中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [309]
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Decoding the pharmacokinetics of intravenous lentinan: A multiscale journey from the blood to hepatic Kupffer cells' lysosomes
期刊论文
OAI收割
CARBOHYDRATE POLYMERS, 2026, 卷号: 374, 页码: 17
作者:
Mu, Xu
;
Wang, Jinglin
;
Wan, Shuai
;
Wang, Jingyi
;
Huang, Lei
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2026/01/28
Intravenous lentinan
Multiscale pharmacokinetics
Radio-HPGPC
CR3
Lysosomal acidification
Smart microneedles empowering programmable and sustained drug delivery
期刊论文
OAI收割
COORDINATION CHEMISTRY REVIEWS, 2026, 卷号: 548, 页码: 28
作者:
Zeng, Weishu
;
Ding, Qihang
;
Zhang, Zhe
;
Zhao, Jiaqi
;
Ding, Xu
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2025/12/04
Microneedles
Transdermal Drug Delivery
Controlled Release
Pharmacokinetics
Stimuli-Responsive Systems
Wound Management
Pharmacokinetics, mass balance, and metabolism of the novel potassium-competitive acid blocker JP-1366 in healthy Chinese adults following a single oral dose of [
14
C]JP-1366
期刊论文
OAI收割
FRONTIERS IN PHARMACOLOGY, 2025, 卷号: 16, 页码: 11
作者:
Liu, Xuemei
;
Deng, Decheng
;
Meng, Jian
;
Hu, Haitang
;
Zhuang, Quankun
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2026/01/28
JP-1366
P-CABs
mass balance study
radioactivity
drug metabolism
pharmacokinetics
Qualitative and quantitative determination of SIPI-2011 and its two major metabolites in human plasma
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2025, 卷号: 264, 页码: 11
作者:
Fang, Jie
;
Jing, Jiao
;
Li, Guangyao
;
Wang, Yongbin
;
Zhao, Binjiang
  |  
收藏
  |  
浏览/下载:81/0
  |  
提交时间:2025/08/20
SIPI-2011
UPLC-UV/Q-TOF
LC-MS/MS
Metabolic Profiling
Pharmacokinetics
Pharmacokinetic Drug Interactions of TPN171 When Coadministration With Rifampicin or Itraconazole
期刊论文
OAI收割
CLINICAL THERAPEUTICS, 2025, 卷号: 47, 期号: 9, 页码: 706-712
作者:
Liang, Liyu
;
Qin, Haiping
;
Liu, Gangyi
;
Qian, Hongjie
;
Xin, Liang
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2025/12/04
Drug interactions
Pharmacokinetics
Safety
TPN171
Pharmacokinetics, mass balance, and metabolism of [
14
C]SAF-189s, a potent anaplastic lymphoma kinase/c-ROS proto-oncogene 1 inhibitor in humans: Metabolism potentially affected by interaction of cytochrome P450 enzymes and intestinal microbiota
期刊论文
OAI收割
DRUG METABOLISM AND DISPOSITION, 2025, 卷号: 53, 期号: 9, 页码: 14
作者:
Yang, Ming
;
Diao, Lei
;
Yan, Shu
;
Tan, Yan
;
Liu, Donghui
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2025/12/04
[C-14]SAF-189s
SAF-189s metabolism and pharmacokinetics
Non-small cell lung cancer
ALK/ROS1 inhibitor
Intestinal flora
P450 enzymes
Effect of Hepatic Impairment on the Pharmacokinetics of Baicalin in Rats: Critical Roles of Gut Microbiota and Hepatic Transporters
期刊论文
OAI收割
PHARMACEUTICS, 2025, 卷号: 17, 期号: 7, 页码: 15
作者:
Li, Ping
;
Tian, Yihua
;
Wang, Hong
;
Ji, Yuting
;
Zeng, Huiying
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2025/12/04
baicalin
hepatic impairment
pharmacokinetics
gut microbiota
hepatic transporters
enterohepatic circulation
Pharmacokinetics and Safety of TPN171 (a PDE5 Inhibitor) in Patients With Mild or Moderate Hepatic Impairment Versus Participants With Normal Hepatic Function: A Phase I Study
期刊论文
OAI收割
CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2025, 页码: 7
作者:
Zhou, Jing
;
Zhang, Hong
;
Ding, Yanhua
;
Wang, Zhen
;
Wang, Yu
  |  
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2025/06/23
hepatic impairment
pharmacokinetics
phosphodiesterase-5 inhibitor
TPN171
A Phase I Study to Evaluate the Pharmacokinetics and Safety of TPN171 (a PDE5 Inhibitor) in Adults with Renal Impairment
期刊论文
OAI收割
CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2025, 页码: 8
作者:
Fu, Ping
;
Song, Yi
;
Hu, Chao
;
Yong, Xiaolan
;
Yu, Yang
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2025/06/23
pharmacokinetics
phosphodiesterase 5 inhibitor
renal impairment
safety
TPN171
Hemodynamic and Pharmacokinetic Interactions of TPN171 with Alcohol in Healthy Male Subjects
期刊论文
OAI收割
CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2025, 卷号: 18, 期号: 2, 页码: 8
作者:
Cheng, Jie
;
Qian, Hongjie
;
Wang, Yu
;
Liang, Liyu
;
Xu, Wenjing
  |  
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2025/04/01
alcohol
healthy subjects
hemodynamics
PDE5 inhibitor
pharmacokinetics
TPN171