中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [1]
大连化学物理研究所 [1]
水生生物研究所 [1]
中国科学院大学 [1]
采集方式
OAI收割 [3]
iSwitch采集 [1]
内容类型
期刊论文 [4]
发表日期
2022 [1]
2015 [1]
2010 [2]
学科主题
Pharmacolo... [1]
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Changes in Disposition of Ezetimibe and Its Active Metabolites Induced by Impaired Hepatic Function: The Influence of Enzyme and Transporter Activities
期刊论文
OAI收割
PHARMACEUTICS, 2022, 卷号: 14, 期号: 12, 页码: 22
作者:
Xie, Ningjie
;
Wang, Hong
;
Qin, Hua
;
Guo, Zitao
;
Xue, Hao
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2023/04/10
hepatic impairment
ezetimibe
active metabolites
phase II enzymes
transporters
first-pass metabolism
inhibitory bile acids
In Vitro Evaluation of the Effect of 7-Methyl Substitution on Glucuronidation of Daphnetin: Metabolic Stability, Isoform Selectivity, and Bioactivity Analysis
期刊论文
OAI收割
journal of pharmaceutical sciences, 2015, 卷号: 104, 期号: 10, 页码: 3557-3564
作者:
Liang, Si-Cheng
;
Ge, Guang-Bo
;
Xia, Yang-Liu
;
Zhang, Jiang-Wei
;
Qi, Xiao-Yi
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2015/11/17
daphnetin
glucuronidation
methyl substitution
structural modification
metabolic stability
phase II enzymes
glucuronosyltransferases
human liver microsomes
enzyme kinetics
metabolic clearance
Hydroxytyrosol protects against oxidative damage by simultaneous activation of mitochondrial biogenesis and phase ii detoxifying enzyme systems in retinal pigment epithelial cells
期刊论文
iSwitch采集
Journal of nutritional biochemistry, 2010, 卷号: 21, 期号: 11, 页码: 1089-1098
作者:
Zhu, Lu
;
Liu, Zhongbo
;
Feng, Zhihui
;
Hao, Jiejie
;
Shen, Weili
收藏
  |  
浏览/下载:57/0
  |  
提交时间:2019/05/10
Hydroxytyrosol
Rpe cells
Acrolein
Amd
Mitochondrial biogenesis
Phase ii enzymes
Sulforaphane protects Microcystin-LR-induced toxicity through activation of the Nrf2-mediated defensive response
期刊论文
OAI收割
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2010, 卷号: 247, 期号: 2, 页码: 129-137
作者:
Gan, Nanqin
;
Mi, Lixin
;
Sun, Xiaoyun
;
Dai, Guofei
;
Chung, Fung-Lung
收藏
  |  
浏览/下载:87/21
  |  
提交时间:2010/12/23
Microcystin-LR (MC-LR)
Sulforaphane (SFN)
NF-E2-related factor 2 (Nrf2)
Phase II enzymes
Glutathione (GSH)
Chemoprevention