中国科学院机构知识库网格系统: 检索

Genome-wide transcriptome profiling and characterization of mannuronan C5-epimerases in Saccharina japonica 期刊论文 OAI收割
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS, 2021, 卷号: 60, 页码: 9
作者: Zhang Pengyan; Lu Chang; Shao Zhanru; Liu Fuli; Yao Jianting

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Alginate Mannuronan C5-epimerase M/G ratio Saccharina japonica Transcription profile

Epitranscriptomic 5-Methylcytosine Profile in PM2.5-induced Mouse Pulmonary Fibrosis 期刊论文 OAI收割
GENOMICS PROTEOMICS & BIOINFORMATICS, 2020, 卷号: 18, 期号: 1, 页码: 41-51
作者: Han, Xiao; Liu, Hanchen; Zhang, Zezhong; Yang, Wenlan; Wu, Chunyan

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PM2.5 exposure mRNA m(5)C Pulmonary fibrosis Inflammation Immune response

5-methylcytosine promotes mRNA export-NSUN2 as the methyltransferase and ALYREF as an m(5)C reader 期刊论文 OAI收割
CELL RESEARCH, 2017, 卷号: 27, 期号: 5, 页码: 606-625
作者: Ma, Hai-Li; Zhu, Qin; Sun, Hui-Ying; Xiao, Wen; Bhattarai, Devi Prasad

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m(5)c Mrna Export Alyref Nsun2

TRPC4/C5抑制剂M084抗抑郁作用及机制研究 学位论文 OAI收割
博士, 昆明: 中国科学院大学, 2015
作者: 杨丽萍

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抗抑郁 TRPC4/C5 BDNF 情绪相关疾病 M084

Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文 OAI收割
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者: Zeng, Guang-Zhi; Fan, Jun-Ting; Xu, Jun-Ju; Li, Yan; Tan, Ning-Hua

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2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA) one of the major components isolated from the traditional Chinese medicine Rubia yunnanensis exhibited inhibitory activity on the proliferation of several human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle arrest in human cervical carcinoma HeLa cells. Further MTA was found to induce apoptosis of HeLa cells through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and release of cytochrome c into the cytosol which caused the cleavage of caspase and poly(ADP-ribose) polymerase and finally triggered the apoptosis. Furthermore the p53/p21/Cdc2-cyclin B1 signaling was found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of R. yunnanensis a folk anti-cancer herb used in Yunnan China.

一种单一聚合度壳寡糖制备方法 专利 OAI收割
专利类型: 发明, 专利号: CN201210146042.7, 申请日期: 2012-09-05, 公开日期: 2012-09-05
作者: 邢荣娥; 李鹏程; 于华华; 秦玉坤

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一种单一聚合度壳寡糖的制备方法其特征在于：将全脱乙酰化壳寡糖溶解过滤后用离子交换色谱柱CM?Sephadex?C?25以0?3M浓度的NaCl溶液在2?5mL/min?1的流速下进行分离纯化收集240?360min 360?460min 460?560min 560?640min 640?720min 720?780min 780?840min的洗脱液将所得洗脱液分别经活性碳萃取脱盐后浓缩即得到单一聚合度全脱乙酰化壳寡糖。

氮杂环类化合物及其制备和应用 专利 OAI收割
专利类型: 发明, 专利号: CN201110341803.X, 申请日期: 2012-06-27, 公开日期: 2012-06-27
李伟华; 白雪; 曹锟; 孙丛涛; 侯保荣

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一种氮杂环类化合物 b：5?m?甲苯?[1 c：5?p?甲苯?[1 其特征在于：所述氮杂环类化合物为a：5?o?甲苯?[1 3 3 3 4]噻二唑?2?巯基 4]噻二唑?2?巯基 4]噻二唑?2?巯基结构式为：FSA00000604167900011.tif

一种缓释型苯甲酸根阴离子插层水滑石碳钢防腐蚀材料及其制备和应用 专利 OAI收割
专利类型: 发明, 专利号: CN201110041730.2, 申请日期: 2011-08-03, 公开日期: 2011-08-03
作者: 王毅

