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	Circular RNA cMras Suppresses the Progression of Lung Adenocarcinoma Through ABHD5/ATGL Axis Using NF-kappa B Signaling Pathway 期刊论文 OAI收割 CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS, 2020 作者: Zhou, Qinfei; Sun, Yan \| 收藏 \| 浏览/下载：33/0 \| 提交时间：2020/12/28 ABHD5 ATGL circ_cMras LAC NF-κ B signaling pathway p53
	Effects of C-12(6+) heavy ion beam irradiation on the p53 signaling pathway in HepG2 liver cancer cells 期刊论文 OAI收割 ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2017, 卷号: 49, 页码: 989-998 作者: Liu, Kai; Zhao, Xinke; Gu, Jing; Wu, Jianjun; Zhang, Hong \| 收藏 \| 浏览/下载：34/0 \| 提交时间：2018/05/31 C-12(6+) heavy ion beam HepG2 p53 signaling pathway apoptosis
	Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文 OAI收割 PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299 作者: Zeng, Guang-Zhi; Fan, Jun-Ting; Xu, Jun-Ju; Li, Yan; Tan, Ning-Hua 收藏 \| 浏览/下载：47/0 \| 提交时间：2015/05/14 2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA) one of the major components isolated from the traditional Chinese medicine Rubia yunnanensis exhibited inhibitory activity on the proliferation of several human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle arrest in human cervical carcinoma HeLa cells. Further MTA was found to induce apoptosis of HeLa cells through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and release of cytochrome c into the cytosol which caused the cleavage of caspase and poly(ADP-ribose) polymerase and finally triggered the apoptosis. Furthermore the p53/p21/Cdc2-cyclin B1 signaling was found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of R. yunnanensis a folk anti-cancer herb used in Yunnan China.
	Genistein Enhances the Radiosensitivity of Breast Cancer Cells via G(2)/M Cell Cycle Arrest and Apoptosis 期刊论文 OAI收割 MOLECULES, 2013, 卷号: 18, 页码: 13200-13217 作者: Li, P; Zhao, T; Gong, L; Li, Q; Li, Q (reprint author), Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Gansu, Peoples R China. \| 收藏 \| 浏览/下载：24/0 \| 提交时间：2015/11/20 Estrogen-receptor Dna-damage In-vitro Antiproliferative Properties Signaling Pathway Prostate-cancer P53 Family Tumorigenesis Supplements Mda-mb-231