 and 5-HT1A receptor dual agonist for the treatment of depression and anxiety
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 20
作者:
Yang, Wenjiao
;
Gong, Xudong
;
Sun, Haiguo
;
Wu, Chunhui
;
Suo, Jin
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2024/03/06
CB2R agonist
5-HT1AR agonist
CB1R antagonist
Antidepressant
Anxiolytic
New chromone derivatives bearing thiazolidine-2,4-dione moiety as potent PTP1B inhibitors: Synthesis and biological activity evaluation
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 143, 页码: 9
作者:
Zheng, Yingying
;
Lu, Li
;
Li, Mengyue
;
Xu, Dehua
;
Zhang, Laishun
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/01/26
Chromone
Thiazolidine-2
4-dione
Protein tyrosine phosphatase 1B
Inhibitors
Bialorastins A-F, highly oxygenated and polycyclic andrastin-type meroterpenoids with proangiogenic activity from the deep-sea cold-seep-derived fungus Penicillium bialowiezense CS-283
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 143, 页码: 12
作者:
Yan, Li-Hong
;
Li, Pei-Hai
;
Li, Xiao-Ming
;
Yang, Sui-Qun
;
Liu, Ke-Chun
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2024/04/07
Cold-seep
Penicillium bialowiezense
Meroterpenoids
Proangiogenic activity
Platanosides from Platanus x acerifolia: New molecules, SAR, and target validation of a strong lead for drug-resistant bacterial infections and the associated sepsis
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 143, 页码: 9
作者:
Wu, Xi-Ying
;
Zhao, Ze-Yu
;
Osman, Ezzat E. A.
;
Wang, Xiao-Juan
;
Choo, Yeun-Mun
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/03/06
Platanus x acerifolia
Platanosides
Molecular ion networking (MoIN)
Antibacterial
Staphylococcus aureus
Enterococcus faecium
Structure -activity relationship (SAR)
Molecular docking
Target validation
Design and synthesis of cantharidin derivative DCZ5418 as a TRIP13 inhibitor with anti-multiple myeloma activity
in
vitro
and
in
vivo
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 98, 页码: 7
作者:
Dong, Sanfeng
;
Hu, Ke
;
Shi, Yulong
;
Wang, Guanli
;
Yu, Dandan
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/02/19
Multiple myeloma
TRIP13 inhibitor
Cantharidin
DCZ5418
DCZ0415
D3Rings: A Fast and Accurate Method for Ring System Identification and Deep Generation of Drug-Like Cyclic Compounds
期刊论文
OAI收割
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2024, 卷号: 64, 期号: 3, 页码: 724-736
作者:
Ma, Minfei
;
Zhang, Xinben
;
Zhou, Liping
;
Han, Zijian
;
Shi, Yulong
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2024/03/13
Dual-Type Marker Fusion-Based Underwater Visual Localization for Autonomous Docking
期刊论文
OAI收割
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT, 2024, 卷号: 73, 页码: 11
作者:
Zhao, Chunyang
;
Dong, Huijie
;
Wang, Jian
;
Qiao, Tiezhu
;
Yu, Junzhi
  |  
收藏
  |  
浏览/下载:132/0
  |  
提交时间:2024/03/26
Autonomous docking
dual-type marker fusion
underwater robot
visual localization
Nardostachys jatamansi and levodopa combination alleviates Parkinson's disease symptoms in rats through activation of Nrf2 and inhibition of NLRP3 signaling pathways
期刊论文
OAI收割
PHARMACEUTICAL BIOLOGY, 2023, 卷号: 61, 期号: 1, 页码: 1175-1185
作者:
Li, Jiayuan
;
Yu, Jiahe
;
Guo, Jianyou
;
Liu, Jinfeng
;
Wan, Guohui
  |  
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2023/10/09
Dyskinesia
neurotransmitters
dopaminergic neurons
nardosinone
molecular docking
oxidative stress
neuroinflammation
>
Cryptotanshinone regulates gut microbiota and PI3K-AKT pathway in rats to alleviate CUMS induced depressive symptoms
期刊论文
OAI收割
BIOMEDICINE & PHARMACOTHERAPY, 2023, 卷号: 169, 页码: 11
作者:
Bian, Li-hua
;
Wang, Si-qi
;
Li, Wen-jing
;
Li, Jie
;
Yin, Yi
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/01/18
Depression
Cryptotanshinone
16 S rDNA
Transcriptomics
PI3K-AKT pathway