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一种缓释型苯甲酸根阴离子插层水滑石碳钢防腐蚀材料 M2+/M3+的摩尔比为1.6～4.5 0.2≤x≤0.4。其特征在于：所述防腐蚀材料化学组成通式为[M2+1?xM3+x(OH)2]x+(C6H5COO?)x·nH2O M2+代表二价金属离子Mg2+ Zn2+ Ni2+ Fe2+ Mn2+中的任何一种 M3+代表三价金属离子Al3+ Cr3+ Fe3+ V3+ Co3+ Ga3+ Ti3+中的任何一种

Characteristics of ZnMgO-based metal-semiconductor-metal photodetectors (EI CONFERENCE) 会议论文 OAI收割
International Symposium on Photoelectronic Detection and Imaging, ISPDI 2007: Photoelectronic Imaging and Detection, September 9, 2007 - September 12, 2007, Beijing, China
作者: Zhang J.; Li B.; Li B.; Li B.; Zhao Y.

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In recent years ZnMgO semiconductor alloys with a direct bandgap tunable between 3.37 eV and 7.8 eV become one of the most suitable materials for the fabrication of ultraviolet detectors. In this paper we have fabricated metal-semiconductor-metal photodetectors on 1-m thick Zn 0.8Mg0.2O films. The interdigital metal electrodes are 500 m long and 5 m wide with an interelectrode spacing 2 m 5 m and 10 m respectively. Zn0.8Mg0.2O films were grown on quartz by ratio frequency magnetron sputtering at 500C. Dark current spectral responsivity and pulse response were carried out for the devices with different finger pitches. All the photodetectors showed the peak responsivity at 330 nm and the ultraviolet-visible rejection ratio (R330 nm/R400 nm) is more than four orders of magnitude at 3 V bias. For the device with 2 m finger pitch the detectivity was calculated as 4.21011 cm Hz 1/2/W at 330 nm. Furthermore the transient response measurement for all devices revealed similar rise time of 10 ns. The 90%-10% fall times are 130 ns 170 ns and 230 ns for the devices with different finger pitches of 2 m 5 m and 10 m respectively..

The synthesis and field emission property of carbon nanotubes on carbon fibers substrate (EI CONFERENCE) 会议论文 OAI收割
Technical Digest of the 20th International Vacuum Nanoelectronics Conference, IVNC 07, July 8, 2008 - July 12, 2008, Chicago, IL, United states
Leyong Z.; Weibiao W.; Jingqiu L.; Yuxue X.; Da L.; Song C.; Haifeng Z.

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Using ferrocene as catalyst precursor C2H2 as carbon source carbon nanotubes (CNTs) with uniform density were synthesized on carbon fibers substrate by floating catalyst method. The morphology and microstructure were characterized by field emission scanning electron microscope (FESEM) and high-resolution transmission electron microscopy (HRTEM). The observation showed that the length of CNTs is about 2 m the average space between adjacent CNTs is about 300 nm and the diameter of CNT is about 45 nm. The less dense "short and stubby" aligned CNTs films should have good electron field emission characteristics. The results of field emission showed that the emission current of CNTs/carbon fibers was 5 A at the field of 2.5 V/m and the emission current can be 280 A with a field of 7 V/m (the specimen area is 0.25 cm2 and the distance between cathode and anode is 200 m). The calculation based on the F-N plot indicated that the field enhancement factor of CNTs tip is 499122. Using the conductivity and chemical stability of carbon fibers and the uniform and sparse density distribution of CNTs on carbon fibers substrate the tip predominance of carbon nanotubes can be exerted and simultaneously the effect of screening effects between adjacent carbon nanotubes on the field emission performance can also be effectively decreased. The CNTs synthesized on carbon fibers substrate has many predominances for the fabrication of cold cathode devices. For example using the removability of carbon fibers the cathode of CNTs/carbon fibers can be arbitrarily moved enlaced or combined to form different patterns and the cathode of CNTs/carbon fibers can be also fabricated in large size. Therefore CNTs/carbon fibers may have potential application in field emission displays.